[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100617413":3},{"organization":4,"outcomesModule":7,"designInfo":23,"detailedDescription":34,"studyPopulation":17,"armGroups":35,"interventions":48,"overallOfficials":58,"centralContacts":62,"locations":68,"responsibleParty":87,"collaborators":17,"id":89,"slug":17,"hasResults":90,"nctId":91,"briefTitle":92,"officialTitle":92,"acronym":17,"eligibilityCriteria":93,"healthyVolunteers":94,"sex":95,"minAge":96,"maxAge":97,"enrollmentInfo":98,"targetDuration":17,"studyType":101,"phases":102,"briefSummary":104,"conditions":105,"keywords":107,"overallStatus":71,"whyStopped":17,"lastUpdateSubmitDate":109,"lastUpdatePostDateStruct":110,"startDateStruct":113,"completionDateStruct":115,"leadSponsor":117,"locationsCount":118},{"fullName":5,"class":6},"Jordan University of Science and Technology","OTHER",{"primaryOutcomes":8,"secondaryOutcomes":17,"otherOutcomes":18},[9,13],{"measure":10,"description":11,"timeFrame":12},"Postoperative Pain Intensity","Postoperative pain intensity will be assessed using a visual analogue scale (VAS) ranging from 1 (no pain) to 10 (worst pain imaginable). Participants will record pain scores at standardized time points following mandibular third molar extraction.","12 hours (postoperative day 1), postoperative day 3, and postoperative day 7. Units of measure is VAS score (1-10).",{"measure":14,"description":15,"timeFrame":16},"Alveolar Socket Bone Healing","Alveolar socket bone healing will be evaluated histologically by quantifying the percentage of woven bone formation within the extraction socket. Core biopsies will be obtained six weeks post-extraction and analyzed using digital histomorphometry. The percentage of woven bone area within predefined regions of interest will be calculated using ImageJ software.","6 weeks after tooth extraction. units of measure is percentage of woven bone area (%)",null,[19],{"measure":20,"description":21,"timeFrame":22},"Radiographic Assessment of Socket Healing","Radiographic socket healing will be assessed descriptively using orthopantomogram (OPG) imaging. Standardized radiographs will be obtained preoperatively and approximately six to eight weeks post-extraction to evaluate changes in socket radiodensity.","Preoperative baseline and 6-8 weeks post-extraction",{"allocation":24,"interventionModel":25,"interventionModelDescription":26,"primaryPurpose":27,"observationalModel":17,"timePerspective":17,"maskingInfo":28},"RANDOMIZED","CROSSOVER","application of Hyaluronic acid","TREATMENT",{"masking":29,"maskingDescription":30,"whoMasked":31},"DOUBLE","Double (Participant, Investigator)",[32,33],"PARTICIPANT","INVESTIGATOR","This study is designed as a prospective, randomized, controlled clinical trial with a split-mouth design to assess the effect of topical hyaluronic acid on postoperative pain and alveolar socket bone healing following surgical extraction of mandibular third molars. The study will be conducted at the Oral and Maxillofacial Surgery and Preventive Dentistry clinics, Faculty of Dentistry, Jordan University of Science and Technology, Irbid, Jordan.\n\nA total of 20 patients requiring bilateral surgical extraction of mandibular third molars will be enrolled. All participants will receive verbal and written information regarding the study procedures, and written informed consent will be obtained prior to participation. Randomization will be performed using a closed-envelope method. In each patient, one extraction site will be randomly allocated to receive hyaluronic acid gel combined with a collagen sponge (test site), while the contralateral site will receive a collagen sponge alone (control site).\n\nThe hyaluronic acid used in this study is a low-molecular weight sodium hyaluronate gel (Hyadent®, BioScience GmbH, Ransbach-Baumbach, Germany), supplied in sterile 1 mL syringes with blunt angulated cannulas. Each syringe contains sodium hyaluronate (14.0 mg), sodium chloride (6.9 mg), and water for injection. The formulation has modified viscosity and a short resorption time, allowing rapid absorption by the surrounding tissues.