[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100615647":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":25,"centralContacts":25,"locations":29,"responsibleParty":49,"collaborators":25,"id":53,"slug":25,"hasResults":54,"nctId":55,"briefTitle":56,"officialTitle":57,"acronym":25,"eligibilityCriteria":58,"healthyVolunteers":54,"sex":59,"minAge":60,"maxAge":61,"enrollmentInfo":62,"targetDuration":25,"studyType":65,"phases":66,"briefSummary":68,"conditions":69,"keywords":71,"overallStatus":32,"whyStopped":25,"lastUpdateSubmitDate":73,"lastUpdatePostDateStruct":74,"startDateStruct":77,"completionDateStruct":79,"leadSponsor":81,"locationsCount":82},{"fullName":5,"class":6},"Fondazione IRCCS Policlinico San Matteo di Pavia","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Cynacol","EXPERIMENTAL","Cynacol (developed by BioDue S.p.A.) is a dietary supplement containing, artichoke dry extract, naringin, Silybum marianum dry extract, flaxseed oil, vitamin E and sunflower oil.",[13],"Dietary Supplement: Cynacol",{"label":15,"type":16,"description":17,"interventionNames":18},"Metacol","ACTIVE_COMPARATOR","Metacol (developed by BioDue S.p.A.) is a dietary supplement containing coenzyme Q10, monacolin k and flax seed oil.",[19],"Dietary Supplement: Metacol",[21,26],{"type":22,"name":9,"description":23,"armGroupLabels":24,"otherNames":25},"DIETARY_SUPPLEMENT","Cynacol (developed by BioDue S.p.A.) containing, artichoke dry extract, naringin, Silybum marianum dry extract, flaxseed oil, vitamin E and sunflower oil, 2 capsules\u002Fday after dinner for 90 days",[9],null,{"type":22,"name":15,"description":27,"armGroupLabels":28,"otherNames":25},"Metacol (developed by BioDue S.p.A.) containing coenzyme Q10, monacolin k and flaxseed oil, 2 capsules\u002Fday after dinner for 90 days",[15],[30],{"facility":31,"status":32,"city":33,"state":34,"zip":35,"country":36,"cosmosGeoPoint":37,"geoPoint":42,"contacts":43},"Fondazione IRCCS Policlinico San Matteo","RECRUITING","Pavia","Lombardy","27100","Italy",{"type":38,"coordinates":39},"Point",[40,41],9.15917,45.19205,{"lat":41,"lon":40},[44],{"name":45,"role":46,"phone":47,"phoneExt":25,"email":48},"Giuseppe Derosa, MD, PhD","CONTACT","+390382502614","g.derosa@smatteo.pv.it",{"type":50,"investigatorFullName":51,"investigatorTitle":52,"investigatorAffiliation":5,"oldNameTitle":25,"oldOrganization":25},"PRINCIPAL_INVESTIGATOR","Giuseppe Derosa","Principal Investigator","100615647",false,"NCT07295327","Effect of Two Food Supplements on Lipid Profile in Patients With Mild Hypercholesterolemia","Randomized and Comparative Clinical Study on the Lipid-lowering Efficacy and Tolerability of Two Food Supplements in Mild Hypercholesterolemia","Inclusion Criteria:\n\n* age between 35-70 years\n* both genders\n* LDL-C levels between 115 and 190 mg\u002Fdl\n* subjects able to understand the informed consent and sign it before enrollment in the study\n\nExclusion Criteria:\n\n* personal history of cardiovascular disease or equivalent risk factors\n* Tg levels ≥ 400 mg\u002Fdl\n* obesity \\[body mass index (BMI) ≥ 30 kg\u002Fm²\\]\n* taking hypolipidemic drugs or supplements that affect lipid metabolism\n* diabetes mellitus\n* known thyroid, liver, kidney or muscle diseases\n* any medical or surgical condition that makes patient compliance with the study protocol complex or inconsistent\n* any known allergy or hypersensitivity to one or more components of the food supplements","ALL","35 Years","70 Years",{"count":63,"type":64},40,"ESTIMATED","INTERVENTIONAL",[67],"NA","The primary outcome is to evaluate the effect of Cynacol on the change in LDL-C levels compared to Metacol after 90 days of supplementation.\n\nThe secondary outcomes are to evaluate:\n\n\\- the change of TC, non-HDL cholesterol (non-HDL-C), apolipoprotein B (apoB), Tg, HDL-C levels after 90 days of supplementation with Cynacol compared to Metacol. The safety outcome is collection of the adverse events not related, related or possibly related to the study products.",[70],"Hypercholesterolemia",[70,72],"Food supplement","2025-12-08",{"date":75,"type":76},"2025-12-19","ACTUAL",{"date":78,"type":76},"2025-09-30",{"date":80,"type":64},"2026-03-31",{"name":5,"class":6},1]