[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100544589":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":31,"centralContacts":36,"locations":45,"responsibleParty":73,"collaborators":26,"id":75,"slug":26,"hasResults":76,"nctId":77,"briefTitle":78,"officialTitle":79,"acronym":80,"eligibilityCriteria":81,"healthyVolunteers":82,"sex":83,"minAge":84,"maxAge":85,"enrollmentInfo":86,"targetDuration":26,"studyType":89,"phases":90,"briefSummary":92,"conditions":93,"keywords":95,"overallStatus":64,"whyStopped":26,"lastUpdateSubmitDate":100,"lastUpdatePostDateStruct":101,"startDateStruct":104,"completionDateStruct":106,"leadSponsor":108,"locationsCount":109},{"fullName":5,"class":6},"University Hospital, Basel, Switzerland","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Verum (natural odour)","ACTIVE_COMPARATOR","Participants will inhale 50 uL of a natural odour contained in mini-inhaler over a period of 15 min.",[13],"Combination Product: Inhalation - Natural Odour",{"label":15,"type":16,"description":17,"interventionNames":18},"Placebo Inhalation","PLACEBO_COMPARATOR","Participants will inhale 50 uL of placebo (propylene glycol) contained in mini-inhaler over a period of 15 min.",[19],"Combination Product: Inhalation - Placebo",[21,27],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"COMBINATION_PRODUCT","Inhalation - Natural Odour","Inhalation of 50 uL of a natural odour via nasal septum mini-inhaler.",[9],null,{"type":22,"name":28,"description":29,"armGroupLabels":30,"otherNames":26},"Inhalation - Placebo","Inhalation of 50 uL of Placebo via nasal septum mini-inhaler.",[15],[32],{"name":33,"affiliation":34,"role":35},"Katharina Timper, Prof. Dr. med.","University Hospital Basel, Department of Endocrinology, Diabetology and Metabolism","PRINCIPAL_INVESTIGATOR",[37,41],{"name":33,"role":38,"phone":39,"phoneExt":26,"email":40},"CONTACT","0041 61 328 57 42","katharina.timper@usb.ch",{"name":42,"role":38,"phone":43,"phoneExt":26,"email":44},"Isabel M Hofer","0041 61 328 68 14","Isabelmarie.hofer@usb.ch",[46,62],{"facility":47,"status":48,"city":49,"state":26,"zip":50,"country":51,"cosmosGeoPoint":52,"geoPoint":57,"contacts":58},"University Hospital Basel","NOT_YET_RECRUITING","Basel","4031","Switzerland",{"type":53,"coordinates":54},"Point",[55,56],7.57327,47.55839,{"lat":56,"lon":55},[59,60],{"name":33,"role":38,"phone":39,"phoneExt":26,"email":40},{"name":42,"role":38,"phone":43,"phoneExt":26,"email":61},"isabelmarie.hofer@usb.ch",{"facility":63,"status":64,"city":49,"state":26,"zip":50,"country":51,"cosmosGeoPoint":65,"geoPoint":67,"contacts":68},"University Hospital of Basel","RECRUITING",{"type":53,"coordinates":66},[55,56],{"lat":56,"lon":55},[69],{"name":70,"role":38,"phone":71,"phoneExt":26,"email":72},"Lolita Odermatt","+41 61 328 55 20","lolita.odermatt@usb.ch",{"type":74,"investigatorFullName":26,"investigatorTitle":26,"investigatorAffiliation":26,"oldNameTitle":26,"oldOrganization":26},"SPONSOR","100544589",false,"NCT06370845","ABUNDANCE of A NATURAL ODOUR in HUMAN CEREBROSPINAL FLUID AFTER OLFACTORY EXPOSURE - the OLFO-Brain Study","Abundance of a Natural Odour in Human Cerebrospinal Fluid After Olfactory Exposure - the OLFO-Brain Study","OLFO-Brain","Inclusion Criteria Obese Participants:\n\n* Age 18-60 years\n* Written informed consent\n* Scheduled for routine liquor puncture\n* BMI ≥ 30 kg\u002Fm2\n* No proven diagnose of diabetes\n\nInclusion Criteria Lean Participants:\n\n* Age 18-60 years\n* Written informed consent\n* Scheduled for routine liquor puncture\n* BMI 18-25 kg\u002Fm2\n\nExclusion Criteria:\n\n* Known allergy to the natural odour\n* Acute upper respiratory tract infection, acute or chronic sinusitis\n* Present or past surgical intervention of the nasal cavity, the paranasal sinus, the pituitary or the frontal brain\n* Pregnancy\u002Flactation\n* Any kind of severe chronic disease (e.g. severe heart failure, active cancer disease, severe renal impairment with an estimated glomerular filtration rate \\\u003C30 ml\u002Fmin\u002Fm2)\n* Inability to understand the study procedure and to sign the study consent",true,"ALL","18 Years","60 Years",{"count":87,"type":88},32,"ESTIMATED","INTERVENTIONAL",[91],"EARLY_PHASE1","The goal of this clinical trial is to investigate the abundance of a natural odour in human cerebrospinal fluid in obese and lean participants after inhalation thereof. Participants will undergo blood sample collection and inhalation of either a natural odour or placebo through an inhaler in addition to a liquor puncture prescribed in standard of care context.",[94],"Overweight and Obesity",[96,97,98,99],"natural odour Inhalation","RCT","Placebo Controlled","Cerebrospinal Fluid","2026-04-28",{"date":102,"type":103},"2026-05-04","ACTUAL",{"date":105,"type":103},"2026-04-14",{"date":107,"type":88},"2027-10-30",{"name":5,"class":6},2]