[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100627742":3},{"organization":4,"outcomesModule":7,"designInfo":14,"detailedDescription":20,"studyPopulation":13,"armGroups":21,"interventions":34,"overallOfficials":13,"centralContacts":44,"locations":13,"responsibleParty":53,"collaborators":13,"id":57,"slug":13,"hasResults":58,"nctId":59,"briefTitle":60,"officialTitle":60,"acronym":61,"eligibilityCriteria":62,"healthyVolunteers":58,"sex":63,"minAge":64,"maxAge":65,"enrollmentInfo":66,"targetDuration":13,"studyType":69,"phases":70,"briefSummary":72,"conditions":73,"keywords":77,"overallStatus":80,"whyStopped":13,"lastUpdateSubmitDate":81,"lastUpdatePostDateStruct":82,"startDateStruct":85,"completionDateStruct":87,"leadSponsor":89,"locationsCount":13},{"fullName":5,"class":6},"Sohag University","OTHER",{"primaryOutcomes":8,"secondaryOutcomes":13,"otherOutcomes":13},[9],{"measure":10,"description":11,"timeFrame":12},"Control of infection","Improvement of manifestation according to rate of healing","6 months",null,{"allocation":15,"interventionModel":16,"interventionModelDescription":13,"primaryPurpose":17,"observationalModel":13,"timePerspective":13,"maskingInfo":18},"RANDOMIZED","PARALLEL","TREATMENT",{"masking":19,"maskingDescription":13,"whoMasked":13},"NONE","Prospective randomized control study to detect the effect of sodium chloride 5% solution as an adjuvant treatment with antimicrobial therapy in treatment of bacterial infectious keratits and to assess whether NaCl 5% accelerates epithelial healing, improves microbial eradication, and enhances visual outcomes in bacterial infectious keratitis.Data study will include two groups classified as follow : the first group will include treatment of microbial keratitis by antibiotic with sodium chloride 5% , the second group will include treatment by antibiotic only",[22,29],{"label":23,"type":24,"description":25,"interventionNames":26},"Intervention group","EXPERIMENTAL","treatment of microbial keratitis by antibiotic with sodium chloride 5%",[27,28],"Drug: Sodium chloride 5% solution","Drug: quinolones",{"label":30,"type":31,"description":32,"interventionNames":33},"Control group","ACTIVE_COMPARATOR","Treatment of microbial keratitis by antibiotics only",[28],[35,40],{"type":36,"name":37,"description":38,"armGroupLabels":39,"otherNames":13},"DRUG","Sodium chloride 5% solution","Use Sodium chloride 5% solution with usual anti microbial drugs",[23],{"type":36,"name":41,"description":42,"armGroupLabels":43,"otherNames":13},"quinolones","Use of usual topical anti microbial treatment only",[30,23],[45,50],{"name":46,"role":47,"phone":48,"phoneExt":13,"email":49},"Nancy Safwat Kaldas, Specialist","CONTACT","01200933440","nansy_safwat_post@med.sohag.edu.eg",{"name":51,"role":47,"phone":52,"phoneExt":13,"email":13},"Amr Mounir Mohamed, Assistant professor","01005026170",{"type":54,"investigatorFullName":55,"investigatorTitle":56,"investigatorAffiliation":5,"oldNameTitle":13,"oldOrganization":13},"PRINCIPAL_INVESTIGATOR","Nancy Safwat Kaldes","Principal Investigator","100627742",false,"NCT07452588","Effect of Sodium Chloride 5% Solution as an Adjuvant Treatment With Antimicrobial Therapy in the Treatment of Bacterial Infectious Keratitis","keratitis","IncluInclusion Criteria\n\n* Age ≥ 18 years.\n* Clinically diagnosed bacterial infectious keratitis\n* Positive corneal scraping or strong clinical suspicion of bacterial cause.\n* Ability to provide informed consent and attend follow-up visits\n\nExclusion Criteria:\n\n* • Fungal, viral, or acanthamoeba keratitis.\n\n  * Recent (\\\u003C7 days) topical corticosteroid use.\n  * Corneal perforation or impending perforation.\n  * History of hypersensitivity to study agents.\n  * Systemic immunocompromised state (uncontrolled diabetes, Human immune defecinicy virus).\n  * Poor compliance expected with follow-up.","ALL","18 Years","60 Years",{"count":67,"type":68},40,"ESTIMATED","INTERVENTIONAL",[71],"NA","This study aims to detect the effect of sodium chloride 5% solution as an adjuvant treatment with antimicrobial therapy in treatment of bacterial infectious keratits and to assess whether NaCl 5% accelerates epithelial healing, improves microbial eradication, and enhances visual outcomes in bacterial infectious keratitis.",[74,75,76],"Infectious Keratitis","Adjuvant Treatment Bacterial Infectious Keratitis","Sodium Chloride 5% Solution",[78,79],"Bacterial infectious keratitis","Sodiunchloride5%","NOT_YET_RECRUITING","2026-03-02",{"date":83,"type":84},"2026-03-05","ACTUAL",{"date":86,"type":68},"2026-02",{"date":88,"type":68},"2027-02",{"name":5,"class":6}]