[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100472974":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":25,"centralContacts":35,"locations":44,"responsibleParty":153,"collaborators":156,"id":172,"slug":18,"hasResults":173,"nctId":174,"briefTitle":175,"officialTitle":176,"acronym":177,"eligibilityCriteria":178,"healthyVolunteers":173,"sex":179,"minAge":180,"maxAge":18,"enrollmentInfo":181,"targetDuration":18,"studyType":184,"phases":185,"briefSummary":187,"conditions":188,"keywords":190,"overallStatus":47,"whyStopped":18,"lastUpdateSubmitDate":195,"lastUpdatePostDateStruct":196,"startDateStruct":199,"completionDateStruct":201,"leadSponsor":203,"locationsCount":204},{"fullName":5,"class":6},"Na Homolce Hospital","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Early surgery","EXPERIMENTAL","Early surgical treatment, state of art aortic valve surgery.",[13],"Procedure: State of art aortic valve surgery",{"label":15,"type":16,"description":17,"interventionNames":18},"Watchful waiting","NO_INTERVENTION","Watchful waiting strategy, regular follow-up of patients with severe valve disease. Guideline-based indication for surgery only during the follow-up.",null,[20],{"type":21,"name":22,"description":23,"armGroupLabels":24,"otherNames":18},"PROCEDURE","State of art aortic valve surgery","Optimal surgical treatment (aortic valve-sparing surgery, aortic valve replacement, Ross procedure).",[9],[26,29,32],{"name":27,"affiliation":5,"role":28},"Radka Kočková, MD, PhD","PRINCIPAL_INVESTIGATOR",{"name":30,"affiliation":31,"role":28},"Jan Vojáček, MD, PhD","Faculty Hospital Hradec Králové",{"name":33,"affiliation":34,"role":28},"Martin Pěnička, MD, PhD","Cardiovascular Center OLV Clinic",[36,41],{"name":37,"role":38,"phone":39,"phoneExt":18,"email":40},"Radka Kočková, MD,PhD","CONTACT","+420606483586","radka.kockova@centrum.cz",{"name":30,"role":38,"phone":42,"phoneExt":18,"email":43},"+420777095921","jan.vojacek1@fnhk.cz",[45,61,72,87,102,117,124,139],{"facility":46,"status":47,"city":48,"state":18,"zip":49,"country":50,"cosmosGeoPoint":51,"geoPoint":56,"contacts":57},"Cardiovascular Center OLV Clinic Aalst","RECRUITING","Aalst","9300","Belgium",{"type":52,"coordinates":53},"Point",[54,55],4.0355,50.93604,{"lat":55,"lon":54},[58],{"name":33,"role":38,"phone":59,"phoneExt":18,"email":60},"+32474917532","Martin.Penicka@olvz-aalst.be",{"facility":62,"status":63,"city":64,"state":18,"zip":65,"country":66,"cosmosGeoPoint":67,"geoPoint":71,"contacts":18},"International Clinical Research Center, St. Anne´s University Hospital Brno","ACTIVE_NOT_RECRUITING","Brno","656 91","Czechia",{"type":52,"coordinates":68},[69,70],16.60796,49.19522,{"lat":70,"lon":69},{"facility":73,"status":47,"city":64,"state":18,"zip":74,"country":66,"cosmosGeoPoint":75,"geoPoint":77,"contacts":78},"Center of Cardiovascular and Transplant Surgery","65691",{"type":52,"coordinates":76},[69,70],{"lat":70,"lon":69},[79,83],{"name":80,"role":38,"phone":81,"phoneExt":18,"email":82},"Helena Bedáňová, MD, PhD","+420543182519","hbedanova@seznam.cz",{"name":84,"role":38,"phone":85,"phoneExt":18,"email":86},"Petr Fila, MD, PhD","+420543182514","petr.fila@cktch.cz",{"facility":88,"status":47,"city":89,"state":18,"zip":90,"country":66,"cosmosGeoPoint":91,"geoPoint":95,"contacts":96},"University Hospital Hradec Králové","Hradec Králové","50005",{"type":52,"coordinates":92},[93,94],15.83277,50.20923,{"lat":94,"lon":93},[97,98],{"name":30,"role":38,"phone":42,"phoneExt":18,"email":43},{"name":99,"role":38,"phone":100,"phoneExt":18,"email":101},"Karel Mědílek, MD","+420495833873","karel.medilek@fnhk.cz",{"facility":103,"status":47,"city":104,"state":18,"zip":105,"country":66,"cosmosGeoPoint":106,"geoPoint":110,"contacts":111},"2nd Department of Internal Cardiovascular Medicine, First