\n\nAll surgical procedures will be performed by a single experienced oral surgeon under standardized conditions. Preoperative evaluation includes medical and dental history, clinical examination, and panoramic radiography. Local anesthesia will be administered using an inferior alveolar nerve block with buccal infiltration of 2% lidocaine with 1:100,000 epinephrine. A standardized mucoperiosteal envelope flap will be raised for all procedures. Bone removal and tooth sectioning will be carried out when necessary using a low-speed handpiece under copious sterile saline irrigation.\n\nAfter tooth removal, hyaluronic acid gel will be placed into the extraction socket at the test site and covered with a collagen sponge. Control sites will receive a collagen sponge alone. Primary closure will be achieved using 3-0 silk sutures. All patients will receive standardized postoperative instructions and medications. Sutures will be removed on postoperative day seven.\n\nPostoperative pain will be assessed using a visual analogue scale (VAS) ranging from 1 (no pain) to 10 (worst pain imaginable). Participants will record pain scores at standardized time points: 12 hours after surgery (postoperative day 1), postoperative day 3, and postoperative day 7.\n\nRadiographic assessment of socket healing will be performed using orthopantomogram (OPG) imaging in a randomly selected subgroup of participants approximately eight weeks after extraction. Radiographs will be obtained using standardized exposure parameters and processed under controlled conditions to ensure consistency.\n\nHistological evaluation of socket healing will be conducted six weeks after extraction. Core biopsies will be obtained from both extraction sites under local anesthesia without flap reflection using a 3 mm diameter graded trephine bur. Harvested specimens will be fixed in formalin, decalcified, processed, and stained with hematoxylin and eosin. Digital images will be analyzed using image analysis software to calculate the percentage of woven bone within predefined regions of interest.\n\nStatistical analysis will be performed using Statistical Package for the Social Sciences (SPSS) software. Descriptive statistics will be calculated for all variables. Comparative analyses will be conducted to evaluate differences in postoperative pain and woven bone formation between test and control sites, as well as changes in pain intensity over time.",[36,43],{"label":37,"type":38,"description":39,"interventionNames":40},"placebo extraction side","PLACEBO_COMPARATOR","Surgical extraction of wisdom tooth with placebo administration inside the extraction site using collagen sponge",[41,42],"Procedure: Surgical extraction of wisdom teeth","Procedure: bone biobsy",{"label":44,"type":45,"description":46,"interventionNames":47},"experimental extraction side","EXPERIMENTAL","Surgical extraction of wisdom tooth with placebo administration inside the extraction site using hyaluronic acid gel",[41,42],[49,54],{"type":50,"name":51,"description":52,"armGroupLabels":53,"otherNames":17},"PROCEDURE","Surgical extraction of wisdom teeth","A standardized surgical procedure was performed by a single experienced surgeon (ZA). Under strict aseptic conditions, an inferior alveolar nerve block with buccal infiltration, was given using lidocaine HCl 2% with epinephrine 1:100,000 (Cook-Waite, Rochester, NY). A mucoperiosteal envelope flap was utilized for all surgeries. Bone removal and tooth sectioning were performed as deemed necessary using a low-speed handpiece under copious saline irrigation. After tooth removal, HA gel (Hyadent) was placed inside the extraction socket and covered with collagen sponge in the test sockets, while only coverage with collagen sponge was placed in the control sockets. Subsequently, flap closure was achieved using 3-0 silk sutures",[44,37],{"type":50,"name":55,"description":56,"armGroupLabels":57,"otherNames":17},"bone biobsy","After 6 weeks, core biopsies are taken from both sides. Under local anesthesia, the core biopsies sre taken without reflection of a flap, using a graded trephine bur (MCT, Korea) of 3 mm diameter (which is not invasive or having any complication) for later histological evaluation. Specimens harvested from each patient are fixed in 10% formalin, then decalcified using 10% hydrochloric acid. After processing, 5 micrometer sections are prepared and stained with hematoxylin and eosin stain (H\\&E).