[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100573090":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":31,"centralContacts":32,"locations":42,"responsibleParty":77,"collaborators":31,"id":81,"slug":31,"hasResults":82,"nctId":83,"briefTitle":84,"officialTitle":85,"acronym":86,"eligibilityCriteria":87,"healthyVolunteers":82,"sex":88,"minAge":89,"maxAge":90,"enrollmentInfo":91,"targetDuration":31,"studyType":94,"phases":95,"briefSummary":97,"conditions":98,"keywords":104,"overallStatus":111,"whyStopped":31,"lastUpdateSubmitDate":112,"lastUpdatePostDateStruct":113,"startDateStruct":116,"completionDateStruct":118,"leadSponsor":120,"locationsCount":121},{"fullName":5,"class":6},"Chinese University of Hong Kong","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Direct Warming method","EXPERIMENTAL","The blastocyst designated for thawing will be placed in a pre-warmed, direct warming medium for one minute. Afterward, the embryo is transferred into an embryo culture medium within a time-lapse system, where it remains until the patient is ready for the embryo transfer procedure. This direct warming method significantly reduces the total procedure time to approximately 3 minutes, making it about ten times faster than the conventional multi-step thawing method.",[13],"Other: Direct Warming Method",{"label":15,"type":16,"description":17,"interventionNames":18},"Conventional multi-step thawing method","PLACEBO_COMPARATOR","In the conventional multi-step thawing method, vitrified blastocysts are sequentially thawed using a series of pre-warmed thawing, dilution, and washing solutions. The blastocyst is first placed in a thawing solution for 1-3 minutes, followed by immersion in a dilution solution for 4-6 minutes to reduce cryoprotectant concentration. Finally, the blastocyst is transferred to a washing solution for 5-10 minutes for rehydration. The entire process takes approximately 30 minutes, after which the embryo is placed into an embryo culture medium in a time-lapse system until it is ready for embryo transfer.",[19],"Other: Conventional Multi-step Thawing Method",[21,27],{"type":6,"name":22,"description":23,"armGroupLabels":24,"otherNames":25},"Direct Warming Method","This intervention involves thawing vitrified blastocysts using a simplified, one-step direct warming method. The blastocyst is placed in a pre-warmed embryo culture medium for approximately one minute, then transferred directly into the embryo culture medium within a time-lapse system until ready for uterine transfer. The total thawing process takes approximately three minutes, reducing the duration and complexity of the procedure compared to conventional methods.",[9],[26],"One-step thawing",{"type":6,"name":28,"description":29,"armGroupLabels":30,"otherNames":31},"Conventional Multi-step Thawing Method","This intervention involves thawing vitrified blastocysts using a standard, multi-step process. The procedure includes sequential exposure of the blastocyst to different thawing solutions containing varying concentrations of cryoprotectants, followed by its transfer into an embryo culture medium in a time-lapse system. The overall process takes approximately 10-30 minutes.",[15],null,[33,38],{"name":34,"role":35,"phone":36,"phoneExt":31,"email":37},"Yiu Leung D Chan, DPhil","CONTACT","(852) 3505 3199","drdcyl16@cuhk.edu.hk",{"name":39,"role":35,"phone":40,"phoneExt":31,"email":41},"Waner Wu, MPhil","(852) 3505 1764","wanerwu@link.cuhk.edu.hk",[43,50,63],{"facility":44,"status":31,"city":45,"state":46,"zip":31,"country":47,"cosmosGeoPoint":31,"geoPoint":31,"contacts":48},"The Chinese University of Hong Kong","Shatin, New Territories","Hong Kong SAR","Hong Kong",[49],{"name":31,"role":35,"phone":40,"phoneExt":31,"email":31},{"facility":51,"status":31,"city":52,"state":46,"zip":31,"country":47,"cosmosGeoPoint":53,"geoPoint":58,"contacts":59},"The CUHK Medical centre","Shatin,NT",{"type":54,"coordinates":55},"Point",[56,57],114.18333,22.38333,{"lat":57,"lon":56},[60],{"name":61,"role":35,"phone":62,"phoneExt":31,"email":37},"Yiu Leung, David Chan","+852 3946 6888",{"facility":64,"status":31,"city":65,"state":65,"zip":31,"country":66,"cosmosGeoPoint":67,"geoPoint":71,"contacts":72},"The Homerton Hospital","London","United Kingdom",{"type":54,"coordinates":68},[69,70],-0.12574,51.50853,{"lat":70,"lon":69},[73],{"name":74,"role":35,"phone":75,"phoneExt":31,"email":76},"Priya Bhide","020 8510 5555","p.bhide@qmul.ac.uk",{"type":78,"investigatorFullName":79,"investigatorTitle":80,"investigatorAffiliation":5,"oldNameTitle":31,"oldOrganization":31},"PRINCIPAL_INVESTIGATOR","Yiu Leung David Chan","Assistant Professor","100573090",false,"NCT06741748","Direct Warming Frozen Embryo Transfer Outcomes in Assisted Reproductive Technology","A Pragmatic, Multi-centre, Double-blinded, Two-arm Randomized Controlled Trial on a Direct Warming Frozen Embryo Transfer in Assisted Reproductive Technologies Treatment Outcome","DW-FET-RCT","Inclusion Criteria:\n\n* Plan to undergo single embryo transfer (SET) during the FET cycle.\n* Age between 18 and 45 years.\n* Patients with at least one high-quality blastocyst available for transfer.\n* Patients who have provided informed consent to participate in the study.\n\nExclusion Criteria:\n\n* Patients with repeated implantation failure (RIF) or recurrent miscarriage (RM).\n* Patients with known uterine anomalies or significant uterine pathology (e.g., fibroids, polyps).\n* Patients who are unwilling or unable to provide informed consent.","FEMALE","18 Years","45 Years",{"count":92,"type":93},578,"ESTIMATED","INTERVENTIONAL",[96],"NA","The goal of this clinical trial is to evaluate whether the direct warming method for frozen embryo transfers (FET) can improve live birth and pregnancy outcomes in women aged 18-45 undergoing IVF treatments. The main questions it aims to answer are:\n\n* Does the direct warming method achieve a similar or higher clinical success rate for FET compared to the conventional multi-step method?\n* Is the direct warming method more cost-effective than the conventional method?\n\nResearchers will compare the direct warming method to the conventional multi-step method to see if the former leads to better pregnancy outcomes and reduced procedural time.\n\nParticipants will:\n\n* Undergo either the one-step or conventional embryo thawing procedure.\n* Complete standard clinical follow-ups for pregnancy, including ultrasound scans and pregnancy tests.",[99,100,101,102,103],"Frozen Embryo Transfer (FET)","Assisted Reproductive Techniques","In Vitro Fertilization (IVF)","Cryopreservation of Embryos","Pregnancy Outcome After in Vitro Fertilization (IVF)",[22,105,106,107,108,109,110],"Frozen Embryo Transfer","Assisted Reproductive Technologies","Cryopreservation","Cost-effectiveness in ART","Embryo Warming","In Vitro Fertilization","NOT_YET_RECRUITING","2025-03-06",{"date":114,"type":115},"2025-03-11","ACTUAL",{"date":117,"type":93},"2025-09-01",{"date":119,"type":93},"2027-10-31",{"name":5,"class":6},3]