Faculty of Medicine, Charles University and General University Hospital in Prague","Prague","128 08",{"type":52,"coordinates":107},[108,109],14.42076,50.08804,{"lat":109,"lon":108},[112,116],{"name":113,"role":38,"phone":114,"phoneExt":18,"email":115},"Zuzana Hlubocká, M.D., Ph.D.","+420 22496 2634","Zuzana.Hlubocka@vfn.cz",{"name":113,"role":28,"phone":18,"phoneExt":18,"email":18},{"facility":5,"status":47,"city":104,"state":18,"zip":118,"country":66,"cosmosGeoPoint":119,"geoPoint":121,"contacts":122},"150 30",{"type":52,"coordinates":120},[108,109],{"lat":109,"lon":108},[123],{"name":27,"role":38,"phone":39,"phoneExt":18,"email":40},{"facility":125,"status":47,"city":126,"state":18,"zip":127,"country":66,"cosmosGeoPoint":128,"geoPoint":132,"contacts":133},"Nemocnice AGEL Třinec-Podlesí","Třinec","73961",{"type":52,"coordinates":129},[130,131],18.67078,49.67763,{"lat":131,"lon":130},[134],{"name":135,"role":38,"phone":136,"phoneExt":137,"email":138},"Veronika Kubančáková, MD","722972854","+420","veronika.kubancakova@npo.agel.cz",{"facility":140,"status":47,"city":141,"state":18,"zip":142,"country":143,"cosmosGeoPoint":144,"geoPoint":148,"contacts":149},"University Clinical Center of Serbia","Belgrade","11000","Serbia",{"type":52,"coordinates":145},[146,147],20.46513,44.80401,{"lat":147,"lon":146},[150],{"name":151,"role":38,"phone":18,"phoneExt":18,"email":152},"Marko Banovic, MD, Ph.D.","markobanovic71@gmail.com",{"type":28,"investigatorFullName":154,"investigatorTitle":155,"investigatorAffiliation":5,"oldNameTitle":18,"oldOrganization":18},"Radka Kockova, MD, Ph.D.","Associate Professor",[157,159,161,163,165,167,169],{"name":158,"class":6},"University Hospital Hradec Kralove",{"name":160,"class":6},"Centre of Cardiovascular and Transplantation Surgery, Czech Republic",{"name":162,"class":6},"St. Anne's University Hospital Brno, Czech Republic",{"name":164,"class":6},"VZW Cardiovascular Research Center Aalst",{"name":166,"class":6},"General University Hospital, Prague",{"name":168,"class":6},"University Clinical Centre of Republic of Srpska",{"name":170,"class":171},"AGEL Třinec-Podlesí Hospital","UNKNOWN","100472974",false,"NCT05438862","Early Aortic vaLve surgEry Versus wAtchful waitiNg Strategy in Severe Asymptomatic aOrtic reguRgitation","Early Aortic Valve Surgery Versus Watchful Waiting Strategy in Severe Asymptomatic Aortic Regurgitation","ELEANOR","Inclusion Criteria:\n\n* Chronic asymptomatic aortic regurgitation grade 3 (moderate to severe) and grade 4 (severe)\n* No indication for the surgical treatment at the time of enrolment\n* LV ejection fraction \\>50%\n* Absence of more than mild-to-moderate concomitant valve disease or complex congenital heart disease\n\nExclusion Criteria:\n\n* Age \\\u003C18 years\n* Clearance Creatinine \\\u003C30 mL\u002Fmin\n* Contraindication for magnetic resonance (implanted active device, ferromagnetic implant incompatible with magnetic resonance scanner, cerebral aneurysm clip, metallic fragment in the eye or near sensitive tissue)\n* Pregnancy\n* Permanent atrial fibrillation.","ALL","18 Years",{"count":182,"type":183},217,"ESTIMATED","INTERVENTIONAL",[186],"NA","The optimal timing of surgical intervention in asymptomatic patients with severe aortic regurgitation remains controversial. As per cardiac magnetic resonance assessment, early surgical treatment will be compared with conventional guideline-based strategy in asymptomatic patients with severe aortic regurgitation.",[189],"Aortic Valve Regurgitation",[191,192,193,194],"aortic regurgitation","cardiac magnetic resonance","echocardiography","early surgical intervention","2026-02-13",{"date":197,"type":198},"2026-02-17","ACTUAL",{"date":200,"type":198},"2022-09-01",{"date":202,"type":183},"2027-12-31",{"name":5,"class":6},8]