[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100573118":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":31,"centralContacts":35,"locations":41,"responsibleParty":58,"collaborators":60,"id":70,"slug":26,"hasResults":71,"nctId":72,"briefTitle":73,"officialTitle":73,"acronym":74,"eligibilityCriteria":75,"healthyVolunteers":71,"sex":76,"minAge":77,"maxAge":26,"enrollmentInfo":78,"targetDuration":26,"studyType":81,"phases":82,"briefSummary":84,"conditions":85,"keywords":87,"overallStatus":43,"whyStopped":26,"lastUpdateSubmitDate":91,"lastUpdatePostDateStruct":92,"startDateStruct":95,"completionDateStruct":97,"leadSponsor":99,"locationsCount":100},{"fullName":5,"class":6},"Second Affiliated Hospital, School of Medicine, Zhejiang University","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"DCB group","EXPERIMENTAL","STEMI patients undergo revascularization using DCB",[13],"Device: Drug-coated balloon (DCB)",{"label":15,"type":16,"description":17,"interventionNames":18},"DES group","ACTIVE_COMPARATOR","STEMI patients undergo revascularization using DES",[19],"Device: Drug-eluting stent (DES)",[21,27],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"DEVICE","Drug-coated balloon (DCB)","Drug-coated balloon treatment of target lesions in patients with STEMI undergoing percutaneous coronary intervention.",[9],null,{"type":22,"name":28,"description":29,"armGroupLabels":30,"otherNames":26},"Drug-eluting stent (DES)","Drug-eluting stent treatment of target lesions in patients with STEMI undergoing percutaneous coronary intervention.",[15],[32],{"name":33,"affiliation":5,"role":34},"Jun Jiang","STUDY_DIRECTOR",[36],{"name":37,"role":38,"phone":39,"phoneExt":26,"email":40},"Jucheng Zhang","CONTACT","+8618768146640","jucheng@zju.edu.cn",[42],{"facility":5,"status":43,"city":44,"state":45,"zip":26,"country":46,"cosmosGeoPoint":47,"geoPoint":52,"contacts":53},"RECRUITING","Hangzhou","Zhejiang","China",{"type":48,"coordinates":49},"Point",[50,51],120.16142,30.29365,{"lat":51,"lon":50},[54],{"name":55,"role":38,"phone":56,"phoneExt":26,"email":57},"Chi Liu","+8615950550839","liuchi1011@163.com",{"type":59,"investigatorFullName":26,"investigatorTitle":26,"investigatorAffiliation":26,"oldNameTitle":26,"oldOrganization":26},"SPONSOR",[61,63,65,67],{"name":62,"class":6},"The First Affiliated Hospital of Zhengzhou University",{"name":64,"class":6},"Peking University First Hospital",{"name":66,"class":6},"Suzhou Municipal Hospital",{"name":68,"class":69},"First Affiliated Hospital of Ningbo University","NETWORK","100573118",false,"NCT06742125","Drug-Coated Balloon Versus Drug-Eluting Stent in Patient With ST-Segment Elevation Myocardial Infarction","DCB-STEMI","Inclusion Criteria:\n\n1. . Age of Patients ≥18 years old;\n2. Acute myocardial infarction patients with onset symptoms\\\u003C48 hours require emergency PCI;\n3. . Diagnosis: Chest pain and other ischemic symptoms accompanied by ST segment elevation in at least two adjacent leads on electrocardiogram (① V2 or V3 lead: male\\\u003C40 years ≥ 0.25mV, ≥ 40 years ≥ 0.2mV; Female ≥1.5mV；② Other leads ≥ 1mV), or new left bundle branch block occurs;\n4. Criminal blood vessels with clear requirements for emergency PCI;\n5. Coronary artery in situ lesions, with a visual reference lumen diameter of ≥ 2mm and ≤ 4mm; Lesion's length\\\u003C40mm；\n6. After thrombus aspiration and pre dilation, the lesion stenosis is ≤ 50% and there is no C-type or above dissection.\n7. He\u002Fshe or his\u002Fher legal representative voluntarily participates in this study and signs an informed consent form.\n\nExclusion Criteria:\n\n1. The patient has allergies or contraindications to the following medications: Heparin, Aspirin, Clopidogrel, Prasugrel, Ticagrelor, Cilostazol, Indobufen, Contrast Medias (Patients with clear contrast agent allergies such as rash but can be controlled with effective drugs such as glucocorticoids and diphenhydramine in advance can be selected);\n2. The patient has active pathological bleeding;\n3. History of significant gastrointestinal or urogenital bleeding or bleeding tendency within 3 months prior to surgery, known coagulation disorders (including heparin induced thrombocytopenia);\n4. Patients who are pregnant or have the intention to become pregnant during the period of research;\n5. Non cardiogenic combined lesions show an expected life expectancy of less than one year;\n6. Left main trunk's stenosis ≥ 50%\n7. History of coronary artery bypass grafting in the past;\n8. Intubation or mechanical ventilation status;\n9. . Cardiogenic Shock\n10. . Without signature on informed consent","ALL","18 Years",{"count":79,"type":80},1244,"ESTIMATED","INTERVENTIONAL",[83],"NA","Acute ST-segment elevation myocardial infarction (STEMI) is a life-threatening emergency requiring immediate intervention. The incidence of premature coronary artery disease (PCAD) is rising rapidly in China; its long-term prognosis remains poor and it frequently progresses to acute myocardial infarction, necessitating high-risk therapies such as primary percutaneous coronary intervention (PCI) or coronary artery bypass grafting, thereby imposing enormous economic and psychological burdens on patients and their families. Moreover, the cumulative 6-year rate of death or myocardial infarction after implantation of the latest-generation drug-eluting stents still reaches 15%, and management of stent failure is extremely challenging. Drug-coated balloon (DCB) angioplasty-representing the \"leave-nothing-behind\" paradigm-is a highly promising option in young subjects. Accumulating clinical evidence demonstrates that DCB provides favorable efficacy across a broad spectrum of lesions, including small-vessel and large-vessel de novo disease, bifurcation lesions, and in-stent restenosis. Nevertheless, high-quality data on the impact of DCB angioplasty in de novo large-vessel disease and in the setting of acute STEMI are still lacking.",[86],"ST-elevation Myocardial Infarction (STEMI)",[88,89,90],"Drug-coated balloon","Drug-eluting stent","ST-elevation myocardial infarction (STEMI)","2026-01-27",{"date":93,"type":94},"2026-01-29","ACTUAL",{"date":96,"type":94},"2025-05-31",{"date":98,"type":80},"2032-01-01",{"name":5,"class":6},1]