Chronic kidney disease (CKD) and periodontitis share a bidirectional inflammatory relationship, with cytokines such as IL-6, TNF-α, and hsCRP driving progression in both conditions. Non-surgical periodontal therapy (NSPT) has shown reductions in systemic inflammatory markers with emerging evidence of improved renal function, yet robust randomized controlled trials targeting pre-dialysis stage IV-V diabetic CKD patients remain lacking. In the Indian context, where diabetes-related CKD is rapidly rising and access to dialysis is limited, there is a clear lacuna in literature regarding the effectiveness of NSPT in delaying progression to end-stage renal disease. Hence, the present non-randomized clinical study is undertaken to address this gap.
Patients aged 40-70 years.
Type 2 diabetes mellitus with chronic kidney disease and currently on oral hypoglycaemic agents.
Diagnosed with Stage IV or V (eGFR between 15-20 mL/min/1.73m²).
Not undergoing dialysis.
Patients already undergoing haemodialysis or renal transplantation.
Patients on insulin therapy or taking SGLT2 inhibitors and GLP-1 receptor agonists.
HbA1c level >8 %.
Any Periodontal therapy within past 6 months.
Postgraduate Institute of Dental Sciences Rohtak
Lead sponsor