This study aims to investigate the impact of platelet concentrate (PC) transfusions on endothelial function and the systemic inflammatory response in thrombopenic patients admitted to intensive care who require prophylactic platelet transfusions.
Endothelial function will be measured using a laser Doppler device coupled with an acetylcholine iontophoresis system that is applied to the skin.
Adult patient ≥ 18 years of age
Admitted to intensive care
Requires prophylactic platelet transfusion for thrombocytopenia
Enrolled in a social security program
Recent platelet or red blood cell transfusion (< 24 hours)
Need for urgent red blood cell transfusion due to active bleeding
Patient under guardianship or conservatorship
Significant peripheral edema
Assistance Publique - Hôpitaux de Paris
Lead sponsor