Effect of Vitamin A Supplementation on Idiopathic Scoliosis
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age6-15
SponsorSecond Affiliated Hospital of Wenzhou Medical University
About this trial
This study aims to investigate whether vitamin A supplementation can influence spinal curve magnitude in idiopathic scoliosis children and potentially prevent its de novo development.
Eligibility criteria
Qualifiers
Age between 6 and 15 years.
Biochemically confirmed vitamin A deficiency (serum retinol < 0.20 mg/L) or insufficiency (serum retinol 0.20-0.29 mg/L).
Has undergone radiographic evaluation (standing full-spine X-ray) for idiopathic scoliosis at the initial clinic visit.
Skeletally immature (Risser sign 0-3) with a major Cobb angle < 40 degrees at baseline.
Disqualifiers
Unwillingness or inability to comply with all study procedures and follow-up visits.
Plans to relocate outside the study area within the next 24 months.
Previous high-dose vitamin A supplementation therapy within the past 12 months.
Clinical signs of severe vitamin A deficiency syndrome (e.g., xerophthalmia, Bitot's spots).
Trial design
Treatments tested in this trial
- Vitamin A
- Nutritional Education
Treatment groups
140 Participants
are divided into 2 treatment groupsLocations
1The Second Affiliated Hospital of Wenzhou Medical University325000, WenzhouZhejiang, China
Sponsors and collaborators
Second Affiliated Hospital of Wenzhou Medical University
Lead sponsor
The Children's Hospital of Zhejiang University School of Medicine
Collaborator
Ningbo No. 1 Hospital
Collaborator
Ningbo No.2 Hospital
Collaborator
The Third Affiliated Hospital of Wenzhou Medical University
Collaborator
Source ClinicalTrials.gov