[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100595367":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":26,"centralContacts":31,"locations":37,"responsibleParty":258,"collaborators":26,"id":260,"slug":26,"hasResults":261,"nctId":262,"briefTitle":263,"officialTitle":264,"acronym":265,"eligibilityCriteria":266,"healthyVolunteers":261,"sex":267,"minAge":268,"maxAge":269,"enrollmentInfo":270,"targetDuration":26,"studyType":273,"phases":274,"briefSummary":276,"conditions":277,"keywords":279,"overallStatus":58,"whyStopped":26,"lastUpdateSubmitDate":285,"lastUpdatePostDateStruct":286,"startDateStruct":289,"completionDateStruct":291,"leadSponsor":293,"locationsCount":294},{"fullName":5,"class":6},"China National Center for Cardiovascular Diseases","OTHER_GOV",[8,15],{"label":9,"type":10,"description":11,"interventionNames":12},"AI-Enabled Stratified Management Group","EXPERIMENTAL","Participants in the intervention group will use SMART-CHD alongside usual post-discharge care.",[13,14],"Combination Product: AI-Enabled Stratified Management System","Combination Product: Usual Post-Discharge Care",{"label":16,"type":17,"description":18,"interventionNames":19},"Usual Post-Discharge Care Group","ACTIVE_COMPARATOR","Participants in the control group will receive usual discharge protocol comprising verbal and printed discharge instructions addressing medication schedules, follow-up timelines, and lifestyle optimization strategies.",[14],[21,27],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"COMBINATION_PRODUCT","AI-Enabled Stratified Management System","After discharge, participants install SMART-CHD, sync their EHR data, and complete a 10-minute orientation. They then use the app's OCR-assisted surveys to report lifestyle, lab, and event data, while paired wearables stream continuous vitals. AI voice calls and a CRC-managed WeChat group deliver reminders and support. The app's embedded predictive models stratify them into risk tiers and generate tier-specific follow-up schedules. Personalized lifestyle modification guidance, dietary plans, and medication adjustment recommendations are generated by the platform's module. Automated alerts and teleconsultation options are triggered upon detection of high-risk signs or abnormal results, ensuring timely clinical intervention and enhanced secondary prevention.",[9],null,{"type":22,"name":28,"description":29,"armGroupLabels":30,"otherNames":26},"Usual Post-Discharge Care","Usual discharge protocol comprising verbal and printed discharge instructions addressing medication schedules, follow-up timelines, and lifestyle optimization strategies.",[9,16],[32],{"name":33,"role":34,"phone":35,"phoneExt":26,"email":36},"Gao Prof. Gao, MD, PhD","CONTACT","010-88322413","sophie_gao@sina.com",[38,56,70,85,100,110,125,139,149,158,173,187,202,213,228,243],{"facility":39,"status":40,"city":41,"state":42,"zip":43,"country":44,"cosmosGeoPoint":45,"geoPoint":50,"contacts":51},"The First Affiliated Hospital of University of Science and Technology of China","NOT_YET_RECRUITING","Hefei","Anhui","230001","China",{"type":46,"coordinates":47},"Point",[48,49],117.28083,31.86389,{"lat":49,"lon":48},[52],{"name":53,"role":34,"phone":54,"phoneExt":26,"email":55},"Ke Meng","19995377625","19995377625@163.com",{"facility":57,"status":58,"city":59,"state":60,"zip":61,"country":44,"cosmosGeoPoint":62,"geoPoint":66,"contacts":67},"Fuwai Hospital, Chinese Academy of Medical Sciences\u002FNational Center for Cardiovascular Diseases","RECRUITING","Beijing","Beijing Municipality","100037",{"type":46,"coordinates":63},[64,65],116.39723,39.9075,{"lat":65,"lon":64},[68],{"name":33,"role":34,"phone":69,"phoneExt":26,"email":36},"+86 8832 2413",{"facility":71,"status":40,"city":72,"state":73,"zip":74,"country":44,"cosmosGeoPoint":75,"geoPoint":79,"contacts":80},"Fuwai Hospital Chinese Academy of Medical Sciences, Shenzhen","Shenzhen","Guangdong","518057",{"type":46,"coordinates":76},[77,78],114.0683,22.54554,{"lat":78,"lon":77},[81],{"name":82,"role":34,"phone":83,"phoneExt":26,"email":84},"Fenghuan