[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100549576":3},{"organization":4,"outcomesModule":7,"designInfo":28,"detailedDescription":36,"studyPopulation":27,"armGroups":37,"interventions":52,"overallOfficials":57,"centralContacts":61,"locations":66,"responsibleParty":100,"collaborators":102,"id":106,"slug":27,"hasResults":107,"nctId":108,"briefTitle":109,"officialTitle":110,"acronym":27,"eligibilityCriteria":111,"healthyVolunteers":112,"sex":113,"minAge":114,"maxAge":27,"enrollmentInfo":115,"targetDuration":27,"studyType":118,"phases":119,"briefSummary":121,"conditions":122,"keywords":27,"overallStatus":87,"whyStopped":27,"lastUpdateSubmitDate":124,"lastUpdatePostDateStruct":125,"startDateStruct":128,"completionDateStruct":130,"leadSponsor":132,"locationsCount":133},{"fullName":5,"class":6},"Northeastern University","OTHER",{"primaryOutcomes":8,"secondaryOutcomes":17,"otherOutcomes":27},[9,13],{"measure":10,"description":11,"timeFrame":12},"Knowledge","A multiple-item knowledge test designed to test comprehension of the patient education document","Baseline and 30 minutes",{"measure":14,"description":15,"timeFrame":16},"State Anxiety scale from State-Trait Anxiety Inventory","Self-report state anxiety scale from the State-Trait Anxiety Inventory. 20 items, 4-point Likert scale. A higher score indicates more severe anxiety with a potential range from 20 to 80.","30 minutes",[18,21,24],{"measure":19,"description":20,"timeFrame":16},"Satisfaction with illustration","Likert items to assess satisfaction with the document and illustration",{"measure":22,"description":23,"timeFrame":16},"Reading Effort","Likert items to assess perceived effort in reading a document and illustration",{"measure":25,"description":26,"timeFrame":16},"Acceptability","Likert items to assess acceptability and appropriateness of the illustration",null,{"allocation":29,"interventionModel":30,"interventionModelDescription":31,"primaryPurpose":6,"observationalModel":27,"timePerspective":27,"maskingInfo":32},"RANDOMIZED","PARALLEL","3-treatment between-subjects randomized experiment",{"masking":33,"maskingDescription":27,"whoMasked":34},"SINGLE",[35],"PARTICIPANT","The investigators are developing a new approach to explaining patient education documents and illustrations to patients with varying levels of health literacy, involving the use of Embodied Conversational Agents (ECAs). The investigators will evaluate our ECA-augmented Document Explanation tool to determine whether it improves patient learning relative to traditional static patient education documents. The investigators will conduct a 3-arm randomized between-subjects experiment, in which participants read a patient education document with embedded medical illustration, either unaided (CONTROL), with the assistance of an ECA rendered in 2D on a standard computer monitor (ECA-2D), or with the assistance of an ECA in immersive Virtual Reality (ECA-3D).",[38,44,48],{"label":39,"type":40,"description":41,"interventionNames":42},"ECA-2D","EXPERIMENTAL","Participants read a patient education document with the assistance of an embodied conversational agent rendered in 2D on a computer monitor.",[43],"Other: Embodied Conversational Agent (ECA)",{"label":45,"type":40,"description":46,"interventionNames":47},"ECA-3D","Participants read a patient education document with the assistance of an embodied conversational agent in virtual reality.",[43],{"label":49,"type":50,"description":51,"interventionNames":27},"CONTROL","NO_INTERVENTION","Participants read a patient education document without assistance.",[53],{"type":6,"name":54,"description":55,"armGroupLabels":56,"otherNames":27},"Embodied Conversational Agent (ECA)","A computer-animated character that can explain a medical illustration to laypersons.",[39,45],[58],{"name":59,"affiliation":5,"role":60},"Timothy Bickmore, PhD","PRINCIPAL_INVESTIGATOR",[62],{"name":59,"role":63,"phone":64,"phoneExt":27,"email":65},"CONTACT","6173735477","t.bickmore@northeastern.edu",[67,86],{"facility":68,"status":69,"city":70,"state":71,"zip":72,"country":73,"countryCode":74,"cosmosGeoPoint":75,"geoPoint":80,"contacts":81},"Tufts Medical Center","NOT_YET_RECRUITING","Boston","Massachusetts","02111","United States","US",{"type":76,"coordinates":77},"Point",[78,79],-71.05977,42.35843,{"lat":79,"lon":78},[82],{"name":83,"role":63,"phone":84,"phoneExt":27,"email":85},"Cameron Neeson","617-636-5747","cameron.neeson@tuftsmedicalcenter.org",{"facility":5,"status":87,"city":70,"state":71,"zip":88,"country":73,"countryCode":74,"cosmosGeoPoint":89,"geoPoint":91,"contacts":92},"RECRUITING","02115",{"type":76,"coordinates":90},[78,79],{"lat":79,"lon":78},[93,97],{"name":94,"role":63,"phone":95,"phoneExt":27,"email":96},"Madison Blain","617-858-6727","m.blain@northeastern.edu",{"name":98,"role":63,"phone":99,"phoneExt":27,"email":65},"Tim Bickmore, PhD","617-373-5477",{"type":101,"investigatorFullName":27,"investigatorTitle":27,"investigatorAffiliation":27,"oldNameTitle":27,"oldOrganization":27},"SPONSOR",[103,104],{"name":68,"class":6},{"name":105,"class":6},"Boston University","100549576",false,"NCT06435819","ECA-enhanced Document Explanation RCT","Advancing Medical Illustration in Patient Education Materials: From Art to Science. Study 2: ECA-enhanced Document Explanation RCT","Inclusion Criteria:\n\n* Over 18 years old\n* Speaks English or Spanish fluently\n* Is able to independently consent\n* Has adequate corrected vision to read patient education documents\n\nExclusion Criteria:\n\n\\* None",true,"ALL","18 Years",{"count":116,"type":117},300,"ESTIMATED","INTERVENTIONAL",[120],"NA","The investigators will evaluate a computer-animated character that explains medical illustrations to people, comparing the character to having people understand the illustrations on their own, and also comparing the computer character on a computer display to one in immersive virtual reality. The investigators will determine which method leads to the best understanding and lowest anxiety.",[123],"Healthy","2025-09-29",{"date":126,"type":127},"2025-10-03","ACTUAL",{"date":129,"type":127},"2025-09-05",{"date":131,"type":117},"2027-09-01",{"name":5,"class":6},2]