[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100530033":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":27,"centralContacts":28,"locations":34,"responsibleParty":50,"collaborators":53,"id":56,"slug":27,"hasResults":57,"nctId":58,"briefTitle":59,"officialTitle":60,"acronym":27,"eligibilityCriteria":61,"healthyVolunteers":57,"sex":62,"minAge":63,"maxAge":64,"enrollmentInfo":65,"targetDuration":27,"studyType":68,"phases":69,"briefSummary":71,"conditions":72,"keywords":75,"overallStatus":37,"whyStopped":27,"lastUpdateSubmitDate":82,"lastUpdatePostDateStruct":83,"startDateStruct":86,"completionDateStruct":88,"leadSponsor":90,"locationsCount":91},{"fullName":5,"class":6},"University of Nicosia","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Probiotics","EXPERIMENTAL","Participants received 1 capsule daily of probiotics, administered orally for 16 weeks.",[13],"Drug: Probiotic Blend Capsule",{"label":15,"type":16,"description":17,"interventionNames":18},"Placebo","PLACEBO_COMPARATOR","Participants received 1 capsule daily of placebo, administered orally for 16 weeks.",[13],[20],{"type":21,"name":22,"description":23,"armGroupLabels":24,"otherNames":25},"DRUG","Probiotic Blend Capsule","20 million CFU (Lactobacillus paracasei, Lactobacillus plantarum, Lactobacillus rhamnosus, Lactobacillus helveticus, Bifidobacterium breve)",[15,9],[26],"Ultrabiotique Equilibre 30 Vitavea",null,[29],{"name":30,"role":31,"phone":32,"phoneExt":27,"email":33},"Nicoletta Nicolaou","CONTACT","+35722471903","nicolaou.nic@unic.ac.cy",[35],{"facility":36,"status":37,"city":38,"state":27,"zip":27,"country":39,"cosmosGeoPoint":40,"geoPoint":45,"contacts":46},"The Cyprus Institute of Neurology and Genetics","RECRUITING","Nicosia","Cyprus",{"type":41,"coordinates":42},"Point",[43,44],33.35397,35.17284,{"lat":44,"lon":43},[47],{"name":48,"role":31,"phone":27,"phoneExt":27,"email":49},"Ioanna Kousiappa","ioannak@cing.ac.cy",{"type":51,"investigatorFullName":30,"investigatorTitle":52,"investigatorAffiliation":5,"oldNameTitle":27,"oldOrganization":27},"PRINCIPAL_INVESTIGATOR","Associate Professor",[54],{"name":55,"class":6},"Cyprus Institute of Neurology and Genetics","100530033",false,"NCT06181513","Probiotics in Mild Alzheimer's Disease","Effect of Probiotics on Cognitive Functioning of Patients With Mild Alzheimer's Disease","Inclusion Criteria:\n\n* Adults ≥65 years, able to give consent\n* Mini-Mental State Examination (MMSE) scores 19-23 (mild AD)\n* approximately equal male:female ratio\n\nExclusion Criteria:\n\n* Inability to give consent\n* other neurological disease\n* relevant psychiatric disorders (e.g. major depression)\n* gastrointestinal\u002Fmetabolic conditions\n* history of alcohol\u002Fsubstance dependence\n* use of systemic antibiotics in the previous 6 months\n* corticosteroid use\n* immune stimulating medications\n* immunosuppressive agents\n* probiotics consumption in the previous 6 months.\n* immunosuppression\n* structural heart disease\n* neutropenia\n* radiation\n* active intestinal disease","ALL","65 Years","85 Years",{"count":66,"type":67},40,"ESTIMATED","INTERVENTIONAL",[70],"EARLY_PHASE1","The main objective is to investigate whether administration of probiotics to patients with mild Alzheimer's Disease (AD) reduces neuroinflammation, improves cognitive function and modifies neurophysiological measures, compared to a patient group that receives placebo (no active probiotics).",[73,74],"Neurodegenerative Diseases","Cognition Disorders in Old Age",[76,77,78,79,80,81],"probiotics","Electroencephalogram (EEG)","cognitive function","Alzheimer's Disease","neuropsychological testing","Electrocardiogram (EKG)","2024-12-03",{"date":84,"type":85},"2024-12-05","ACTUAL",{"date":87,"type":85},"2022-12-19",{"date":89,"type":67},"2025-12-01",{"name":5,"class":6},1]