[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100637298":3},{"organization":4,"outcomesModule":7,"designInfo":26,"detailedDescription":25,"studyPopulation":25,"armGroups":37,"interventions":50,"overallOfficials":58,"centralContacts":63,"locations":72,"responsibleParty":83,"collaborators":25,"id":85,"slug":25,"hasResults":86,"nctId":87,"briefTitle":88,"officialTitle":89,"acronym":25,"eligibilityCriteria":90,"healthyVolunteers":91,"sex":92,"minAge":93,"maxAge":94,"enrollmentInfo":95,"targetDuration":25,"studyType":98,"phases":99,"briefSummary":101,"conditions":102,"keywords":25,"overallStatus":75,"whyStopped":25,"lastUpdateSubmitDate":104,"lastUpdatePostDateStruct":105,"startDateStruct":108,"completionDateStruct":110,"leadSponsor":112,"locationsCount":113},{"fullName":5,"class":6},"Burapha University","OTHER",{"primaryOutcomes":8,"secondaryOutcomes":20,"otherOutcomes":25},[9,13,17],{"measure":10,"description":11,"timeFrame":12},"Concentrations of blood glucose","Concentrations of blood glucose were measured before and after MMC capsules or calamansi capsule consumption at 500 mg in mg\u002FdL unit","At 0 minute before consumption, at 30, 60, 90, 120 minutes after consumption, and at days 91 after consumption",{"measure":14,"description":15,"timeFrame":16},"Concentrations of blood insulin","Concentrations of blood insulin were measured before and after MMC capsules or calamansi capsule consumption at 500 mg in uU\u002FmL (microunit\u002Fmilliliter) unit","At 0 minute before consumption, at 120 minute after consumption, and at days 91 after consumption",{"measure":18,"description":19,"timeFrame":16},"Concentrations of blood malondialdehyde","Concentrations of blood malondialdehyde were measured before and after MMC capsules or calamansi capsule consumption at 500 mg in uM (micromolar) unit",[21],{"measure":22,"description":23,"timeFrame":24},"Levels of heart rate variability","Heart rate variability were measured before and after MMC capsules or calamansi capsule consumption at 500 mg in ms (milliseconds) and ms2 (millisecond squared) unit","At 0-10 minutes before consumption, at 110-120 minutes after consumption, and at days 91 after consumption for 10 minutes",null,{"allocation":27,"interventionModel":28,"interventionModelDescription":29,"primaryPurpose":30,"observationalModel":25,"timePerspective":25,"maskingInfo":31},"RANDOMIZED","PARALLEL","Participants will be randomly divided into 2 groups consisting of placebo group (n = 27) or a treatment group (n = 27).","PREVENTION",{"masking":32,"maskingDescription":25,"whoMasked":33},"TRIPLE",[34,35,36],"PARTICIPANT","INVESTIGATOR","OUTCOMES_ASSESSOR",[38,44],{"label":39,"type":40,"description":41,"interventionNames":42},"MMC powder capsule","PLACEBO_COMPARATOR","Participants will be randomly assigned to an intervention arm. During the short-term phase, participants in the control group will receive microcrystalline cellulose (MMC) capsules and will be instructed to consume 1,500 mg\u002Fday (three capsules). During the long-term phase, participants will continue consuming MMC at a dose of 1,500 mg\u002Fday (three capsules), taken within 15-30 min after breakfast. All supplementation will be administered at the participants' residences.",[43],"Other: MMC powder capsule",{"label":45,"type":46,"description":47,"interventionNames":48},"Calamansi powder capsule","EXPERIMENTAL","Participants will be randomly assigned to an intervention arm. During the short-term phase, participants in the calamansi group will receive calamansi powder capsules and will be instructed to consume 1,500 mg\u002Fday (three capsules). During the long-term phase, participants will continue consuming calamansi powder