Hu, MD","0755-25509566","hufenghuanvip@163.com",{"facility":86,"status":40,"city":87,"state":88,"zip":89,"country":44,"cosmosGeoPoint":90,"geoPoint":94,"contacts":95},"The First Hospital of Hebei Medical University","Shijiazhuang","Hebei","050000",{"type":46,"coordinates":91},[92,93],114.47861,38.04139,{"lat":93,"lon":92},[96],{"name":97,"role":34,"phone":98,"phoneExt":26,"email":99},"Fangfang Ma","13932108925","fad@hebmu.edu.cn",{"facility":101,"status":40,"city":87,"state":88,"zip":89,"country":44,"cosmosGeoPoint":102,"geoPoint":104,"contacts":105},"The Second Hospital Of Hebe Medical University",{"type":46,"coordinates":103},[92,93],{"lat":93,"lon":92},[106],{"name":107,"role":34,"phone":108,"phoneExt":26,"email":109},"Xinshun Gu","0311-66636037","pub@hb2h.com",{"facility":111,"status":40,"city":112,"state":113,"zip":114,"country":44,"cosmosGeoPoint":115,"geoPoint":119,"contacts":120},"The First Affiliated Hospital of Henan University of Science and Technology","Luoyang","Henan","471003",{"type":46,"coordinates":116},[117,118],112.43684,34.67345,{"lat":118,"lon":117},[121],{"name":122,"role":34,"phone":123,"phoneExt":26,"email":124},"Mengjuan Xu","15903076908","zhijuanli66@sina.com",{"facility":126,"status":40,"city":127,"state":113,"zip":128,"country":44,"cosmosGeoPoint":129,"geoPoint":133,"contacts":134},"Henan Provincial Chest Hospital","Zhengzhou","450000",{"type":46,"coordinates":130},[131,132],113.64861,34.75778,{"lat":132,"lon":131},[135],{"name":136,"role":34,"phone":137,"phoneExt":26,"email":138},"Zhe Peng","15538128220","15538128220@qq.com",{"facility":140,"status":40,"city":127,"state":113,"zip":128,"country":44,"cosmosGeoPoint":141,"geoPoint":143,"contacts":144},"Zhengzhou University Affiliated Zhengzhou Central Hospital",{"type":46,"coordinates":142},[131,132],{"lat":132,"lon":131},[145],{"name":146,"role":34,"phone":147,"phoneExt":26,"email":148},"Xiaojie Yang","18631423366","18631423366@163.com",{"facility":150,"status":40,"city":127,"state":113,"zip":128,"country":44,"cosmosGeoPoint":151,"geoPoint":153,"contacts":154},"Zhengzhou University Fuwai Central China Cardiovascular Hospital",{"type":46,"coordinates":152},[131,132],{"lat":132,"lon":131},[155],{"name":156,"role":34,"phone":98,"phoneExt":26,"email":157},"You Zhang","gaocy6802@163.com",{"facility":159,"status":40,"city":160,"state":161,"zip":162,"country":44,"cosmosGeoPoint":163,"geoPoint":167,"contacts":168},"The First Affiliated Hospital of Nanjing Medical University","Nanjing","Jiangsu","210029",{"type":46,"coordinates":164},[165,166],118.77778,32.06167,{"lat":166,"lon":165},[169],{"name":170,"role":34,"phone":171,"phoneExt":26,"email":172},"Jiabao Liu, MD","025-68303127","jiabaoliu@njmu.edu.cn",{"facility":174,"status":40,"city":175,"state":161,"zip":176,"country":44,"cosmosGeoPoint":177,"geoPoint":181,"contacts":182},"Northern Jiangsu People's Hospital","Yangzhou","225001",{"type":46,"coordinates":178},[179,180],119.43583,32.39722,{"lat":180,"lon":179},[183],{"name":184,"role":34,"phone":185,"phoneExt":26,"email":186},"Jing Yang","18512178336","nyxb1980@163.com",{"facility":188,"status":40,"city":189,"state":190,"zip":191,"country":44,"cosmosGeoPoint":192,"geoPoint":196,"contacts":197},"The Second Affiliated Hospital of Xi'an Jiaotong University","Xi'an","Shaanxi","710004",{"type":46,"coordinates":193},[194,195],108.92861,34.25833,{"lat":195,"lon":194},[198],{"name":199,"role":34,"phone":200,"phoneExt":26,"email":201},"Jie Liu","029-87679000","eyshce@126.com",{"facility":203,"status":40,"city":189,"state":190,"zip":204,"country":44,"cosmosGeoPoint":205,"geoPoint":207,"contacts":208},"The First Affiliated Hospital of Xi'an Jiaotong University","710061",{"type":46,"coordinates":206},[194,195],{"lat":195,"lon":194},[209],{"name":210,"role":34,"phone":211,"phoneExt":26,"email":212},"Huan Wu, MD","029-85323211","1279952786@qq.com",{"facility":214,"status":40,"city":215,"state":216,"zip":217,"country":44,"cosmosGeoPoint":218,"geoPoint":222,"contacts":223},"Shanxi