[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100556450":3},{"organization":4,"outcomesModule":7,"designInfo":18,"detailedDescription":21,"studyPopulation":22,"armGroups":17,"interventions":17,"overallOfficials":17,"centralContacts":23,"locations":32,"responsibleParty":388,"collaborators":17,"id":391,"slug":17,"hasResults":392,"nctId":393,"briefTitle":394,"officialTitle":394,"acronym":395,"eligibilityCriteria":396,"healthyVolunteers":392,"sex":397,"minAge":398,"maxAge":399,"enrollmentInfo":400,"targetDuration":17,"studyType":403,"phases":17,"briefSummary":404,"conditions":405,"keywords":17,"overallStatus":35,"whyStopped":17,"lastUpdateSubmitDate":407,"lastUpdatePostDateStruct":408,"startDateStruct":411,"completionDateStruct":413,"leadSponsor":415,"locationsCount":416},{"fullName":5,"class":6},"George Washington University","OTHER",{"primaryOutcomes":8,"secondaryOutcomes":13,"otherOutcomes":17},[9],{"measure":10,"description":11,"timeFrame":12},"Type 2 diabetes","Development of type 2 diabetes, as defined by a hemoglobin A1c (HbA1c) ≥6.5% at an annual or mid-year visit followed by a confirmatory HbA1c ≥6.5% collected within 2 weeks of the first value.","Through study completion, an average of 2.5 years",[14],{"measure":15,"description":16,"timeFrame":12},"Glycemia, β-cell function, insulin sensitivity, and free fatty acid flux","Intermediary changes in glycemia, β-cell function, insulin sensitivity, and free fatty acid flux along the spectrum of normal glycemia to prediabetes to type 2 diabetes.",null,{"allocation":17,"interventionModel":17,"interventionModelDescription":17,"primaryPurpose":17,"observationalModel":19,"timePerspective":20,"maskingInfo":17},"COHORT","PROSPECTIVE","The DISCOVERY study will extensively phenotype a large cohort of youth at-risk for type 2 diabetes, as they transition through puberty, and characterize the course of dysfunction in pathophysiological indicators that lead to type 2 diabetes. The knowledge gained from this study of the pathophysiology and epidemiology of youth-onset type 2 diabetes with deep biochemical, clinical, and psychosocial phenotyping will critically inform the design and testing of future treatment and prevention approaches.","3,600 youth, aged 8-15 years at enrollment, of all genders and race\u002Fethnic groups from 15 clinical centers in the United States will be included. Youth will be overweight or obese (BMI ≥85th percentile for age) and have evidence of dysglycemia with an HbA1c range from 5.5-6.4% at screening.",[24,29],{"name":25,"role":26,"phone":27,"phoneExt":17,"email":28},"Barbara Braffett, PhD","CONTACT","3018819260","braffett@bsc.gwu.edu",{"name":30,"role":26,"phone":27,"phoneExt":17,"email":31},"Brian Burke, MS","bburke@bsc.gwu.edu",[33,57,74,87,104,123,140,156,177,196,215,230,243,259,276,292,312,330,347,367],{"facility":34,"status":35,"city":36,"state":37,"zip":38,"country":39,"countryCode":40,"cosmosGeoPoint":41,"geoPoint":46,"contacts":47},"University of Alabama at Birmingham","RECRUITING","Birmingham","Alabama","35294","United States","US",{"type":42,"coordinates":43},"Point",[44,45],-86.80249,33.52066,{"lat":45,"lon":44},[48,52,55],{"name":49,"role":26,"phone":50,"phoneExt":17,"email":51},"Laura Lee