capsules at a dose of 1,500 mg\u002Fday (three capsules), taken within 15-30 min after breakfast. All supplementation will be administered at the participants' residences.",[49],"Dietary Supplement: Calamansi powder capsule",[51,54],{"type":6,"name":39,"description":52,"armGroupLabels":53,"otherNames":25},"Each capsule contains MMC powder for 500 mg",[39],{"type":55,"name":45,"description":56,"armGroupLabels":57,"otherNames":25},"DIETARY_SUPPLEMENT","Each capsule contains calamansi powder for 500 mg",[45],[59],{"name":60,"affiliation":61,"role":62},"Piyapong Prasertsri, Ph.D.","Faculty of Allied Health Sciences, Burapha University","PRINCIPAL_INVESTIGATOR",[64,68],{"name":60,"role":65,"phone":66,"phoneExt":25,"email":67},"CONTACT","6638103166","piyapong@buu.ac.th",{"name":69,"role":65,"phone":70,"phoneExt":25,"email":71},"Kulwara Poolpol, Ph.D.","6638103147","kulwara@go.buu.ac.th",[73],{"facility":74,"status":75,"city":76,"state":5,"zip":77,"country":78,"countryCode":79,"cosmosGeoPoint":25,"geoPoint":25,"contacts":80},"Piyapong Prasertsri","RECRUITING","Mueang","20131","Thailand","TH",[81,82],{"name":60,"role":65,"phone":66,"phoneExt":25,"email":67},{"name":69,"role":65,"phone":70,"phoneExt":25,"email":71},{"type":62,"investigatorFullName":74,"investigatorTitle":84,"investigatorAffiliation":5,"oldNameTitle":25,"oldOrganization":25},"Associate Professor Dr.","100637298",false,"NCT07587905","Effects of Calamansi on Blood Glucose and Insulin Levels","The Effects of Calamansi (Citrus x Macrocarpa Bunge) Supplementation on Blood Glucose and Insulin Levels in Healthy Volunteers","Inclusion Criteria:\n\n* Healthy individuals who have not been diagnosed with diabetes or prediabetes, with a fasting blood glucose level (after 8 hours of fasting) of less than 100 mg\u002FdL.\n* Aged between 18-30 years, both male and female\n* Body Mass Index (BMI) between 18.5 and 22.9 kg\u002Fm²\n* No diseases affecting blood sugar levels, such as liver or pancreatic diseases\n\nExclusion Criteria:\n\n* Pregnant or breastfeeding women\n* Regular smokers\n* Regular alcohol consumers\n* Individuals with a history of allergies to citrus fruits or citrus-derived ingredients\n* Individuals taking medications that affect glucose metabolism and fat distribution in the body, including steroids, protease inhibitors, and psychiatric medications. These refer to drugs that act on the central nervous system and may affect blood sugar levels or energy metabolism, such as antidepressants, antipsychotics, and mood stabilizers.",true,"ALL","18 Years","30 Years",{"count":96,"type":97},54,"ESTIMATED","INTERVENTIONAL",[100],"NA","Fifty-four healthy sedentary male and female participants aged 18-30 years will be recruited for this study. Participants will be randomly assigned to one of two groups: a control group receiving placebo MMC capsules (n = 27) or a calamansi capsule supplementation group (n = 27). All participants will undergo health screening procedures, including medical history assessment, mental health questionnaire evaluation, and measurements of vital signs, height, body weight, and body composition. Venous blood samples will subsequently be collected to determine blood glucose, insulin, creatinine, alanine aminotransferase (ALT), and malondialdehyde (MDA) levels. These assessments will be performed at three time points: 1) before capsule supplementation (baseline), 2) following a single dose of capsule supplementation, and 3) after 12 weeks of supplementation.",[103],"Calamansi Powder Capsule Supplementation","2026-05-13",{"date":106,"type":107},"2026-05-15","ACTUAL",{"date":109,"type":107},"2026-05-01",{"date":111,"type":97},"2027-01-31",{"name":5,"class":6},1]