Does RPNI Reduce Incidence of Neuroma Formation Following Sural Nerve Biopsy

Trial statusNot yet recruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18+
SponsorUniversity of British Columbia

About this trial

The purpose of our project is to determine if incorporating preventative surgical techniques such as regenerative peripheral nerve interfaces (RPNI) into sural nerve biopsy can reduce the incidence of symptomatic neuroma formation. Findings from this study will inform best practice guidelines and can dramatically impact patient care, improve patient quality of life, and reduce the number of required repeat operations.

Eligibility criteria

Qualifiers

Patient 18 years old and older who are referred for sural nerve and muscle biopsy to the University of British Columbia Division of Plastic Surgery from January 2025 onwards for diagnostic or prognostic clarification of a medical condition.

Disqualifiers

Patients with previous nerve trauma (traumatic injury, surgery, or repeat biopsy) of biopsied nerve.

Trial design

Treatments tested in this trial

  • Peripheral Nerve Regenerative Interface (RPNI) and Nerve/Muscle Biopsy
  • Biopsy Alone

Treatment groups

20 Participants
are divided into 2 treatment groups

Locations

3
Saint Pauls HospitalV6Z 1Y6, VancouverBritish Columbia, Canada
UBC Division of Plastic SurgeryV5Z1M9, VancouverBritish Columbia, Canada
Vancouver General HospitalV5Z1M9, VancouverBritish Columbia, Canada

Sponsors and collaborators

University of British Columbia

Lead sponsor