[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100643743":3},{"organization":4,"armGroups":7,"interventions":16,"overallOfficials":31,"centralContacts":35,"locations":22,"responsibleParty":44,"collaborators":22,"id":47,"slug":22,"hasResults":48,"nctId":49,"briefTitle":50,"officialTitle":51,"acronym":22,"eligibilityCriteria":52,"healthyVolunteers":48,"sex":53,"minAge":54,"maxAge":55,"enrollmentInfo":56,"targetDuration":22,"studyType":59,"phases":60,"briefSummary":62,"conditions":63,"keywords":22,"overallStatus":66,"whyStopped":22,"lastUpdateSubmitDate":67,"lastUpdatePostDateStruct":68,"startDateStruct":71,"completionDateStruct":73,"leadSponsor":75,"locationsCount":22},{"fullName":5,"class":6},"Samsung Medical Center","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"Experimental group","EXPERIMENTAL","During one-lung ventilation, baseline intrinsic PEEP and stroke volume will be measured. All participants will receive three PEEP interventions: 0 cmH2O, 5 cmH2O, and 70% of the intrinsic PEEP value. The order of interventions is randomized. Each intervention will be maintained for 5 minutes, with a 5-minute washout period between interventions to minimize mutual interference. At the end of each intervention, two primary outcomes (intrinsic PEEP and stroke volume) will be measured.",[13,14,15],"Procedure: PEEP0","Procedure: PEEP5","Procedure: PEEPi",[17,23,27],{"type":18,"name":19,"description":20,"armGroupLabels":21,"otherNames":22},"PROCEDURE","PEEP0","PEEP 0 (zero) means off-PEEP on the anesthesia machine.",[9],null,{"type":18,"name":24,"description":25,"armGroupLabels":26,"otherNames":22},"PEEP5","PEEP5 means setting the PEEP to 5 cmH2O on the anesthesia machine.",[9],{"type":18,"name":28,"description":29,"armGroupLabels":30,"otherNames":22},"PEEPi","PEEPi (individualized PEEP) means setting the PEEP to 70% of intrinsic PEEP on the anesthesia machine.",[9],[32],{"name":33,"affiliation":5,"role":34},"Hyun Joo Ahn, MD, PhD","PRINCIPAL_INVESTIGATOR",[36,40],{"name":33,"role":37,"phone":38,"phoneExt":22,"email":39},"CONTACT","+82234100784","hyunjooahn@skku.edu",{"name":41,"role":37,"phone":42,"phoneExt":22,"email":43},"Heejoon Jeong, MD","+82234100841","heejoonjeong@skku.edu",{"type":34,"investigatorFullName":45,"investigatorTitle":46,"investigatorAffiliation":5,"oldNameTitle":22,"oldOrganization":22},"Hyun Joo Ahn","Anesthesiologist, Professor","100643743",false,"NCT07638176","Effect of Individualized Positive End-expiratory Pressure (PEEP) in Patients Who Have an Intrinsic PEEP During One-lung Ventilation","Effects of Individualized Positive End-expiratory Pressure (PEEP) on Intrinsic PEEP and Stroke Volume During One-lung Ventilation: a Single-center, Randomized Crossover Study","Inclusion Criteria:\n\n* American Society of Anesthesiologists Physical Status I - III\n* The Eastern Cooperative Oncology Group Performance Status Grade 0 - 2\n* Lung resection surgery requiring one-lung ventilation for over 60 minutes\n* Indication of double-lumen endobronchial tube (female 35 Fr, male 37 Fr)\n* Patient who is diagnosed with intrinsic PEEP during one-lung ventilation\n\nExclusion Criteria:\n\n* Large bullae\n* Emergency surgery\n* Mechanical ventilation before surgery\n* Hemodynamic instability before surgery\n* Surgery requiring cardiopulmonary bypass\n* Pregnancy, breastfeeding patient\n* Patient's refusal to participate\n* No intrinsic PEEP during one-lung ventilation","ALL","19 Years","100 Years",{"count":57,"type":58},48,"ESTIMATED","INTERVENTIONAL",[61],"NA","This study investigates the effects of three extrinsic PEEP settings-5 cmH2O, 0 cmH2O, and an individualized PEEP (70% of the measured intrinsic PEEP)-on intrinsic PEEP and hemodynamic stability in patients with intrinsic PEEP undergoing lung resection surgery, using a randomized, crossover design.",[64,65],"Pulmonary Disease (COPD), Chronic Obstructive","Lung Resection Surgery","NOT_YET_RECRUITING","2026-06-04",{"date":69,"type":70},"2026-06-10","ACTUAL",{"date":72,"type":58},"2026-06-01",{"date":74,"type":58},"2027-05-31",{"name":5,"class":6}]