[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100619692":3},{"organization":4,"outcomesModule":7,"designInfo":16,"detailedDescription":11,"studyPopulation":19,"armGroups":20,"interventions":29,"overallOfficials":11,"centralContacts":11,"locations":38,"responsibleParty":57,"collaborators":11,"id":61,"slug":11,"hasResults":62,"nctId":63,"briefTitle":64,"officialTitle":65,"acronym":11,"eligibilityCriteria":66,"healthyVolunteers":62,"sex":67,"minAge":68,"maxAge":11,"enrollmentInfo":69,"targetDuration":11,"studyType":72,"phases":11,"briefSummary":73,"conditions":74,"keywords":76,"overallStatus":41,"whyStopped":11,"lastUpdateSubmitDate":80,"lastUpdatePostDateStruct":81,"startDateStruct":84,"completionDateStruct":86,"leadSponsor":88,"locationsCount":89},{"fullName":5,"class":6},"Future University in Egypt","OTHER",{"primaryOutcomes":8,"secondaryOutcomes":13,"otherOutcomes":11},[9],{"measure":10,"description":11,"timeFrame":12},"In-hospital cardiac and renal events",null,"3 months",[14],{"measure":15,"description":11,"timeFrame":12},"NYHA classification",{"allocation":11,"interventionModel":11,"interventionModelDescription":11,"primaryPurpose":11,"observationalModel":17,"timePerspective":18,"maskingInfo":11},"COHORT","PROSPECTIVE","The study population consists of adult patients with heart failure and reduced ejection fraction who are admitted to the cardiology wards at Mansoura University Hospital (MUH) during the study period. Participants include those who were already receiving ARNI therapy prior to hospital admission and those who were not, representing typical patients seen in clinical practice.",[21,25],{"label":22,"type":11,"description":11,"interventionNames":23},"Prehospital ARNI users",[24],"Other: Prehospital ARNI use",{"label":26,"type":11,"description":11,"interventionNames":27},"Non-Prehospital ARNI users",[28],"Other: No prehospital ARNI use",[30,34],{"type":6,"name":31,"description":32,"armGroupLabels":33,"otherNames":11},"Prehospital ARNI use","Participants who were using ARNI therapy before hospital admission",[22],{"type":6,"name":35,"description":36,"armGroupLabels":37,"otherNames":11},"No prehospital ARNI use","Participants who were not using ARNI therapy before hospital admission",[26],[39],{"facility":40,"status":41,"city":42,"state":11,"zip":11,"country":43,"countryCode":44,"cosmosGeoPoint":45,"geoPoint":50,"contacts":51},"Mansoura university Hospital","RECRUITING","Al Mansurah","Egypt","EG",{"type":46,"coordinates":47},"Point",[48,49],31.38069,31.03637,{"lat":49,"lon":48},[52],{"name":53,"role":54,"phone":55,"phoneExt":11,"email":56},"Mansoura University Hospital","CONTACT","+201020296516","Hanaa.mm.abdelaziz@mans.edu.eg",{"type":58,"investigatorFullName":59,"investigatorTitle":60,"investigatorAffiliation":5,"oldNameTitle":11,"oldOrganization":11},"PRINCIPAL_INVESTIGATOR","Mrwan Ayman Ahmed Eassa","MS Student, Clinical Pharmacy Department, Future University in Egypt","100619692",false,"NCT07347925","Effect of Pre-Hospital ARNI Therapy on Short-Term Outcomes in HFrEF","Evaluating the Impact of Pre-Hospital Angiotensin Receptor-Neprilysin Inhibitor (ARNI) Therapy on Short-Term Clinical Outcomes in Heart Failure Patients With Reduced Ejection Fraction: A Comparative Study","Inclusion Criteria:\n\n* \\>= 18 years, male or female EF \\\u003C40%\n\nExclusion Criteria:\n\n* EF\\>40% Pregnancy or breastfeeding","ALL","18 Years",{"count":70,"type":71},140,"ESTIMATED","OBSERVATIONAL","This study looks at people with heart failure who are admitted to the hospital. The goal of the study is to understand whether taking a heart failure medicine called angiotensin receptor-neprilysin inhibitor (ARNI) before hospital admission affects short-term health outcomes.\n\nThe study will compare two groups of participants: those who were already taking ARNI before coming to the hospital and those who were not. Information will be collected from medical records during the hospital stay, including heart-related events, kidney-related events, and how long participants stay in the hospital.\n\nSome participants will also be followed for a short period after discharge. This study may help improve understanding of outcomes associated with ARNI use in people with heart failure in routine clinical care.",[75],"Heart Failure",[75,77,78,79],"NYHA class","Sacubitril\u002FValsartan","Chronic kidney disease","2026-01-11",{"date":82,"type":83},"2026-01-16","ACTUAL",{"date":85,"type":71},"2026-01-10",{"date":87,"type":71},"2026-05-01",{"name":5,"class":6},1]