[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100628634":3},{"organization":4,"armGroups":7,"interventions":28,"overallOfficials":51,"centralContacts":55,"locations":65,"responsibleParty":88,"collaborators":59,"id":91,"slug":59,"hasResults":92,"nctId":93,"briefTitle":94,"officialTitle":95,"acronym":59,"eligibilityCriteria":96,"healthyVolunteers":97,"sex":98,"minAge":99,"maxAge":59,"enrollmentInfo":100,"targetDuration":59,"studyType":103,"phases":104,"briefSummary":106,"conditions":107,"keywords":110,"overallStatus":68,"whyStopped":59,"lastUpdateSubmitDate":122,"lastUpdatePostDateStruct":123,"startDateStruct":126,"completionDateStruct":128,"leadSponsor":130,"locationsCount":131},{"fullName":5,"class":6},"Universitat Internacional de Catalunya","OTHER",[8,16,20,24],{"label":9,"type":10,"description":11,"interventionNames":12},"Digital tray with reservoir","EXPERIMENTAL","Customized digital (3D-printed CAD-CAM) bleaching tray with reservoir design for at-home bleaching with 10% carbamide peroxide.",[13,14,15],"Procedure: Customized bleaching tray fabrication","Procedure: Reservoir tray design","Drug: Carbamide peroxide 10%",{"label":17,"type":10,"description":18,"interventionNames":19},"Digital tray without reservoir","Customized digital (3D-printed CAD-CAM) bleaching tray without reservoir design for at-home bleaching with 10% carbamide peroxide.",[13,14,15],{"label":21,"type":10,"description":22,"interventionNames":23},"Conventional tray with reservoir","Customized conventional vacuum-formed bleaching tray with reservoir design for at-home bleaching with 10% carbamide peroxide.",[13,14,15],{"label":25,"type":10,"description":26,"interventionNames":27},"Conventional tray without reservoir","Customized conventional vacuum-formed bleaching tray without reservoir design for at-home bleaching with 10% carbamide peroxide.",[13,14,15],[29,37,44],{"type":30,"name":31,"description":32,"armGroupLabels":33,"otherNames":34},"PROCEDURE","Customized bleaching tray fabrication","Customized bleaching trays were fabricated using either a conventional vacuum-forming technique or a digital CAD-CAM 3D-printing technique, according to randomized allocation within a split-mouth design.",[21,25,9,17],[35,36],"Conventional vacuum-formed tray fabrication","Digital 3D-printed CAD-CAM tray fabrication",{"type":30,"name":38,"description":39,"armGroupLabels":40,"otherNames":41},"Reservoir tray design","Tray designs were prepared either with a reservoir or without a reservoir, according to randomized allocation across hemiarches within the split-mouth design.",[21,25,9,17],[42,43],"With reservoir","Without reservoir",{"type":45,"name":46,"description":47,"armGroupLabels":48,"otherNames":49},"DRUG","Carbamide peroxide 10%","At-home bleaching gel containing 10% carbamide peroxide applied in customized trays according to the study protocol",[21,25,9,17],[50],"10% carbamide peroxide bleaching gel",[52],{"name":53,"affiliation":5,"role":54},"MARTA VALLES, DDS, PhD","PRINCIPAL_INVESTIGATOR",[56,61],{"name":53,"role":57,"phone":58,"phoneExt":59,"email":60},"CONTACT","+34619747903",null,"mvalles@uic.es",{"name":62,"role":57,"phone":63,"phoneExt":59,"email":64},"LISSETHE PEÑATE, DDS, PhD","+34 679 81 52 13","lissethe@uic.es",[66],{"facility":67,"status":68,"city":69,"state":70,"zip":71,"country":72,"cosmosGeoPoint":73,"geoPoint":78,"contacts":79},"Clínica Universitària d'Odontologia UIC Barcelona","RECRUITING","Sant Cugat del Vallès","BARCELONA","08195","Spain",{"type":74,"coordinates":75},"Point",[76,77],2.08611,41.47063,{"lat":77,"lon":76},[80,83,85,86],{"name":81,"role":57,"phone":82,"phoneExt":59,"email":60},"MARTA VALLES, Principal Investigator","619747903",{"name":84,"role":57,"phone":59,"phoneExt":59,"email":64},"LISSETHE PEÑATE, Sub Investigator",{"name":53,"role":54,"phone":59,"phoneExt":59,"email":59},{"name":62,"role":87,"phone":59,"phoneExt":59,"email":59},"SUB_INVESTIGATOR",{"type":54,"investigatorFullName":89,"investigatorTitle":90,"investigatorAffiliation":5,"oldNameTitle":59,"oldOrganization":59},"Marta Vallés Rodríguez","DDS, phD","100628634",false,"NCT07464197","Effectiveness of Dental Bleaching Using Different Designs of 3D-Printed and Conventional Customized Nightguards","Evaluation of the Effectiveness in Dental Bleaching by Different Designs of 3D-Printed Digital Customized Nightguards","Inclusion Criteria:\n\n* Adults aged 18 years or older\n* Good general and oral health\n* No current medical treatment (self-reported)\n* No need for surgical, endodontic, periodontal, or restorative dental treatment\n* At least six upper and six lower anterior teeth free of caries and restorations\n* Maxillary central incisors with baseline shade A2 or darker\n* Willingness to follow the study protocol and use the study-provided oral hygiene products\u002Finstructions\n\nExclusion Criteria:\n\n* Previous tooth bleaching treatment\n* Orthodontic appliances or prostheses that interfere with treatment\n* Severe intrinsic discoloration (e.g., tetracycline staining, fluorosis, or endodontically treated teeth with discoloration)\n* Pregnancy or lactation\n* Bruxism\n* Gingival recession, dentin exposure, visible enamel cracks, or other conditions associated with increased sensitivity\n* Use of anti-inflammatory or analgesic medication during the study period (according to protocol)",true,"ALL","18 Years",{"count":101,"type":102},40,"ESTIMATED","INTERVENTIONAL",[105],"NA","This randomized, double-blind, split-mouth clinical trial evaluates the effectiveness of at-home dental bleaching using customized nightguards fabricated by digital (3D-printed CAD-CAM) and conventional methods, with and without reservoirs. Adult participants with good general and oral health and a baseline tooth shade of A2 or darker undergo bleaching with 10% carbamide peroxide. Outcomes include tooth color change (subjective and spectrophotometric measures), tooth sensitivity, gingival irritation, patient comfort, and patient satisfaction over time.",[108,109],"Tooth Discoloration","Tooth Staining",[111,112,113,114,115,116,117,118,119,120,121],"dental bleaching","custom tray","3D-printed tray","CAD-CAM","Carbamide peroxide","Nightguard vital bleaching","Tooth sensitivity","Gingival irritation","Spectrophotometer","Split-mouth trial","tooth whitening","2026-03-11",{"date":124,"type":125},"2026-03-16","ACTUAL",{"date":127,"type":125},"2022-05-01",{"date":129,"type":102},"2026-07",{"name":5,"class":6},1]