Health Trials

Early Detection of Advanced Adenomas and Colorectal Cancer

ConditionsColorectal CancerColorectal NeoplasmsColorectal PolypColorectal AdenocarcinomaColorectal DisordersColorectal DysplasiaColorectal Cancer Stage IColorectal Cancer Stage IIColorectal Cancer Stage IIIColorectal Cancer Stage IVColorectal Neoplasms MalignantColorectal Serrated AdenocarcinomaColorectal Adenoma With Severe DysplasiaColorectal Adenoma With Mild DysplasiaColorectal Adenoma With Moderate DysplasiaColorectal Adenoma and Carcinoma 1Colorectal Adenomatous PolypColorectal Adenocarcinoma Metastatic in the Liver
Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age18+
SponsorCity of Hope Medical Center

About this trial

This study aims to develop a highly sensitive, specific, and cost-effective blood assay for early detection of colorectal adenomas and cancer, using advanced machine learning and state-of-the-art biological analyses.

Eligibility criteria

Qualifiers

All individuals included in the study need to have had a colonoscopy at the time of blood sampling.

Received standard diagnostic and staging (as necessary) procedures as per local guidelines, and at least one sample was drawn before receiving any curative-intent treatment.

Received standard pathological and endoscopic diagnosis and assessment for cohort assignment.

Disqualifiers

Hereditary colorectal cancer syndromes (identified through genetic testing).

Inflammatory bowel diseases.

Lack of written informed consent.

Trial design

Treatments tested in this trial

  • DENEB

Treatment groups

2,000 Participants
are divided into 12 treatment groups

12

Treatment groups

See each treatment group below.

Locations

6
China
The First Affiliated Hospital of Dalian Medical University Dalian China
Italy
IRCCS San Raffaele Milan Italy
Japan
Mie University Mie Japan
Spain
Barcelona University Barcelona Spain

Sponsors and collaborators

City of Hope Medical Center

Lead sponsor

Source ClinicalTrials.gov