Goree","205-934-4386","discovery@uab.edu",{"name":53,"role":54,"phone":17,"phoneExt":17,"email":17},"Barbara Gower, PhD","PRINCIPAL_INVESTIGATOR",{"name":56,"role":54,"phone":17,"phoneExt":17,"email":17},"Ambika Ashraf, MD",{"facility":58,"status":35,"city":59,"state":60,"zip":61,"country":39,"countryCode":40,"cosmosGeoPoint":62,"geoPoint":66,"contacts":67},"Arizona State University","Phoenix","Arizona","85004",{"type":42,"coordinates":63},[64,65],-112.07404,33.44838,{"lat":65,"lon":64},[68,72],{"name":69,"role":26,"phone":70,"phoneExt":17,"email":71},"Irene Marquez","602-496-0147","imarqu13@asu.edu",{"name":73,"role":54,"phone":17,"phoneExt":17,"email":17},"Gabriel Shaibi, PhD",{"facility":75,"status":35,"city":59,"state":60,"zip":76,"country":39,"countryCode":40,"cosmosGeoPoint":77,"geoPoint":79,"contacts":80},"Phoenix Children's","85006",{"type":42,"coordinates":78},[64,65],{"lat":65,"lon":64},[81,85],{"name":82,"role":26,"phone":83,"phoneExt":17,"email":84},"Lynette B Davis","602-933-6359","Ldavis8@phoenixchildrens.com",{"name":86,"role":54,"phone":17,"phoneExt":17,"email":17},"Melissa Chambers, DO",{"facility":88,"status":35,"city":89,"state":90,"zip":91,"country":39,"countryCode":40,"cosmosGeoPoint":92,"geoPoint":96,"contacts":97},"Children's Hospital Los Angeles","Los Angeles","California","90027",{"type":42,"coordinates":93},[94,95],-118.24368,34.05223,{"lat":95,"lon":94},[98,102],{"name":99,"role":26,"phone":100,"phoneExt":17,"email":101},"Leticia Eufracio","323-497-5088","leufracio@chla.usc.edu",{"name":103,"role":54,"phone":17,"phoneExt":17,"email":17},"Michael Goran, PhD",{"facility":105,"status":35,"city":106,"state":107,"zip":108,"country":39,"countryCode":40,"cosmosGeoPoint":109,"geoPoint":113,"contacts":114},"Children's Hospital Colorado","Aurora","Colorado","80045",{"type":42,"coordinates":110},[111,112],-104.83192,39.72943,{"lat":112,"lon":111},[115,119,121],{"name":116,"role":26,"phone":117,"phoneExt":17,"email":118},"Kelly Wiitala","720-777-2855","DISCOVERY@childrenscolorado.org",{"name":120,"role":54,"phone":17,"phoneExt":17,"email":17},"Kristen Nadeau, MD",{"name":122,"role":54,"phone":17,"phoneExt":17,"email":17},"Megan Kelsey, MD",{"facility":124,"status":35,"city":125,"state":126,"zip":127,"country":39,"countryCode":40,"cosmosGeoPoint":128,"geoPoint":132,"contacts":133},"Johns Hopkins All Children's Hospital","St. Petersburg","Florida","33701",{"type":42,"coordinates":129},[130,131],-82.67927,27.77086,{"lat":131,"lon":130},[134,138],{"name":135,"role":26,"phone":136,"phoneExt":17,"email":137},"Antonika Ford","727-898-4895","aford38@jh.edu",{"name":139,"role":54,"phone":17,"phoneExt":17,"email":17},"Sheela N Magge, MD, MSCE",{"facility":141,"status":35,"city":142,"state":143,"zip":144,"country":39,"countryCode":40,"cosmosGeoPoint":145,"geoPoint":149,"contacts":150},"Johns Hopkins University School of Medicine","Baltimore","Maryland","21287",{"type":42,"coordinates":146},[147,148],-76.61219,39.29038,{"lat":148,"lon":147},[151,155],{"name":152,"role":26,"phone":153,"phoneExt":17,"email":154},"Benjamin Potts","443-287-8997","bpotts2@jh.edu",{"name":139,"role":54,"phone":17,"phoneExt":17,"email":17},{"facility":157,"status":35,"city":158,"state":159,"zip":160,"country":39,"countryCode":40,"cosmosGeoPoint":161,"geoPoint":165,"contacts":166},"Boston Children's\u002FJoslin