[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100592870":3},{"organization":4,"outcomesModule":7,"designInfo":25,"detailedDescription":34,"studyPopulation":24,"armGroups":35,"interventions":54,"overallOfficials":24,"centralContacts":69,"locations":78,"responsibleParty":95,"collaborators":24,"id":99,"slug":24,"hasResults":100,"nctId":101,"briefTitle":102,"officialTitle":102,"acronym":24,"eligibilityCriteria":103,"healthyVolunteers":104,"sex":105,"minAge":106,"maxAge":107,"enrollmentInfo":108,"targetDuration":24,"studyType":111,"phases":112,"briefSummary":114,"conditions":115,"keywords":118,"overallStatus":80,"whyStopped":24,"lastUpdateSubmitDate":127,"lastUpdatePostDateStruct":128,"startDateStruct":131,"completionDateStruct":133,"leadSponsor":135,"locationsCount":136},{"fullName":5,"class":6},"University of Central Florida","OTHER",{"primaryOutcomes":8,"secondaryOutcomes":15,"otherOutcomes":24},[9,13],{"measure":10,"description":11,"timeFrame":12},"Motor Unit Recruitment (amplitude relative to recruitment threshold)","Measured via surface EMG decomposition","Baseline, 0, 30, and 60 minutes post-intervention",{"measure":14,"description":11,"timeFrame":12},"Motor Unit Recruitment (firing rate relative to recruitment threshold)",[16,20],{"measure":17,"description":18,"timeFrame":19},"Quadriceps Inhibition (Hoffmann Reflex)","Measured with femoral nerve stimulation","Baseline, 0 and 60 minutes post-intervention",{"measure":21,"description":22,"timeFrame":23},"Isometric Peak Torque (Quadriceps Strength)","Measured with isokinetic dynamometer (Biodex)","Baseline and 60 minutes post-intervention",null,{"allocation":26,"interventionModel":27,"interventionModelDescription":28,"primaryPurpose":29,"observationalModel":24,"timePerspective":24,"maskingInfo":30},"RANDOMIZED","PARALLEL","Parallel Assignment","BASIC_SCIENCE",{"masking":31,"maskingDescription":24,"whoMasked":32},"SINGLE",[33],"PARTICIPANT","Using a controlled laboratory model, the investigators will simulate knee injury through two methods: (1) intra-articular saline injection to induce effusion, and (2) intra-articular lidocaine injection to induce sensory deafferentation. Healthy participants aged 18-30 will undergo surface and decomposition EMG, isometric strength testing, and reflex measurements before and after the intervention. The primary outcome is motor unit recruitment characteristics, with secondary outcomes including quadriceps inhibition (Hoffmann reflex) and isometric peak torque. The findings will inform future neuromodulatory approaches in rehabilitation.",[36,42,48],{"label":37,"type":38,"description":39,"interventionNames":40},"Effusion Group","EXPERIMENTAL","60 mL sterile saline injected into knee",[41],"Device: Joint Effusion via 60 mL Sterile Saline",{"label":43,"type":44,"description":45,"interventionNames":46},"Deafferentation Group","ACTIVE_COMPARATOR","Lidocaine (single intra-articular dose)",[47],"Drug: Intra-articular Lidocaine",{"label":49,"type":50,"description":51,"interventionNames":52},"Control Group","SHAM_COMPARATOR","Sham procedure with fake needle",[53],"Other: Sham injection",[55,60,65],{"type":56,"name":57,"description":58,"armGroupLabels":59,"otherNames":24},"DEVICE","Joint Effusion via 60 mL Sterile Saline","Injection of sterile saline into the knee joint to simulate joint swelling and induce quadriceps inhibition.",[37],{"type":61,"name":62,"description":63,"armGroupLabels":64,"otherNames":24},"DRUG","Intra-articular Lidocaine","Injection of 7 mL lidocaine into the knee joint to simulate deafferentation by temporarily blocking sensory input.",[43],{"type":6,"name":66,"description":67,"armGroupLabels":68,"otherNames":24},"Sham injection","Simulated knee injection using a stage needle without skin penetration, used to blind participants and serve as control.",[49],[70,75],{"name":71,"role":72,"phone":73,"phoneExt":24,"email":74},"Grant Norte, Ph.D.","CONTACT","407-823-3188","Grant.Norte@ucf.edu",{"name":76,"role":72,"phone":24,"phoneExt":24,"email":77},"Meredith Chaput, Ph.D.","Meredith.Chaput@ucf.edu",[79],{"facility":5,"status":80,"city":81,"state":82,"zip":83,"country":84,"countryCode":85,"cosmosGeoPoint":86,"geoPoint":91,"contacts":92},"RECRUITING","Orlando","Florida","32816","United States","US",{"type":87,"coordinates":88},"Point",[89,90],-81.37924,28.53834,{"lat":90,"lon":89},[93],{"name":94,"role":72,"phone":73,"phoneExt":24,"email":74},"Grant E. Norte",{"type":96,"investigatorFullName":97,"investigatorTitle":98,"investigatorAffiliation":5,"oldNameTitle":24,"oldOrganization":24},"PRINCIPAL_INVESTIGATOR","Grant Norte","Associate Professor","100592870",false,"NCT06999057","Quadriceps Motor Unit Adaptation to Simulated Knee Injury","Inclusion Criteria:\n\n1. Age 18-30 years\n2. Physically active (Tegner ≥ 5)\n3. No prior lower-limb surgery or major injury\n\nExclusion Criteria:\n\n1. Lower limb surgery or significant injury in past 2 years\n2. Cardiopulmonary, neurological, or psychiatric disorders\n3. Needle\u002Felectrical stimulation anxiety\n4. Medications affecting neuromuscular or psychological function\n5. Pregnancy\n6. Allergic to lidocaine\n7. Inability to elicit Hoffmann reflex",true,"ALL","18 Years","30 Years",{"count":109,"type":110},45,"ESTIMATED","INTERVENTIONAL",[113],"EARLY_PHASE1","This study investigates how simulated knee injury-via artificial joint effusion or deafferentation-affects quadriceps motor unit behavior in healthy young adults. Participants will complete neuromuscular testing during a single 2-hour lab session. This research seeks to improve understanding of muscle inhibition and inform interventions after real-world knee trauma.",[116,117],"Muscle Inhibition","Knee Injury Simulation",[119,120,121,122,123,124,125,126],"Quadriceps","Electromyography","Motor Unit","Knee Effusion","Lidocaine","Deafferentation","Neuromuscular Adaptation","Muscle Strength","2026-04-27",{"date":129,"type":130},"2026-05-01","ACTUAL",{"date":132,"type":110},"2026-08-01",{"date":134,"type":110},"2027-08-01",{"name":5,"class":6},1]