[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100517355":3},{"organization":4,"outcomesModule":7,"designInfo":23,"detailedDescription":36,"studyPopulation":22,"armGroups":37,"interventions":50,"overallOfficials":63,"centralContacts":70,"locations":76,"responsibleParty":99,"collaborators":22,"id":101,"slug":22,"hasResults":102,"nctId":103,"briefTitle":104,"officialTitle":105,"acronym":22,"eligibilityCriteria":106,"healthyVolunteers":102,"sex":107,"minAge":108,"maxAge":109,"enrollmentInfo":110,"targetDuration":22,"studyType":113,"phases":114,"briefSummary":116,"conditions":117,"keywords":119,"overallStatus":79,"whyStopped":22,"lastUpdateSubmitDate":124,"lastUpdatePostDateStruct":125,"startDateStruct":128,"completionDateStruct":130,"leadSponsor":132,"locationsCount":133},{"fullName":5,"class":6},"Texas Tech University Health Sciences Center, El Paso","OTHER",{"primaryOutcomes":8,"secondaryOutcomes":13,"otherOutcomes":22},[9],{"measure":10,"description":11,"timeFrame":12},"Recurrence of headache","Subjects will be contacted 72 hrs post treatment to determine if migraine headache has recurred","72-96 hours post treatment",[14,18],{"measure":15,"description":16,"timeFrame":17},"Early recurrence headache and timing","HA severity, location, time since enrollment enrollment,medications","72-96hrs post treatment",{"measure":19,"description":20,"timeFrame":21},"side effects of dexamethasone identified if any","elevation in glucose level, other symptoms associated with corticosteroids","72-96 hrs post treatment",null,{"allocation":24,"interventionModel":25,"interventionModelDescription":26,"primaryPurpose":27,"observationalModel":22,"timePerspective":22,"maskingInfo":28},"RANDOMIZED","PARALLEL","Randomized 1:1 for study drug vs placebo","TREATMENT",{"masking":29,"maskingDescription":30,"whoMasked":31},"QUADRUPLE","study drug pills (dexamethasone or placebo) will be placed in identical colored capsules and then into numbered packets. Only pharmacist will be unblinded.",[32,33,34,35],"PARTICIPANT","CARE_PROVIDER","INVESTIGATOR","OUTCOMES_ASSESSOR","Previous studies have provided evidence that administering steroids in addition to standard migraine headache treatment in the emergency department may reduce the recurrence of the headache within 24-72 hours. The standard migraine treatments in previous studies have been varied and include 5-HT receptor agonists, dopamine antagonists, dihydroergotamine, NSAIDS, and opioid analgesics. The steroids added to the standard treatment have been prednisone and dexamethasone (both IV and oral).\n\nThis is the first study to examine the combination of peripheral nerve block as the primary treatment of migraine followed by oral dexamethasone to prevent recurrence.",[38,44],{"label":39,"type":40,"description":41,"interventionNames":42},"Dexamethasone","EXPERIMENTAL","single oral dose of dexamethasone (8mg)",[43],"Drug: Dexamethasone Oral",{"label":45,"type":46,"description":47,"interventionNames":48},"Placebo","PLACEBO_COMPARATOR","Single oral dose of placebo pill",[49],"Drug: Placebo",[51,58],{"type":52,"name":53,"description":54,"armGroupLabels":55,"otherNames":56},"DRUG","Dexamethasone Oral","Two 4mg pills",[39],[57],"Decadron",{"type":52,"name":45,"description":59,"armGroupLabels":60,"otherNames":61},"2 placebo pills",[45],[62],"Dextrose methyl cellulose",[64,68],{"name":65,"affiliation":66,"role":67},"Susan Watts, PhD.","Texas Tech University Health Sciences Center, Department of Emergency Medicine","STUDY_DIRECTOR",{"name":69,"affiliation":5,"role":67},"Diluma Kariyawasam, MPH",[71],{"name":72,"role":73,"phone":74,"phoneExt":22,"email":75},"Edward Michelson, MD","CONTACT","915 215 4600","edward.michelson@ttuhsc.edu",[77],{"facility":78,"status":79,"city":80,"state":81,"zip":82,"country":83,"countryCode":84,"cosmosGeoPoint":85,"geoPoint":90,"contacts":91},"University Medical Center of El Paso","RECRUITING","El Paso","Texas","79905","United States","US",{"type":86,"coordinates":87},"Point",[88,89],-106.48693,31.75872,{"lat":89,"lon":88},[92,96],{"name":93,"role":73,"phone":94,"phoneExt":22,"email":95},"Leann Rodriguez","(915) 215-4976","rod72863@ttuhsc.edu",{"name":97,"role":98,"phone":22,"phoneExt":22,"email":22},"Edward A Michelson, MD","PRINCIPAL_INVESTIGATOR",{"type":98,"investigatorFullName":72,"investigatorTitle":100,"investigatorAffiliation":5,"oldNameTitle":22,"oldOrganization":22},"Professor and Chair Dept of Emergency Medicine","100517355",false,"NCT06016465","Does Nerve Block + Oral Dexamethasone Reduce Recurrence of Headache Within 72 Hrs?","Does Nerve Block Plus Oral Dexamethasone Reduce Recurrence of Headache Within 72 Hours Better Than Nerve Block Alone?","Inclusion Criteria:\n\n* Meet ICHD-3 Migraine Headache Criteria\n* Had a minimum 5-point reduction in headache intensity after nerve block(s) or post- block pain score of 0 to 2\n* Nerve block performed with bupivacaine 0.5%\n\nExclusion Criteria:\n\n* Head trauma\n* Suspicion of secondary headache (i.e. stroke, known tumor, glaucoma)\n* Headache in the setting of viral syndrome\n* Chronically on steroids\n* Known allergy to dexamethasone\n* Unable to reach the patient by phone or text for follow-up\n* Gestational diabetes or other uncontrolled diabetes\n* Known to be immunocompromised","ALL","18 Years","85 Years",{"count":111,"type":112},84,"ESTIMATED","INTERVENTIONAL",[115],"EARLY_PHASE1","For some patients who come to the emergency department for treatment of a migraine headache, peripheral headache nerve blocks (PHNB) have proven to be an efficient and effective treatment for headache relief. Previous studies have demonstrated that adding steroids as an adjunct treatment to standard migraine treatment can reduce recurrence of headaches in the subsequent few days.",[118],"Migraine",[120,121,122,123],"migraine headache","peripheral nerve block","dexamethasone","steroid treatment","2026-04-30",{"date":126,"type":127},"2026-05-06","ACTUAL",{"date":129,"type":127},"2023-09-15",{"date":131,"type":112},"2028-01-30",{"name":5,"class":6},1]