Health Trials

About this trial

This study aims to investigate the effect of a low-calorie diet rich in medium-chain triglycerides (MCTs) based on traditional Minangkabau foods on metabolic biomarkers in individuals with obesity. The traditional Minangkabau foods used in this study consist primarily of coconut milk-based dishes, which contain coconut oil as a natural source of MCTs. The metabolic biomarkers assessed include body mass index (BMI), waist circumference, systolic and diastolic blood pressure, body fat percentage, fasting blood glucose levels, lipid profile, leptin concentrations, and DNA methylation of the leptin gene promoter. Based on these metabolic biomarker measurements, participants will be classified into metabolic obesity phenotypes, namely metabolically healthy obesity (MHO) and metabolically unhealthy obesity (MUHO). The researchers hypothesize that the provision of a low-calorie, MCT-rich diet based on traditional Minangkabau foods will have a significant effect on metabolic biomarkers and metabolic status in individuals with obesity.

Eligibility criteria

Qualifiers

Administrative staff of the Faculty of Medicine and the Faculty of Public Health, Andalas University, Padang, with obesity defined as a body mass index (BMI) ≥ 25 kg/m².

Willing to participate in the study by providing written informed consent.

Participants with obesity classified as Metabolically Unhealthy Obese (MUHO)

Disqualifiers

Did not come and could not be found at the time of research data collection

Unable to follow the dietary arrangements as set

Taking anti-diabetic or anti-lipid drugs

Use of contraceptives or hormonal drugs

Trial design

Treatments tested in this trial

  • Low-Calorie Diet Rich in Medium-Chain Triglycerides (MCTs) Based on Traditional Minangkabau Foods

Treatment groups

40 Participants
are divided into 2 treatment groups

Locations

1
Prof. Nur Indrawaty Lipoeto PadangWest Sumatera, Indonesia

Sponsors and collaborators

Andalas University

Lead sponsor

Source ClinicalTrials.gov