\n\nDigital images are acquired from each section at a magnification of × 40. ImageJ 1.52a software (National Institute of Health, Bethesda, Maryland, USA) is used to calculate the percentage of woven bone area within selected regions of interest (ROI) in each image, utilizing the color thresholding feature. To ensure that measurements are valid, 3 measurements are made for each of the hard tissue and soft tissue components, and for the total area of the ROI in pixels.",[44,37],[59],{"name":60,"affiliation":5,"role":61},"Rola Habashneh, Professor","STUDY_CHAIR",[63],{"name":64,"role":65,"phone":66,"phoneExt":17,"email":67},"Tamimi","CONTACT","00962795036670","zztamimi@just.edu.jo",[69],{"facility":70,"status":71,"city":72,"state":17,"zip":73,"country":74,"countryCode":75,"cosmosGeoPoint":76,"geoPoint":81,"contacts":82},"Higher specialty training center","RECRUITING","Irbid","11196","Jordan","JO",{"type":77,"coordinates":78},"Point",[79,80],35.85,32.55556,{"lat":80,"lon":79},[83],{"name":84,"role":65,"phone":85,"phoneExt":17,"email":86},"rola Habashneh, Professor","0096227201000","raalhabashneh@just.edu.jo",{"type":88,"investigatorFullName":17,"investigatorTitle":17,"investigatorAffiliation":17,"oldNameTitle":17,"oldOrganization":17},"SPONSOR","100617413",false,"NCT07318298","Effect of Injectable Hyaluronic Acid (HYADENT BG (HA)) on Bone Healing in Extraction Sockets","Inclusion Criteria:\n\nMale and female participants aged 18 to 35 years\n\nPresence of bilateral impacted mandibular third molars classified as Pell and Gregory Class II, Position B\n\nClassified as American Society of Anesthesiologists (ASA) Physical Status I\n\nAbsence of active local infection at the surgical site (e.g., no swelling, trismus, hyperthermia)\n\nAbility to maintain adequate oral hygiene\n\nAbility to understand and provide written informed consent\n\nAbility to read and understand Arabic or English\n\nWillingness to comply with study procedures and follow-up visits\n\nExclusion Criteria:\n\nHistory of systemic diseases such as diabetes mellitus, hypertension, gastric ulcer, or other significant medical conditions\n\nPresence of severe or chronic illness requiring frequent hospitalization\n\nPregnant or breastfeeding individuals\n\nHistory of cognitive or motor impairment that may interfere with study participation\n\nUse of anti-inflammatory or analgesic medications within two weeks before surgery\n\nKnown allergy or hypersensitivity to nonsteroidal anti-inflammatory drugs (NSAIDs)\n\nCurrent smoker\n\nUse of anticoagulant therapy\n\nAny condition that, in the investigator's judgment, may interfere with healing or study outcomes",true,"ALL","18 Years","35 Years",{"count":99,"type":100},20,"ESTIMATED","INTERVENTIONAL",[103],"NA","Complications such as postoperative pain and delayed socket healing are relatively common following surgical extraction of mandibular third molars. Various biomaterials have been investigated to enhance wound healing and reduce postoperative morbidity. Hyaluronic acid (HA) has demonstrated anti-inflammatory and regenerative properties that may improve both soft and hard tissue healing.\n\nThe aim of this study is to evaluate the effect of topical hyaluronic acid on postoperative pain and alveolar socket bone healing following surgical extraction of mandibular third molars. A prospective, randomized, controlled clinical trial with a split-mouth design will be conducted. Twenty patients requiring bilateral mandibular third molar surgical extraction will be enrolled. In each patient, one extraction socket will receive hyaluronic acid combined with a collagen sponge, while the contralateral socket will receive a collagen sponge alone, according to random allocation. Postoperative pain will be assessed using a visual analogue scale, and socket healing will be evaluated radiographically and histologically.",[106],"The Application of Hyaluronic Acid on Teeth Bone Healing. Hyaluronic Acid Which is Widely Used in Medicine for Joint, Eye Care, Wound Healing",[108],"hyauronic acid, wisdom teeth extraction, bone healing","2026-01-27",{"date":111,"type":112},"2026-01-28","ACTUAL",{"date":114,"type":112},"2024-08-01",{"date":116,"type":100},"2026-04-30",{"name":5,"class":6},1]