[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100548144":3},{"organization":4,"armGroups":7,"interventions":24,"overallOfficials":30,"centralContacts":39,"locations":45,"responsibleParty":63,"collaborators":30,"id":67,"slug":30,"hasResults":68,"nctId":69,"briefTitle":70,"officialTitle":70,"acronym":30,"eligibilityCriteria":71,"healthyVolunteers":72,"sex":73,"minAge":74,"maxAge":75,"enrollmentInfo":76,"targetDuration":30,"studyType":79,"phases":80,"briefSummary":82,"conditions":83,"keywords":30,"overallStatus":47,"whyStopped":30,"lastUpdateSubmitDate":87,"lastUpdatePostDateStruct":88,"startDateStruct":91,"completionDateStruct":93,"leadSponsor":95,"locationsCount":96},{"fullName":5,"class":6},"University of Missouri-Columbia","OTHER",[8,16,20],{"label":9,"type":10,"description":11,"interventionNames":12},"Hypoxia","EXPERIMENTAL","Participants will be exposed to hypoxia (low oxygen air) using a mask.",[13,14,15],"Drug: Placebo","Drug: Propranolol","Drug: Gemtesa",{"label":17,"type":10,"description":18,"interventionNames":19},"Cold pressor test","Participants will be exposed to the cold pressor test (ice water on the foot).",[13,14,15],{"label":21,"type":10,"description":22,"interventionNames":23},"Hypercapnia","Participants will be exposed to hypercapnia (high carbon dioxide air) using a mask.",[13,14,15],[25,31,35],{"type":26,"name":27,"description":28,"armGroupLabels":29,"otherNames":30},"DRUG","Placebo","Participants will receive a placebo in pill form.",[17,21,9],null,{"type":26,"name":32,"description":33,"armGroupLabels":34,"otherNames":30},"Propranolol","Participants will receive oral propranolol (1 mg\u002Fkg).",[17,21,9],{"type":26,"name":36,"description":37,"armGroupLabels":38,"otherNames":30},"Gemtesa","Participants will receive oral gemtesa (75 mg).",[17,21,9],[40],{"name":41,"role":42,"phone":43,"phoneExt":30,"email":44},"Jacqueline Limberg","CONTACT","573-882-2544","limberglab@missouri.edu",[46],{"facility":5,"status":47,"city":48,"state":49,"zip":50,"country":51,"cosmosGeoPoint":52,"geoPoint":57,"contacts":58},"RECRUITING","Columbia","Missouri","65211","United States",{"type":53,"coordinates":54},"Point",[55,56],-92.33407,38.95171,{"lat":56,"lon":55},[59],{"name":60,"role":42,"phone":61,"phoneExt":30,"email":62},"Jacqueline K Limberg, Ph.D.","573-882-2420","limbergj@missouri.edu",{"type":64,"investigatorFullName":65,"investigatorTitle":66,"investigatorAffiliation":5,"oldNameTitle":30,"oldOrganization":30},"PRINCIPAL_INVESTIGATOR","Jacqueline K Limberg, PhD","Associate Professor","100548144",false,"NCT06417177","Impact of Early Aging and Menopause on the Vascular Responses to Hypoxia","Inclusion Criteria:\n\n* Female assigned at birth\n* Pre, peri- or post-menopausal\n* Healthy weight (BMI ≥18 and ≤30 kg\u002Fm2)\n\nExclusion Criteria:\n\n* Male (assigned at birth)\n* Pregnancy, breastfeeding\n* Use of hormone replacement therapies\n* Hysterectomy\n* Body mass index \\>30 kg\u002Fm2\n* Diagnosed sleep apnea\n* Current smoking\u002FNicotine\u002FDrug use\n* Nerve\u002Fneurologic disease\n* Cardiovascular, hepatic, renal, respiratory disease\n* Blood pressure ≥140\u002F90 mmHg\n* Diabetes, Polycystic ovarian syndrome\n* Communication barriers\n* Prescription medications\n* Malignant cancer",true,"FEMALE","18 Years","70 Years",{"count":77,"type":78},75,"ESTIMATED","INTERVENTIONAL",[81],"EARLY_PHASE1","The purpose of this study is to examine hypoxic vasodilation and the role of beta-adrenergic receptors in younger premenopausal, perimenopausal, and older postmenopausal women.",[84,85,9,86],"Aging","Menopause","Vasodilation","2025-09-08",{"date":89,"type":90},"2025-09-09","ACTUAL",{"date":92,"type":90},"2024-06-03",{"date":94,"type":78},"2026-07",{"name":5,"class":6},1]