[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100601380":3},{"organization":4,"outcomesModule":7,"designInfo":14,"detailedDescription":13,"studyPopulation":13,"armGroups":20,"interventions":33,"overallOfficials":39,"centralContacts":43,"locations":49,"responsibleParty":65,"collaborators":13,"id":67,"slug":13,"hasResults":68,"nctId":69,"briefTitle":70,"officialTitle":70,"acronym":13,"eligibilityCriteria":71,"healthyVolunteers":68,"sex":72,"minAge":73,"maxAge":13,"enrollmentInfo":74,"targetDuration":13,"studyType":77,"phases":78,"briefSummary":80,"conditions":81,"keywords":13,"overallStatus":51,"whyStopped":13,"lastUpdateSubmitDate":84,"lastUpdatePostDateStruct":85,"startDateStruct":88,"completionDateStruct":90,"leadSponsor":92,"locationsCount":93},{"fullName":5,"class":6},"University of Minnesota","OTHER",{"primaryOutcomes":8,"secondaryOutcomes":13,"otherOutcomes":13},[9],{"measure":10,"description":11,"timeFrame":12},"Systolic Blood Pressure at 6 Weeks","To determine resting SBP before and after 6 weeks of IMST 15, IMST 30, or IMST 45 (75% PI max for all groups) in men and women aged ≥18 years with resting SBP ≥120 mmHg.","Week 6",null,{"allocation":15,"interventionModel":16,"interventionModelDescription":13,"primaryPurpose":17,"observationalModel":13,"timePerspective":13,"maskingInfo":18},"RANDOMIZED","PARALLEL","TREATMENT",{"masking":19,"maskingDescription":13,"whoMasked":13},"NONE",[21,27,30],{"label":22,"type":23,"description":24,"interventionNames":25},"15 Breaths\u002F Day","ACTIVE_COMPARATOR","All sessions will be performed at 75% of each participant's PI max 7 days per week, for 6 weeks, using the POWERbreathe K5 device. Each session will take approximately 3-10 minutes depending on the assigned dose group.",[26],"Device: POWERbreathe K5",{"label":28,"type":23,"description":24,"interventionNames":29},"30 Breaths\u002F Day",[26],{"label":31,"type":23,"description":24,"interventionNames":32},"45 Breaths\u002F Day",[26],[34],{"type":35,"name":36,"description":37,"armGroupLabels":38,"otherNames":13},"DEVICE","POWERbreathe K5","The POWERbreathe K5 is portable, battery-powered, and commercially available. No modifications to the FDA-approved design are being made. Its use in this study is consistent with prior published human research and does not constitute a significant deviation from labeled use in terms of safety or function.",[22,28,31],[40],{"name":41,"affiliation":5,"role":42},"Daniel Craighead, PhD","PRINCIPAL_INVESTIGATOR",[44],{"name":45,"role":46,"phone":47,"phoneExt":13,"email":48},"Hannah Westerberg","CONTACT","612-624-1588","lewi1241@umn.edu",[50],{"facility":5,"status":51,"city":52,"state":53,"zip":54,"country":55,"countryCode":56,"cosmosGeoPoint":57,"geoPoint":62,"contacts":63},"RECRUITING","Minneapolis","Minnesota","55455","United States","US",{"type":58,"coordinates":59},"Point",[60,61],-93.26384,44.97997,{"lat":61,"lon":60},[64],{"name":45,"role":46,"phone":47,"phoneExt":13,"email":48},{"type":66,"investigatorFullName":13,"investigatorTitle":13,"investigatorAffiliation":13,"oldNameTitle":13,"oldOrganization":13},"SPONSOR","100601380",false,"NCT07109739","Dose-Response Effects of Inspiratory Muscle Strength Training on Blood Pressure and Vascular Function","Inclusion Criteria:\n\n* Age ≥18 years\n* Resting SBP ≥120 mmHg as measured during screening 1 \\& 2\n* Free from serious CV or metabolic diseases as identified by self-report and blood chemistry analysis.\n* No contraindications to IMST (recent abdominal surgery, ruptured eardrum, asthma with very low symptom perception, fractured ribs, or pneumothorax)\n* Language: English-speaking, with ability to comprehend study materials and instructions.\n* Pre-visit Compliance: Willing to comply with pre-visit instructions (avoiding food and caffeine ≥ 3 hours, vigorous exercise, alcohol, and non-prescribed medications ≥ 24 hours) prior to each measurement visit.\n* Lifestyle: Non-smokers (defined as self-report of not smoking cigarettes or vaping over the past year).\n\nExclusion Criteria:\n\n* Self-report of history of cardiovascular disease, or conditions affecting the ear (e.g., ruptured eardrum).\n* Recent abdominal surgery or presence of an abdominal hernia.\n* Asthma with very low symptom perception, frequent severe exacerbations, or abnormally low perception of dyspnea.\n* Ruptured eardrum or any other condition of the ear.\n* Markedly elevated left ventricular end-diastolic volume and pressure.\n* Current respiratory conditions such as a cold, sinusitis, or respiratory tract infection (participants may be included once they recover from the respiratory condition).\n* Female-Specific: Pregnant or planning to become pregnant during the study period.\n* Compliance: Unable or unwilling to comply with pre-visit restrictions (e.g., avoiding caffeine, alcohol, and exercise within specified hours before visits).","ALL","18 Years",{"count":75,"type":76},144,"ESTIMATED","INTERVENTIONAL",[79],"NA","This study will assess the dose-response effects of Inspiratory Muscle Strength Training (IMST) in adults with above-normal systolic blood pressure over a 6-week period.",[82,83],"Systolic Hypertension","Brachial Artery Flow-mediated Dilation","2025-11-24",{"date":86,"type":87},"2025-11-25","ACTUAL",{"date":89,"type":87},"2025-10-24",{"date":91,"type":76},"2027-03-31",{"name":5,"class":6},1]