[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100598351":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":10,"centralContacts":19,"locations":25,"responsibleParty":39,"collaborators":10,"id":43,"slug":10,"hasResults":44,"nctId":45,"briefTitle":46,"officialTitle":47,"acronym":10,"eligibilityCriteria":48,"healthyVolunteers":44,"sex":49,"minAge":50,"maxAge":10,"enrollmentInfo":51,"targetDuration":10,"studyType":54,"phases":10,"briefSummary":55,"conditions":56,"keywords":64,"overallStatus":28,"whyStopped":10,"lastUpdateSubmitDate":70,"lastUpdatePostDateStruct":71,"startDateStruct":74,"completionDateStruct":76,"leadSponsor":78,"locationsCount":79},{"fullName":5,"class":6},"Beijing Tsinghua Chang Gung Hospital","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"patients undergoing major liver surgury",null,"Population: 2,497 adult patients (≥18 years) who underwent major liver surgery (≥2 segments resection or transplantation) at Beijing Tsinghua Changgung Hospital, including retrospective (2019.06-2024.05) and prospective (from 2025.12) cohorts.\n\nInclusion Criteria: Aged ≥18, scheduled for major liver surgery, with informed consent.\n\nExclusion Criteria: Refusal to participate, comorbidities affecting ALI assessment, incomplete data, failed follow-up, or concurrent trials.\n\nInterventions: None. Observational study; clinical management follows standard protocols without study-related interventions. Data collected from routine records and monitoring.",[13],"Other: None-placebo",[15],{"type":6,"name":16,"description":17,"armGroupLabels":18,"otherNames":10},"None-placebo","This observational cohort study is non-interventional. Perioperative treatment plans are made based on model - suggested results and anesthesiologists' thought processes, without adding new medicines for patients.",[9],[20],{"name":21,"role":22,"phone":23,"phoneExt":10,"email":24},"Gao Zhifeng, MD","CONTACT","+8615801249466","btchgzf@hotmail.com",[26],{"facility":27,"status":28,"city":29,"state":30,"zip":31,"country":32,"cosmosGeoPoint":33,"geoPoint":38,"contacts":10},"Beijing Tsinghua Changgung Hospital, School of Clinical Medicine, Tsinghua Medicine，Tsinghua University","RECRUITING","Beijing","Beijing Municipality","102218","China",{"type":34,"coordinates":35},"Point",[36,37],116.39723,39.9075,{"lat":37,"lon":36},{"type":40,"investigatorFullName":41,"investigatorTitle":42,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"PRINCIPAL_INVESTIGATOR","Zhifeng Gao","Chief physician","100598351",false,"NCT07070362","Digital Early Warning System for Acute Lung Injury in Liver Surgery","The Construction of a Digital Intelligence Early Warning System for the Whole Process of Acute Lung Injury in Liver Surgery Based on Cardiopulmonary Interaction Characteristics","Inclusion Criteria:\n\n* Age ≥ 18 years\n* Undergoing major liver surgery (including two-segment or more hepatectomy, liver transplantation, etc.)\n* Voluntary participation with signed informed consent","ALL","18 Years",{"count":52,"type":53},4000,"ESTIMATED","OBSERVATIONAL","This study focuses on developing an explainable machine learning model based on cardiopulmonary interaction characteristics to achieve early prediction of acute lung injury (ALI) in patients undergoing major liver surgery. The research will establish a digital early-warning system for ALI to provide support for clinical diagnosis and treatment decisions, thereby reducing the incidence and fatality rate of ALI.",[57,58,59,60,61,62,63],"Acute Lung Injury(ALI)","Liver Cirrhosis","ARDS, Human","MASLD","MASLD\u002FMASH (Metabolic Dysfunction-Associated Steatotic Liver Disease \u002F Metabolic Dysfunction-Associated Steatohepatitis)","NAFLD (Nonalcoholic Fatty Liver Disease)","Liver Cancer, Adult",[65,66,67,68,69],"Digital Intelligence","Acute Lung Injury","PPCs","Liver Surgery","Cardiopulmonary Interaction;","2025-07-08",{"date":72,"type":73},"2025-07-17","ACTUAL",{"date":75,"type":73},"2024-11-01",{"date":77,"type":53},"2027-11-30",{"name":5,"class":6},1]