Diabetes Center\u002FMassachusetts General Hospital","Boston","Massachusetts","02215",{"type":42,"coordinates":162},[163,164],-71.05977,42.35843,{"lat":164,"lon":163},[167,171,173,175],{"name":168,"role":26,"phone":169,"phoneExt":17,"email":170},"Jackson Tu","617-309-4193","DISCOVERYTeam@joslin.harvard.edu",{"name":172,"role":54,"phone":17,"phoneExt":17,"email":17},"Elvira Isganaitis, MD, MPH",{"name":174,"role":54,"phone":17,"phoneExt":17,"email":17},"Amy Fleischman, MD",{"name":176,"role":54,"phone":17,"phoneExt":17,"email":17},"Takara Stanley, MD, PhD",{"facility":178,"status":35,"city":179,"state":180,"zip":181,"country":39,"countryCode":40,"cosmosGeoPoint":182,"geoPoint":186,"contacts":187},"Colorado Navajo Nation","Shiprock","New Mexico","87420",{"type":42,"coordinates":183},[184,185],-108.68703,36.78555,{"lat":185,"lon":184},[188,192,194],{"name":189,"role":26,"phone":190,"phoneExt":17,"email":191},"Melanie Aspaas","720-957-5074","melanie.aspaas@cuanschutz.edu",{"name":193,"role":54,"phone":17,"phoneExt":17,"email":17},"Dana Dabelea, MD, PhD",{"name":195,"role":54,"phone":17,"phoneExt":17,"email":17},"Wei Perng, PhD, MPH",{"facility":197,"status":35,"city":198,"state":199,"zip":200,"country":39,"countryCode":40,"cosmosGeoPoint":201,"geoPoint":205,"contacts":206},"NYU Langone Health- Brooklyn","Brooklyn","New York","11220",{"type":42,"coordinates":202},[203,204],-73.94958,40.6501,{"lat":204,"lon":203},[207,211,213],{"name":208,"role":26,"phone":209,"phoneExt":17,"email":210},"Celia Engelson","929-731-2272","DiscoveryStudyBrooklyn@nyulangone.org",{"name":212,"role":54,"phone":17,"phoneExt":17,"email":17},"Mary Pat Gallagher, MD",{"name":214,"role":54,"phone":17,"phoneExt":17,"email":17},"Alan Jacobson, MD",{"facility":216,"status":35,"city":217,"state":199,"zip":218,"country":39,"countryCode":40,"cosmosGeoPoint":219,"geoPoint":223,"contacts":224},"NYU Langone Health- Long Island","Garden City","11530",{"type":42,"coordinates":220},[221,222],-73.6343,40.72677,{"lat":222,"lon":221},[225,229],{"name":226,"role":26,"phone":227,"phoneExt":17,"email":228},"Marilyn Richardson","516-969-6120","DiscoveryStudyLI@nyulangone.org",{"name":214,"role":54,"phone":17,"phoneExt":17,"email":17},{"facility":231,"status":35,"city":199,"state":199,"zip":232,"country":39,"countryCode":40,"cosmosGeoPoint":233,"geoPoint":237,"contacts":238},"NYU Langone Health- Manhattan","10016",{"type":42,"coordinates":234},[235,236],-74.00597,40.71427,{"lat":236,"lon":235},[239,242],{"name":240,"role":26,"phone":209,"phoneExt":17,"email":241},"Laura March","DiscoveryStudyManhattan@nyulangone.org",{"name":212,"role":54,"phone":17,"phoneExt":17,"email":17},{"facility":244,"status":35,"city":245,"state":199,"zip":246,"country":39,"countryCode":40,"cosmosGeoPoint":247,"geoPoint":251,"contacts":252},"Albert Einstein College of Medicine","The Bronx","10461",{"type":42,"coordinates":248},[249,250],-73.86641,40.84985,{"lat":250,"lon":249},[253,257],{"name":254,"role":26,"phone":255,"phoneExt":17,"email":256},"Nicole Maysonet","347-949-3964","einstein-discoverystudy@einsteinmed.edu",{"name":258,"role":54,"phone":17,"phoneExt":17,"email":17},"Carmen R Isasi, MD, PhD",{"facility":260,"status":35,"city":261,"state":262,"zip":263,"country":39,"countryCode":40,"cosmosGeoPoint":264,"geoPoint":268,"contacts":269},"Atrium