[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100364556":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":33,"centralContacts":37,"locations":42,"responsibleParty":61,"collaborators":63,"id":67,"slug":32,"hasResults":68,"nctId":69,"briefTitle":70,"officialTitle":70,"acronym":71,"eligibilityCriteria":72,"healthyVolunteers":73,"sex":74,"minAge":75,"maxAge":76,"enrollmentInfo":77,"targetDuration":32,"studyType":80,"phases":81,"briefSummary":83,"conditions":84,"keywords":87,"overallStatus":44,"whyStopped":32,"lastUpdateSubmitDate":91,"lastUpdatePostDateStruct":92,"startDateStruct":95,"completionDateStruct":97,"leadSponsor":99,"locationsCount":100},{"fullName":5,"class":6},"Wake Forest University Health Sciences","OTHER",[8,15],{"label":9,"type":10,"description":11,"interventionNames":12},"Preterm Group","EXPERIMENTAL","Subjects with very low birth weight (\\\u003C37 completed weeks' gestation and birth weight \\\u003C1500 g) will receive a dietary intervention (high\u002Flow salt diet) and FDA approved drug, Allopurinol",[13,14],"Drug: Allopurinol","Other: Dietary Intervention",{"label":16,"type":17,"description":18,"interventionNames":19},"Term-born control group","ACTIVE_COMPARATOR","Subjects with birth weight ≥2500 g will receive a dietary intervention (high\u002Flow salt diet)",[14],[21,28],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"DRUG","Allopurinol","Study Part 2- Preterm group only: After Visit 5 preterm born participants will start allopurinol 200 mg daily PO for 6 weeks. The 1 week high and low salt diets and assessments will be repeated while on allopurinol.",[9],[27],"Zyloprim",{"type":6,"name":29,"description":30,"armGroupLabels":31,"otherNames":32},"Dietary Intervention","High-Na+ (250 mmol\u002Fd) and low-Na+ (50 mmol\u002Fd) standard isocaloric K+ diets (75 mmol\u002F1000 kcal\u002Fd) for 1 week each as 3 meals and 1 snack a day provided by the Clinical Research Unit Metabolic Kitchen. Part 2 preterm only- the diets will be repeated while the participant is taking allopurinol.",[9,16],null,[34],{"name":35,"affiliation":5,"role":36},"Hossam Shaltout, PhD","PRINCIPAL_INVESTIGATOR",[38],{"name":35,"role":39,"phone":40,"phoneExt":32,"email":41},"CONTACT","336-716-1251","Hossam.Shaltout@advocatehealth.org",[43],{"facility":5,"status":44,"city":45,"state":46,"zip":47,"country":48,"cosmosGeoPoint":49,"geoPoint":54,"contacts":55},"RECRUITING","Winston-Salem","North Carolina","27157","United States",{"type":50,"coordinates":51},"Point",[52,53],-80.24422,36.09986,{"lat":53,"lon":52},[56,57,58],{"name":35,"role":39,"phone":40,"phoneExt":32,"email":41},{"name":35,"role":36,"phone":32,"phoneExt":32,"email":32},{"name":59,"role":60,"phone":32,"phoneExt":32,"email":32},"Andrew South, MD, MS","SUB_INVESTIGATOR",{"type":62,"investigatorFullName":32,"investigatorTitle":32,"investigatorAffiliation":32,"oldNameTitle":32,"oldOrganization":32},"SPONSOR",[64],{"name":65,"class":66},"National Heart, Lung, and Blood Institute (NHLBI)","NIH","100364556",false,"NCT04026776","Uric Acid, Klotho and Salt Sensitivity in Young Adults Born Preterm","PEPC3","Inclusion Criteria:\n\n* Singleton birth\n* Born at less than 34 weeks gestational age (preterm cohort)\n* Born at greater than 36 weeks gestational age (term cohort)\n\nExclusion Criteria:\n\n* Twin birth\n* Congenital anomalies or genetic syndromes\n* Currently pregnant or breast feeding\n* Subject-reported history of hypertension\n* Current use of antihypertensive medications\n* Active cancer\n* Chronic kidney disease\n* Heart failure\n* Liver failure",true,"ALL","22 Years","33 Years",{"count":78,"type":79},120,"ESTIMATED","INTERVENTIONAL",[82],"EARLY_PHASE1","The purpose of this research is to learn about how salt in the diet influences blood pressure in young adults who were born prematurely.",[85,86],"Salt; Excess","Blood Pressure Disorders",[88,89,90],"Uric Acid sensitivity","Salt sensitivity","Blood Pressure Influences","2026-06-26",{"date":93,"type":94},"2026-06-29","ACTUAL",{"date":96,"type":94},"2020-09-02",{"date":98,"type":79},"2026-12",{"name":5,"class":6},1]