Cardiovascular Disease Hospital","Taiyuan","Shanxi","030024",{"type":46,"coordinates":219},[220,221],112.56028,37.86944,{"lat":221,"lon":220},[224],{"name":225,"role":34,"phone":226,"phoneExt":26,"email":227},"Jingyi Liu","18235123471","18235123471@163.com",{"facility":229,"status":40,"city":230,"state":231,"zip":232,"country":44,"cosmosGeoPoint":233,"geoPoint":237,"contacts":238},"The Affiliated Hospital of Southwest Medical University","Luzhou","Sichuan","400042",{"type":46,"coordinates":234},[235,236],105.42575,28.8903,{"lat":236,"lon":235},[239],{"name":240,"role":34,"phone":241,"phoneExt":26,"email":242},"Ling Wu, MD","0830-3165101","wulingzt@163.com",{"facility":244,"status":40,"city":245,"state":246,"zip":247,"country":44,"cosmosGeoPoint":248,"geoPoint":252,"contacts":253},"The Second Affiliated Hospital, School of Medicine, Zhejiang University","Hangzhou","Zhejiang","310009",{"type":46,"coordinates":249},[250,251],120.16142,30.29365,{"lat":251,"lon":250},[254],{"name":255,"role":34,"phone":256,"phoneExt":26,"email":257},"Bingchen Liu, MD","0571-87783777","liubingchen111@zju.edu.cn",{"type":259,"investigatorFullName":26,"investigatorTitle":26,"investigatorAffiliation":26,"oldNameTitle":26,"oldOrganization":26},"SPONSOR","100595367",false,"NCT07031531","Effectiveness of an AI-Enabled Stratified Management System for Premature Coronary Artery Disease","Effectiveness of an AI-Enabled Stratified Management System for Premature Coronary Artery Disease (SMART-CHD): A Prospective, Multicenter, Open-Label, Randomized Controlled Trial","SMART-CHD","Inclusion Criteria\n\n1. Patients with coronary heart disease aged 18-45 years;\n2. The patient or a close family member is capable of using a smartphone and mobile application (App);\n3. Willing to participate in the study and able to provide written informed consent.\n\nExclusion Criteria\n\n1. Severe cognitive impairment;\n2. Advanced-stage malignancy;\n3. Life expectancy less than 12 months;\n4. Severe multi-organ failure;\n5. Refusal to provide written informed consent.","ALL","18 Years","45 Years",{"count":271,"type":272},4900,"ESTIMATED","INTERVENTIONAL",[275],"NA","The goal of this clinical trial is to learn if an AI-enabled stratified management system (SMART-CHD) can improve post-discharge outcomes in adults aged 18-45 with premature coronary artery disease. The main questions it aims to answer are:\n\n1. Does SMART-CHD reduce the combined rate of all-cause death, myocardial infarction, stroke and rehospitalization within 12 months?\n2. Does SMART-CHD achieve better control of modifiable risk factors compared with usual care?\n\nResearchers will compare SMART-CHD to standard discharge management (verbal and printed instructions on medications, follow-up timelines and lifestyle advice) to see if the AI-driven platform leads to fewer adverse events and improved risk-factor profiles.\n\nParticipants will:\n\n1. Install and use the SMART-CHD mobile app after a 10-minute structured orientation session with supervised simulations.\n2. Complete regular in-app surveys on lifestyle behaviors, laboratory\u002Fimaging results and clinical events (with OCR-powered LLM assistance).\n3. Wear paired sensors for continuous monitoring of blood pressure, heart rate and other physiologic metrics.\n4. Receive automated EHR data harvesting, AI-driven voice-call reminders, and real-time CRC support via a dedicated WeChat group.\n5. Follow personalized, guideline-based risk-factor recommendations (diet, exercise, sleep, weight, smoking, alcohol, hypertension, dyslipidemia, diabetes).",[278],"Premature Coronary Heart Disease",[280,281,282,283,284],"Premature coronary heart disease","secondary prevention","long-term management","mobile health","artificial intelligence","2025-09-18",{"date":287,"type":288},"2025-09-23","ACTUAL",{"date":290,"type":288},"2025-08-08",{"date":292,"type":272},"2027-07-31",{"name":5,"class":6},16]