Health","Charlotte","North Carolina","28207",{"type":42,"coordinates":265},[266,267],-80.84313,35.22709,{"lat":267,"lon":266},[270,274],{"name":271,"role":26,"phone":272,"phoneExt":17,"email":273},"Merischia Griffin","704-446-4804","pediatricresearch@atriumhealth.org",{"name":275,"role":54,"phone":17,"phoneExt":17,"email":17},"Christine Turley, MD",{"facility":277,"status":35,"city":278,"state":262,"zip":279,"country":39,"countryCode":40,"cosmosGeoPoint":280,"geoPoint":284,"contacts":285},"Wake Forest University","Winston-Salem","27157",{"type":42,"coordinates":281},[282,283],-80.24422,36.09986,{"lat":283,"lon":282},[286,290],{"name":287,"role":26,"phone":288,"phoneExt":17,"email":289},"Alisha Davis","336-713-3132","Discovery_Study@wakehealth.edu",{"name":291,"role":54,"phone":17,"phoneExt":17,"email":17},"Elizabeth Jensen, PhD",{"facility":293,"status":35,"city":294,"state":295,"zip":296,"country":39,"countryCode":40,"cosmosGeoPoint":297,"geoPoint":301,"contacts":302},"Cincinnati Children's Hospital","Cincinnati","Ohio","45229",{"type":42,"coordinates":298},[299,300],-84.51439,39.12711,{"lat":300,"lon":299},[303,307,310],{"name":304,"role":26,"phone":305,"phoneExt":17,"email":306},"Hailey Eisenmann","513-803-6708","discoveryinteens@cchmc.org",{"name":308,"role":26,"phone":17,"phoneExt":17,"email":309},"Allen Riegler","Allen.Riegler@cchmc.org",{"name":311,"role":54,"phone":17,"phoneExt":17,"email":17},"Amy S Shah, MD, MS",{"facility":313,"status":35,"city":314,"state":295,"zip":315,"country":39,"countryCode":40,"cosmosGeoPoint":316,"geoPoint":320,"contacts":321},"Nationwide Children's Hospital","Columbus","43205",{"type":42,"coordinates":317},[318,319],-82.99879,39.96118,{"lat":319,"lon":318},[322,326,328],{"name":323,"role":26,"phone":324,"phoneExt":17,"email":325},"Jacqueline Brito","614-722-8528","Jacqueline.brito@nationwidechildrens.org",{"name":327,"role":54,"phone":17,"phoneExt":17,"email":17},"Robert P Hoffman, MD",{"name":329,"role":54,"phone":17,"phoneExt":17,"email":17},"Ihuoma Eneli, MBBS",{"facility":331,"status":35,"city":332,"state":333,"zip":334,"country":39,"countryCode":40,"cosmosGeoPoint":335,"geoPoint":339,"contacts":340},"The University of Oklahoma Health Sciences Center","Oklahoma City","Oklahoma","73104",{"type":42,"coordinates":336},[337,338],-97.51643,35.46756,{"lat":338,"lon":337},[341,345],{"name":342,"role":26,"phone":343,"phoneExt":17,"email":344},"Jeff Preske","405-271-7554","discoverystudy@ou.edu",{"name":346,"role":54,"phone":17,"phoneExt":17,"email":17},"Jeanie B Tryggestad, MD",{"facility":348,"status":35,"city":349,"state":350,"zip":351,"country":39,"countryCode":40,"cosmosGeoPoint":352,"geoPoint":356,"contacts":357},"Children's Hospital of Philadelphia","Philadelphia","Pennsylvania","19104",{"type":42,"coordinates":353},[354,355],-75.16362,39.95238,{"lat":355,"lon":354},[358,362,365],{"name":359,"role":26,"phone":360,"phoneExt":17,"email":361},"Sarah Loughran","215-590-2134","DISCOVERYSTUDY@CHOP.EDU",{"name":363,"role":26,"phone":17,"phoneExt":17,"email":364},"Beth Schwartzman","schwartzmann@chop.edu",{"name":366,"role":54,"phone":17,"phoneExt":17,"email":17},"Lorraine E Levitt