[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100560242":3},{"organization":4,"outcomesModule":7,"designInfo":16,"detailedDescription":11,"studyPopulation":11,"armGroups":22,"interventions":33,"overallOfficials":42,"centralContacts":46,"locations":51,"responsibleParty":64,"collaborators":11,"id":68,"slug":11,"hasResults":69,"nctId":70,"briefTitle":71,"officialTitle":72,"acronym":11,"eligibilityCriteria":73,"healthyVolunteers":69,"sex":74,"minAge":75,"maxAge":11,"enrollmentInfo":76,"targetDuration":11,"studyType":79,"phases":80,"briefSummary":82,"conditions":83,"keywords":85,"overallStatus":53,"whyStopped":11,"lastUpdateSubmitDate":89,"lastUpdatePostDateStruct":90,"startDateStruct":93,"completionDateStruct":95,"leadSponsor":97,"locationsCount":98},{"fullName":5,"class":6},"Konkuk University Medical Center","OTHER",{"primaryOutcomes":8,"secondaryOutcomes":13,"otherOutcomes":11},[9],{"measure":10,"description":11,"timeFrame":12},"Cell-mediated immunity (CD4+ and CD8+ T cell against herpes zoster)",null,"baseline (before 1st vaccination), 1 months later from 2nd vaccination, 3 months later from 2nd vaccination",[14],{"measure":15,"description":11,"timeFrame":12},", Humoral immunity (anti-VZV antibody, anti-gE antibody)",{"allocation":17,"interventionModel":18,"interventionModelDescription":11,"primaryPurpose":19,"observationalModel":11,"timePerspective":11,"maskingInfo":20},"RANDOMIZED","PARALLEL","BASIC_SCIENCE",{"masking":21,"maskingDescription":11,"whoMasked":11},"NONE",[23,29],{"label":24,"type":25,"description":26,"interventionNames":27},"MTX discontinuation","EXPERIMENTAL","methotrexate stop for 2 weeks after each shingrix vaccination",[28],"Drug: Methotrexate",{"label":30,"type":31,"description":11,"interventionNames":32},"MTX continuation","ACTIVE_COMPARATOR",[28],[34,39],{"type":35,"name":36,"description":37,"armGroupLabels":38,"otherNames":11},"DRUG","Methotrexate","methotrexate discontinuation group : stop MTX for 2 weeks after each shingrix vaccination",[24],{"type":35,"name":36,"description":40,"armGroupLabels":41,"otherNames":11},"methotrexate continuation group : keep methotrexate",[30],[43],{"name":44,"affiliation":5,"role":45},"Hong Ki Min, MD, PhD","STUDY_CHAIR",[47],{"name":44,"role":48,"phone":49,"phoneExt":11,"email":50},"CONTACT","+82-10-9977-5455","alsghdrl1921@naver.com",[52],{"facility":5,"status":53,"city":54,"state":11,"zip":11,"country":55,"countryCode":11,"cosmosGeoPoint":56,"geoPoint":61,"contacts":62},"RECRUITING","Seoul","South Korea",{"type":57,"coordinates":58},"Point",[59,60],126.9784,37.566,{"lat":60,"lon":59},[63],{"name":44,"role":48,"phone":49,"phoneExt":11,"email":50},{"type":65,"investigatorFullName":66,"investigatorTitle":67,"investigatorAffiliation":5,"oldNameTitle":11,"oldOrganization":11},"PRINCIPAL_INVESTIGATOR","Hong Ki Min","Assistant Professor","100560242",false,"NCT06574594","Effect of MTX Discontinuation on Shingrix Response in RA","Effect of Methotrexate Discontinuation on Immunogenicity of Shingrix in Patients With Rheumatoid Arthritis","Inclusion Criteria:\n\n* fulfill 2010 ACR\u002FEULAR classification criteria for rheumatoid arthritis\n* age over 19 years\n* methotrexate user\n* agree for vaccination with shingrix\n\nExclusion Criteria:\n\n* have other form of inflammatory arthritis or autoimmune-mediated disease\n* malignancy, current infection, pregnancy","ALL","19 Years",{"count":77,"type":78},110,"ESTIMATED","INTERVENTIONAL",[81],"NA","The goal of this clinical trial is to learn if methotrexate discontinuation affect on immunogeneity of shingrix in RA patients. The main questions it aims to answer are:\n\nDiscontinuation of methotrexate after shingrix immunization increase efficacy of the vaccine in patients with RA ?\n\nResearchers will compare humoral and cell-mediated immunity against herpes zoster in RA patients who are vaccinated by shingrix, and compare these immunity between RA patients with MTX discontinuation and MTX continuation groups.\n\nParticipants will:\n\nVaccinated with shingrix twice. MTX continuation group will keep taking MTX after shingrix vaccination, whereas MTX discontinuation group will stop MTX for 2 weeks after shingrix vaccination.\n\nVisit the clinic at baseline (first shingrix vaccination), 2 months later for 2nd shingrix vaccination, then 3 \\& 6 months later from baseline to achieve blood sample.",[84],"Rheumatoid Arthritis",[86,87,88],"herpes zoster","Shingrix","methotrexate","2024-08-25",{"date":91,"type":92},"2024-08-28","ACTUAL",{"date":94,"type":78},"2024-08-22",{"date":96,"type":78},"2025-12-31",{"name":5,"class":6},1]