[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100435883":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":29,"centralContacts":33,"locations":38,"responsibleParty":52,"collaborators":25,"id":54,"slug":25,"hasResults":55,"nctId":56,"briefTitle":57,"officialTitle":58,"acronym":59,"eligibilityCriteria":60,"healthyVolunteers":55,"sex":61,"minAge":62,"maxAge":25,"enrollmentInfo":63,"targetDuration":25,"studyType":66,"phases":67,"briefSummary":69,"conditions":70,"keywords":25,"overallStatus":40,"whyStopped":25,"lastUpdateSubmitDate":72,"lastUpdatePostDateStruct":73,"startDateStruct":76,"completionDateStruct":78,"leadSponsor":80,"locationsCount":81},{"fullName":5,"class":6},"Centre Hospitalier Henri Laborit","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"classic rTMS treatment","ACTIVE_COMPARATOR","Arm A: classic rTMS treatment (use of the 8-shaped coil) and standard therapy",[13],"Device: classic rTMS using the 8-shaped coil",{"label":15,"type":10,"description":16,"interventionNames":17},"treatment with deep rTMS","Arm B: treatment with deep rTMS (use of the H1-shaped coil (helmet)) and standard therapies",[18],"Device: deep rTMS using the H1-shaped coil",[20,26],{"type":21,"name":22,"description":23,"armGroupLabels":24,"otherNames":25},"DEVICE","classic rTMS using the 8-shaped coil","20 rTMS sessions are planned (5 sessions per week)",[9],null,{"type":21,"name":27,"description":23,"armGroupLabels":28,"otherNames":25},"deep rTMS using the H1-shaped coil",[15],[30],{"name":31,"affiliation":5,"role":32},"Ghina HARIKA-GERMANEAU, Dr","PRINCIPAL_INVESTIGATOR",[34],{"name":31,"role":35,"phone":36,"phoneExt":25,"email":37},"CONTACT","0033 5 16 52 61 18","ghina.harika-germaneau@ch-poitiers.fr",[39],{"facility":5,"status":40,"city":41,"state":25,"zip":25,"country":42,"cosmosGeoPoint":43,"geoPoint":48,"contacts":49},"RECRUITING","Poitiers","France",{"type":44,"coordinates":45},"Point",[46,47],0.34348,46.58261,{"lat":47,"lon":46},[50],{"name":51,"role":35,"phone":25,"phoneExt":25,"email":25},"Ghina Harika-Germaneau, MD, PhD",{"type":53,"investigatorFullName":25,"investigatorTitle":25,"investigatorAffiliation":25,"oldNameTitle":25,"oldOrganization":25},"SPONSOR","100435883",false,"NCT04956016","Effects of a Classic High-frequency rTMS Treatment Versus a Deep rTMS Treatment","Open-label Randomized Comparative Study of the Effects of a Classic High-frequency rTMS Treatment Versus a Deep rTMS Treatment in the Management of Resistant Depression","HAUVERDEEP","Inclusion Criteria:\n\n* Volunteer subjects over 18 years old\n* Having signed a free and informed consent\n* Having a diagnostic of caracterised depressive episod recurrent or isolated according to DSM IV criteria (A.P.A 1994).\n* Having an antidepressant treatment not modified since 3 weeks\n* Score to MADRS scale ≥ 21\n* Subject affiliated to a social security regimen\n\nExclusion Criteria:\n\n* Depression with psychotic caracteristics\n* Co-morbid diagnosis according to axis I (DSM IV) of schizophrenia, dependence (or abuse) on alcohol and \u002F or another substance (lifetime)\n* Patient who has already undergone seismotherapy for current episode and non-responder to this treatment\n* Patient hospitalized under duress or under legal protection (guardianship, curatorship)\n* Patient with a high risk of suicide (item 10 of MADRS \\> 4) in the absence of hospitalization.\n* Contra-indication for IRM exam or rTMS : personnal history of comitial crisis, of neurological or neurochirurgical pathologies, metallic prosthetic material or foreign body (pacemaker, intraoculare ferromagnetic material, implanted cardiac defibrillator, cochlear implant, metal clip\n* Pregnancy\n* Simultaneous participation to another interventionnal study","ALL","18 Years",{"count":64,"type":65},152,"ESTIMATED","INTERVENTIONAL",[68],"NA","The main objective is to demonstrate that dTMS is more efficient than high frequency rTMS with a conventional coil.\n\nThe patient will receive treatment arm A or B :\n\nArm A : classic rTMS treatment (use of the 8-shaped coil) and standard therapy Arm B: treatment with deep rTMS (use of the H-shaped coil (helmet)) and standard therapies.\n\n20 rTMS sessions are planned (5 sessions per week) and 3 follow-up visits : at Day 30, Day 60 and Day 90.",[71],"Depressive Disorder, Treatment-Resistant","2026-01-12",{"date":74,"type":75},"2026-01-13","ACTUAL",{"date":77,"type":75},"2021-08-23",{"date":79,"type":65},"2028-08",{"name":5,"class":6},1]