Katz, MD",{"facility":368,"status":35,"city":369,"state":370,"zip":371,"country":39,"countryCode":40,"cosmosGeoPoint":372,"geoPoint":376,"contacts":377},"Baylor College of Medicine \u002F Texas Children's","Houston","Texas","77030",{"type":42,"coordinates":373},[374,375],-95.36327,29.76328,{"lat":375,"lon":374},[378,382,386],{"name":379,"role":26,"phone":380,"phoneExt":17,"email":381},"Jesus Cazares","713-798-7132","jesus.cazares@bcm.edu",{"name":383,"role":26,"phone":384,"phoneExt":17,"email":385},"Dahlia Solorzano","713-798-7125","dahlia.solorzano@bcm.edu",{"name":387,"role":54,"phone":17,"phoneExt":17,"email":17},"Fida Bacha, MD",{"type":54,"investigatorFullName":389,"investigatorTitle":390,"investigatorAffiliation":5,"oldNameTitle":17,"oldOrganization":17},"Barbara Braffett","Associate Professor","100556450",false,"NCT06525259","DISCOVERY of Risk Factors for Type 2 Diabetes in Youth","DISCOVERY","Inclusion Criteria:\n\nScreening will occur to enrich the yield of individuals who are highly predisposed to develop youth-onset T2D and include those with all of the following criteria:\n\n* Overweight or obesity with BMI ≥85th percentile\n* Age 8-13 year for girls, 9-15 year for boys (inclusion younger for girls as puberty tends to start a year earlier in girls)\n* Tanner Stage 2, 3, or 4\n* Elevated HbA1c 5.5-6.4%\n\nExclusion Criteria:\n\nAn individual who meets any of the following criteria will be excluded from participation:\n\n* Diabetes based on history, or HbA1c ≥6.5% in the medical record or at screening\n* Unable\u002Funwilling to provide consent\u002Fparticipate fully\n* Conditions predisposing to diabetes or altering the trajectory of puberty\n* Medications affecting glucose dynamics during the screening and enrollment period\n* Prior treatment with insulin\n* Use of glucagon-like peptide-1 (GLP-1) receptor agonist or any weight loss medications in the 6 weeks prior to enrollment\n* Planning treatment with glucagon-like peptide-1 (GLP-1) receptor agonist or any weight loss medications\n* Use of metformin or any glucose lowering medication for a reason other than treatment of diabetes (e.g., for PCOS) in the 6 weeks prior to enrollment\n* Planning treatment with metformin or any glucose lowering medication or planning to use such medications for a reason other than treatment of diabetes (e.g., for PCOS)\n* Known syndromic\u002Fmonogenic obesity\n* Blood disorders impacting HbA1c (e.g., anemia, hemoglobin variants)\n* Major systemic organ disease\n* History of bariatric surgery or currently planning bariatric surgery\n* Current pregnancy or currently planning pregnancy\n* Use of GnRH agonist, estrogen, or testosterone\n* Individuals who do not speak English or Spanish, given validation of the questionnaires to be utilized","ALL","8 Years","15 Years",{"count":401,"type":402},3600,"ESTIMATED","OBSERVATIONAL","The goal of the DISCOVERY study is to provide innovative critical information regarding the unique natural history of glycemic control, insulin sensitivity, and β-cell function, and their mechanistic determinates, in obese adolescents at risk for developing type 2 diabetes.",[406],"Diabetes Mellitus Type 2, Childhood-Onset","2026-05-06",{"date":409,"type":410},"2026-05-07","ACTUAL",{"date":412,"type":410},"2024-10-01",{"date":414,"type":402},"2028-01-31",{"name":5,"class":6},20]