[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100553405":3},{"organization":4,"armGroups":7,"interventions":13,"overallOfficials":19,"centralContacts":24,"locations":34,"responsibleParty":51,"collaborators":10,"id":53,"slug":10,"hasResults":54,"nctId":55,"briefTitle":56,"officialTitle":57,"acronym":10,"eligibilityCriteria":58,"healthyVolunteers":54,"sex":59,"minAge":60,"maxAge":10,"enrollmentInfo":61,"targetDuration":10,"studyType":64,"phases":65,"briefSummary":67,"conditions":68,"keywords":10,"overallStatus":37,"whyStopped":10,"lastUpdateSubmitDate":70,"lastUpdatePostDateStruct":71,"startDateStruct":74,"completionDateStruct":76,"leadSponsor":78,"locationsCount":79},{"fullName":5,"class":6},"Ain Shams University","OTHER",[8],{"label":9,"type":6,"description":10,"interventionNames":11},"Duchenne patients subjected to captopril",null,[12],"Drug: Captopril Tablets",[14],{"type":15,"name":16,"description":17,"armGroupLabels":18,"otherNames":10},"DRUG","Captopril Tablets","Patients will be given captopril to see effect on global longitudinal strain",[9],[20],{"name":21,"affiliation":22,"role":23},"Mona Mostafa Rayan, MD","Professor of cardiology -Ain Shams university","PRINCIPAL_INVESTIGATOR",[25,30],{"name":26,"role":27,"phone":28,"phoneExt":10,"email":29},"Fatma Ebeid, MD","CONTACT","00201095569596","dr.fatma_ebeid@yahoo.com",{"name":31,"role":27,"phone":32,"phoneExt":10,"email":33},"Sandra M Mina","01060781869","sandramourad922@yahoo.com",[35],{"facility":36,"status":37,"city":38,"state":10,"zip":10,"country":39,"cosmosGeoPoint":40,"geoPoint":45,"contacts":46},"Ain Shams university","RECRUITING","Cairo","Egypt",{"type":41,"coordinates":42},"Point",[43,44],31.24967,30.06263,{"lat":44,"lon":43},[47,48,49],{"name":26,"role":27,"phone":28,"phoneExt":10,"email":29},{"name":31,"role":27,"phone":32,"phoneExt":10,"email":33},{"name":50,"role":23,"phone":10,"phoneExt":10,"email":10},"Mona M Rayan, MD",{"type":52,"investigatorFullName":10,"investigatorTitle":10,"investigatorAffiliation":10,"oldNameTitle":10,"oldOrganization":10},"SPONSOR","100553405",false,"NCT06485661","Effect of Captopril on GLS in Duchenne Myodystrophy","Intermediate Term Effect of Captopril on Left Ventricle Global Longitudinal Strain in Patients With Duchenne Myodystrophy","Inclusion Criteria:\n\n* Genetically confirmed Duchenne myodystrophy (DMD) patients with abnormal GLS \\\u003C -18% with minimum age of 6 years old.\n\nExclusion Criteria:\n\n* Any patient who refuses to sign an informed consent.\n* Contraindication to ACEI: hypersensitivity - renal impairment - bilateral renal artery stenosis - aortic valve stenosis - hyperkalemia - hypotension.\n* Reduced ejection fraction below 50%.","MALE","6 Years",{"count":62,"type":63},20,"ESTIMATED","INTERVENTIONAL",[66],"EARLY_PHASE1","To outline the intermediate term effect of prescribing Captopril as an add on therapy on Left ventricular functions as measured by Global longitudinal strain in patients with Duchenne myodystrophy (DMD)",[69],"Effect of Drug","2024-07-13",{"date":72,"type":73},"2024-07-16","ACTUAL",{"date":75,"type":73},"2024-01-01",{"date":77,"type":63},"2024-09-30",{"name":5,"class":6},1]