Interplay of Central and Peripheral Vascular Effects of Insulin in Obesity
Trial statusNot yet recruiting
Trial phaseEarly Phase 1
Trial typeInterventional
Biological sexAll
Age18-65
SponsorUniversity of Missouri-Columbia
About this trial
In the present study, we seek to determine the impact of obesity with insulin resistance on the neurovascular response to brain insulin stimulation.
Eligibility criteria
Qualifiers
18 to 65 years of age
BMI 30-45 kg/m2
Waist circumference ≥102 cm (men) or ≥88 cm (women)
HOMA-IR ≥2.5
Disqualifiers
Pregnancy, breastfeeding
Unable to provide consent
Diabetes or polycystic ovarian syndrome
Known history of cardiovascular disease: heart failure, ischemic heart disease, peripheral artery disease, stroke
Trial design
Treatments tested in this trial
- human insulin
Treatment groups
64 Participants
are divided into 2 treatment groupsLocations
1University of Missouri65211, ColumbiaMissouri, United States
Sponsors and collaborators
University of Missouri-Columbia
Lead sponsor
Source ClinicalTrials.gov