[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100398423":3},{"organization":4,"armGroups":7,"interventions":21,"overallOfficials":26,"centralContacts":30,"locations":36,"responsibleParty":53,"collaborators":10,"id":55,"slug":10,"hasResults":56,"nctId":57,"briefTitle":58,"officialTitle":59,"acronym":10,"eligibilityCriteria":60,"healthyVolunteers":56,"sex":61,"minAge":62,"maxAge":63,"enrollmentInfo":64,"targetDuration":10,"studyType":67,"phases":10,"briefSummary":68,"conditions":69,"keywords":73,"overallStatus":38,"whyStopped":10,"lastUpdateSubmitDate":81,"lastUpdatePostDateStruct":82,"startDateStruct":85,"completionDateStruct":87,"leadSponsor":89,"locationsCount":90},{"fullName":5,"class":6},"Peking University Third Hospital","OTHER",[8,12,17],{"label":9,"type":10,"description":11,"interventionNames":10},"NS Group",null,"Patients without pre-existing degeneration at L3\u002F4 segment will be classified into control group (NS group).",{"label":13,"type":10,"description":14,"interventionNames":15},"D Group","Patients with pre-existing disc factors (Pfirrmann grade≥3, Hiz or vacuum sign) at L3\u002F4 segment will be classified into group D.",[16],"Other: Pre-existing degenerative factors at adjacent segment",{"label":18,"type":10,"description":19,"interventionNames":20},"C Group","Patients with pre-existing canal stenosis factors (cerebrospinal fluid occlusion≥1) at L3\u002F4 segment will be classified into group C.",[16],[22],{"type":6,"name":23,"description":24,"armGroupLabels":25,"otherNames":10},"Pre-existing degenerative factors at adjacent segment","Pre-existing degenerative factors at adjacent segment, including disc factors and canal stenosis factors",[18,13],[27],{"name":28,"affiliation":5,"role":29},"Wei Shi Li, Dr.","PRINCIPAL_INVESTIGATOR",[31],{"name":32,"role":33,"phone":34,"phoneExt":10,"email":35},"Zhuo Ran Sun, Dr.","CONTACT","+8618610292513","puh3_szr@outlook.com",[37],{"facility":5,"status":38,"city":39,"state":40,"zip":41,"country":42,"cosmosGeoPoint":43,"geoPoint":48,"contacts":49},"RECRUITING","Beijing","Beijing Municipality","100191","China",{"type":44,"coordinates":45},"Point",[46,47],116.39723,39.9075,{"lat":47,"lon":46},[50],{"name":51,"role":33,"phone":10,"phoneExt":10,"email":52},"Da Zou, M.D.","zd_puth@163.com",{"type":54,"investigatorFullName":10,"investigatorTitle":10,"investigatorAffiliation":10,"oldNameTitle":10,"oldOrganization":10},"SPONSOR","100398423",false,"NCT04467944","Effect of Pre-existing Adjacent Segment Degeneration on Long-term Effectiveness After Lumbar Fusion Surgery","Effect of Pre-existing Adjacent Segment Degeneration on Long-term Effectiveness After Lumbar Fusion Surgery: a Prospective Cohort Study","Inclusion Criteria:\n\n* A clear diagnosis of lumbar spinal stenosis, and surgical level of L4- S1 (The levels to be operated on were decided by matching the clinical symptomatology with the radiological findings of the spinal levels that needed decompression);\n* Failed at least eight weeks conservative treatment;\n\nExclusion Criteria:\n\n* Unstable factors (slip, rotation, lateral bending, etc.) in adjacent segment L3\u002F4;\n* Preoperative sagittal and coronal imbalance of the spine;\n* Lumbar infection and\u002For tumor diseases;\n* A previous history of lumbar fusion surgery.","ALL","18 Years","80 Years",{"count":65,"type":66},210,"ESTIMATED","OBSERVATIONAL","This is a prospective single-center study. Patients requiring posterior lumbar interbody fusion (PLIF) for lumbar degenerative disease are prospectively enrolled and followed. Important adjacent pre-existing degeneration factors include discs degenerated, facets and ligamentum flavum tropism which could lead to spinal canal stenosis (SCS). This study will focus on the effects of pre- existing adjacent degeneration (disc factors and spinal canal stenosis factors) on long-term postoperative outcomes.",[70,71,72],"Degenerative Lumbar Spinal Stenosis","Degenerative Disc Disease","Degeneration Spine",[74,75,76,77,78,79,80],"Cerebrospinal fluid occlusion","Pre-existing degeneration","Spinal canal stenosis","Adjacent segment degeneration","Adjacent segment disease","High-intensity zone","Vacuum sign","2020-07-08",{"date":83,"type":84},"2020-07-13","ACTUAL",{"date":86,"type":84},"2018-01-01",{"date":88,"type":66},"2032-12-31",{"name":5,"class":6},1]