[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100638905":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":31,"centralContacts":41,"locations":49,"responsibleParty":66,"collaborators":26,"id":69,"slug":26,"hasResults":70,"nctId":71,"briefTitle":72,"officialTitle":73,"acronym":26,"eligibilityCriteria":74,"healthyVolunteers":70,"sex":75,"minAge":76,"maxAge":77,"enrollmentInfo":78,"targetDuration":26,"studyType":81,"phases":82,"briefSummary":84,"conditions":85,"keywords":87,"overallStatus":51,"whyStopped":26,"lastUpdateSubmitDate":90,"lastUpdatePostDateStruct":91,"startDateStruct":94,"completionDateStruct":96,"leadSponsor":98,"locationsCount":99},{"fullName":5,"class":6},"Shaikh Zayed Hospital, Lahore","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Standard Fibromyalgia treatment plus Magnesium glycinate supplement","EXPERIMENTAL","participants who meet ACR 2016 fibromyalgia criteria and have shown no improvement after at least two months of single standard therapy (amitriptyline, duloxetine, pregabalin) will be recruited from rheumatology clinics and magnesium glycinate 850 mg once daily at night for 24 weeks.\n\n\\- 4 weekly follow-ups will be advised to monitor adherence, side effects, and any changes in concurrent medications, while pill counts and patient diaries will be used to verify compliance. On 4 weekly follow up visits will repeat the FIQ, WPI\u002FSSS, and record adverse events; serum magnesium and renal panels will be re measured at week 12 and 24.",[13],"Dietary Supplement: Magnesium glycinate",{"label":15,"type":16,"description":17,"interventionNames":18},"Standard FM treatment plus Vitamin supplement as placebo","PLACEBO_COMPARATOR","participants who meet ACR 2016 fibromyalgia criteria and have shown no improvement after at least two months of single standard therapy (amitriptyline, duloxetine, pregabalin) will be recruited from rheumatology clinics and vitamin supplement as placebo once daily at night for 24 weeks.\n\n\\- 4 weekly follow-ups will be advised to monitor adherence, side effects, and any changes in concurrent medications, while pill counts and patient diaries will be used to verify compliance. On 4 weekly follow up visits will repeat the FIQ, WPI\u002FSSS, and record adverse events; serum magnesium and renal panels will be re measured at week 12 and 24.",[19],"Dietary Supplement: Vitamins",[21,27],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"DIETARY_SUPPLEMENT","Magnesium glycinate","Fibromyalgia patients who have shown no improvement after at least two months of single standard therapy (amitriptyline, duloxetine, pregabalin) will be recruited from rheumatology clinics. Half participant randomly will be assigned to receive oral magnesium glycinate 850 mg once daily at night for 24 weeks.",[9],null,{"type":22,"name":28,"description":29,"armGroupLabels":30,"otherNames":26},"Vitamins","Fibromyalgia patients who have shown no improvement after at least two months of single standard therapy (amitriptyline, duloxetine, pregabalin) will be recruited from rheumatology clinics. Half participant will be randomly assigned to receive oral placebo (vitamin supplement) daily for 24 weeks.",[15],[32,35,38],{"name":33,"affiliation":5,"role":34},"Masooma Hashmat, FCPS","PRINCIPAL_INVESTIGATOR",{"name":36,"affiliation":5,"role":37},"Ayesha Humayun, FCPS, PhD","STUDY_CHAIR",{"name":39,"affiliation":5,"role":40},"Aflak Rasheed, FCPS","STUDY_DIRECTOR",[42,46],{"name":33,"role":43,"phone":44,"phoneExt":26,"email":45},"CONTACT","+923353053304","masoomahashmat@gmail.com",{"name":36,"role":43,"phone":47,"phoneExt":26,"email":48},"+923214343065","drayeshah@gmail.com",[50],{"facility":5,"status":51,"city":52,"state":53,"zip":54,"country":55,"cosmosGeoPoint":56,"geoPoint":61,"contacts":62},"RECRUITING","Lahore","Punjab Province","45000","Pakistan",{"type":57,"coordinates":58},"Point",[59,60],74.35071,31.558,{"lat":60,"lon":59},[63,64],{"name":33,"role":43,"phone":44,"phoneExt":26,"email":45},{"name":36,"role":43,"phone":47,"phoneExt":26,"email":65},"ayeshah@gmil.com",{"type":34,"investigatorFullName":67,"investigatorTitle":68,"investigatorAffiliation":5,"oldNameTitle":26,"oldOrganization":26},"Masooma Hashmat","DR.","100638905",false,"NCT07585045","Effectiveness of Oral Magnesium Supplementation in Fibromyalgia Patients Not Responding to Standard Treatment","Effectiveness of Oral Magnesium Supplementation in Fibromyalgia Patients Not Responding to Standard Treatment: A Randomized Clinical Trial Using Revised Fibromyalgia Impact Questionnaire","Inclusion Criteria:\n\n1. Patients diagnosed with FM according to the American College of Rheumatology (ACR) 2016 criteria\n2. Age: 18-65 years.\n3. Not responding to conventional treatment (e.g., amitriptyline, duloxetine, pregabalin) for at least 8 weeks\n4. Patients giving informed consent for enrollment in the study.\n\nExclusion Criteria:\n\n* 1- Patients with renal impairment 2- Pregnant or lactating women 3- Already on magnesium or other mineral supplements 4- Known cases of inflammatory arthritis or other chronic pain syndromes","ALL","18 Years","65 Years",{"count":79,"type":80},86,"ESTIMATED","INTERVENTIONAL",[83],"NA","Fibromyalgia is a complex widespread pain disorder. OBJECTIVES To evaluate the effectiveness of oral magnesium supplementation in reducing symptom severity among fibromyalgia patients who have not responded to standard treatment, using validated scoring systems such as the Fibromyalgia Impact Questionnaire Revised (FIQR).",[86],"Fibromyalgia",[86,88,89],"Magnesium supplement","Revised Fibromyalgia Impact Questionnaire","2026-05-08",{"date":92,"type":93},"2026-05-13","ACTUAL",{"date":95,"type":93},"2026-04-16",{"date":97,"type":80},"2027-02-26",{"name":5,"class":6},1]