[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100456147":3},{"organization":4,"armGroups":7,"interventions":16,"overallOfficials":35,"centralContacts":39,"locations":45,"responsibleParty":63,"collaborators":22,"id":66,"slug":22,"hasResults":67,"nctId":68,"briefTitle":69,"officialTitle":69,"acronym":22,"eligibilityCriteria":70,"healthyVolunteers":71,"sex":72,"minAge":73,"maxAge":74,"enrollmentInfo":75,"targetDuration":22,"studyType":78,"phases":79,"briefSummary":81,"conditions":82,"keywords":22,"overallStatus":48,"whyStopped":22,"lastUpdateSubmitDate":86,"lastUpdatePostDateStruct":87,"startDateStruct":90,"completionDateStruct":92,"leadSponsor":94,"locationsCount":95},{"fullName":5,"class":6},"University of Missouri-Columbia","OTHER",[8],{"label":9,"type":6,"description":10,"interventionNames":11},"Hypoxia Exposure","Men and women will be exposed to isocapnic hypoxia. Participants will wear a mask and systemic oxygen levels will be titrated to attain hypoxemia as assessed by pulse oximetry.",[12,13,14,15],"Drug: Propranolol Hydrochloride","Drug: Isoproterenol","Drug: Phentolamine Mesylate","Drug: Norepinephrine",[17,23,27,31],{"type":18,"name":19,"description":20,"armGroupLabels":21,"otherNames":22},"DRUG","Propranolol Hydrochloride","Regional forearm blockade of β-adrenergic receptors at 20 mcg\u002FdL\u002Fmin via brachial artery catheter during normoxia and hypoxia exposures",[9],null,{"type":18,"name":24,"description":25,"armGroupLabels":26,"otherNames":22},"Isoproterenol","Dose response (1, 3, 6, and 12 ng\u002FdL\u002Fmin) regional infusion to assess β-adrenergic receptor responsiveness",[9],{"type":18,"name":28,"description":29,"armGroupLabels":30,"otherNames":22},"Phentolamine Mesylate","This infusion will be for 10 min before baseline measurement (12 mcg\u002FdL\u002Fmin) and continue the infusion at a maintenance rate (5 mcg\u002FdL\u002Fmin).",[9],{"type":18,"name":32,"description":33,"armGroupLabels":34,"otherNames":22},"Norepinephrine","Regional forearm infusion at 8 ng\u002FdL\u002Fmin via brachial artery catheter during normoxia and hypoxia exposures",[9],[36],{"name":37,"affiliation":5,"role":38},"Jacqueline Limberg, Ph.D.","PRINCIPAL_INVESTIGATOR",[40],{"name":41,"role":42,"phone":43,"phoneExt":22,"email":44},"Jacqueline K Limberg, Ph.D.","CONTACT","5738822544","limbergj@missouri.edu",[46],{"facility":47,"status":48,"city":49,"state":50,"zip":51,"country":52,"cosmosGeoPoint":53,"geoPoint":58,"contacts":59},"University of Missouri","RECRUITING","Columbia","Missouri","65211","United States",{"type":54,"coordinates":55},"Point",[56,57],-92.33407,38.95171,{"lat":57,"lon":56},[60],{"name":61,"role":42,"phone":43,"phoneExt":22,"email":62},"Jennifer L Harper","harperjl@missouri.edu",{"type":38,"investigatorFullName":64,"investigatorTitle":65,"investigatorAffiliation":5,"oldNameTitle":22,"oldOrganization":22},"Jacqueline K Limberg, PhD","Assistant Professor","100456147",false,"NCT05219799","Sex Disparities in Hypoxic Vasodilation and Impact of Obesity","Inclusion Criteria:\n\n* BMI \\>18 kg\u002Fm2\n\nExclusion Criteria:\n\n* Pregnancy, breastfeeding\n* Diagnosed sleep apnea or AHI \\>10 events\u002Fhr\n* Current smoking\u002FNicotine use\n* Increased risk of bleeding, pro-coagulant disorders, clotting disorders, anticoagulation therapy\n* Nerve\u002Fneurologic disease\n* Cardiovascular, hepatic, renal, respiratory disease\n* Blood pressure ≥140\u002F90 mmHg\n* Diabetes, Polycystic ovarian syndrome\n* Communication barriers\n* Prescription medications, Sensitivity to lidocaine",true,"ALL","18 Years","45 Years",{"count":76,"type":77},72,"ESTIMATED","INTERVENTIONAL",[80],"EARLY_PHASE1","The purpose of this project is to examine key mechanisms contributing to sex-differences in hypoxic vasodilation and the impact of obesity, with particular emphasis on the sympathetic nervous system.",[83,84,85],"Obesity","Vasodilation","Healthy","2025-05-22",{"date":88,"type":89},"2025-05-29","ACTUAL",{"date":91,"type":89},"2023-03-14",{"date":93,"type":77},"2026-06-30",{"name":5,"class":6},1]