Drug Sensitivity Detection of Micro Tumor (PTC) to Guide Postoperative Adjuvant Treatment Strategy of Colorectal Cancer

Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18-75
SponsorPeking Union Medical College Hospital

About this trial

The research objectives is to compare vitro 3D drug sensitivity test results of micro tumor (PTC) with the clinical outcomes of patients, evaluate the consistency between the test results of the technology platform and the clinical prognosis, and explore the decision-making value and guiding significance of this technology in assisting the precise treatment of colorectal cancer. The completion of this study will provide real-world data support for the clinical application of micro tumor (PTC) in vitro 3D drug sensitivity detection technology, and provide more valuable reference basis for realizing the individualization and accuracy of colorectal cancer treatment and improving the clinical benefit rate.

Eligibility criteria

Qualifiers

Age 18 ~ 75 years old, regardless of gender

Patients with colorectal cancer diagnosed by histopathology or cytology

Colorectal cancer patients who need adjuvant therapy after radical surgery and have not received neoadjuvant therapy

Having at least one assessable tumor focus

Disqualifiers

Patients diagnosed with metastasis

Patients who cannot obtain tumor samples

Pregnant and lactating women

Patients with poor compliance

Trial design

Treatments tested in this trial

  • 5-fluorouracil + formyltetrahydrofolate/Oxaliplatin + 5-fluorouracil + formyltetrahydrofolate/Irinotecan + 5-fluorouracil + formyltetrahydrofolate/Cetuximab + 5-fluorouracil + formyltetrahydrofolate

Treatment groups

200 Participants
are divided into 2 treatment groups

Locations

1
Peking Union Medical College Hospital100730, BeijingBeijing Municipality, China

Sponsors and collaborators

Peking Union Medical College Hospital

Lead sponsor