[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100637233":3},{"organization":4,"outcomesModule":7,"designInfo":26,"detailedDescription":16,"studyPopulation":16,"armGroups":35,"interventions":48,"overallOfficials":16,"centralContacts":56,"locations":62,"responsibleParty":79,"collaborators":16,"id":82,"slug":16,"hasResults":83,"nctId":84,"briefTitle":85,"officialTitle":86,"acronym":16,"eligibilityCriteria":87,"healthyVolunteers":83,"sex":88,"minAge":89,"maxAge":90,"enrollmentInfo":91,"targetDuration":16,"studyType":94,"phases":95,"briefSummary":97,"conditions":98,"keywords":101,"overallStatus":65,"whyStopped":16,"lastUpdateSubmitDate":108,"lastUpdatePostDateStruct":109,"startDateStruct":112,"completionDateStruct":114,"leadSponsor":116,"locationsCount":117},{"fullName":5,"class":6},"Sun Yat-sen University","OTHER",{"primaryOutcomes":8,"secondaryOutcomes":13,"otherOutcomes":16},[9],{"measure":10,"description":11,"timeFrame":12},"overall PICC-related complications after catheter placement","these complications include catheter exit site oozing, contact dermatitis, venous thrombosis, infection, catheter displacement or dislodgement, mechanical phlebitis, catheter occlusion, and catheter fracture or damage.","4 weeks after PICC placement",[14,18,22,24],{"measure":15,"description":16,"timeFrame":17},"first-puncture success rate of PICC catheterization",null,"day 1 during PICC catheterization",{"measure":19,"description":20,"timeFrame":21},"pain score","Evaluated by Numerical Rating Scale , a self-report tool where individuals rate their pain intensity from 0 (no pain) to 10 (worst possible pain)，with higher scores indicating more severe pain.","Day 1 during PICC placement",{"measure":23,"description":16,"timeFrame":21},"Bleeding during PICC placement",{"measure":25,"description":16,"timeFrame":12},"unplanned catheter removal rate of PICC",{"allocation":27,"interventionModel":28,"interventionModelDescription":16,"primaryPurpose":6,"observationalModel":16,"timePerspective":16,"maskingInfo":29},"RANDOMIZED","PARALLEL",{"masking":30,"maskingDescription":16,"whoMasked":31},"TRIPLE",[32,33,34],"CARE_PROVIDER","INVESTIGATOR","OUTCOMES_ASSESSOR",[36,42],{"label":37,"type":38,"description":39,"interventionNames":40},"cancer patients who undergo PICC placement using two-needle tunnel technique","ACTIVE_COMPARATOR","Two-needle tunnel PICC procedure:\n\n1. Local anesthesia at puncture and catheter exit sites;\n2. Ultrasound-guided vascular puncture at puncture site, guide wire inserted via puncture needle;\n3. Skin dilation at both puncture and exit sites;\n4. 4cm saline tunnel created with 0.9% NaCl: 10mL syringe advanced along tunnel path while injecting solution;\n5. Subcutaneous tunnel formed from exit site to puncture site with tunneling tool, catheter pulled through tunnel to puncture site;\n6. Vascular sheath inserted over guide wire, catheter trimmed to length, advanced through sheath after guide wire removal;\n7. Vascular sheath peeled off, catheter adjusted to proper position;\n8. Catheter tip position confirmed;\n9. Puncture site closed with suture-free tape, both sites covered with sterile dressings, catheter secured.",[41],"Other: two-needle tunnel technique",{"label":43,"type":44,"description":45,"interventionNames":46},"cancer patients who undergo PICC placement using one-needle tunnel technique","EXPERIMENTAL","Ultrasound guidance is used for vascular puncture and assisted subcutaneous tunnel creation:\n\n1. Local anesthesia is administered at the puncture site，the puncture needle travels 4 cm through the subcutaneous tissue before entering the blood vessel;\n2. The guide wire is inserted along the puncture needle;\n3. skin dilation;\n4. The vascular sheath is advanced into the blood vessel via the guide wire, and the catheter is inserted through the vascular sheath;\n5. The catheter tip position is confirmed, and the catheter is secured.",[47],"Other: One-needle tunnel technique",[49,53],{"type":6,"name":50,"description":51,"armGroupLabels":52,"otherNames":16},"One-needle tunnel technique","1. Local anesthesia is administered at the puncture site，Ultrasound guidance is used for vascular puncture and assisted subcutaneous tunnel creation，the puncture needle travels 4 cm through the subcutaneous tissue before entering the blood vessel;\n2. The guide wire is inserted along the puncture needle;\n3. skin dilation;\n4. The vascular sheath is advanced into the blood vessel via the guide wire, and the catheter is inserted through the vascular sheath;\n5. The catheter tip position is confirmed, and the catheter is secured.",[43],{"type":6,"name":54,"description":39,"armGroupLabels":55,"otherNames":16},"two-needle tunnel technique",[37],[57],{"name":58,"role":59,"phone":60,"phoneExt":16,"email":61},"Zeyin Hu","CONTACT","15899954190","huzy@sysucc.org.cn",[63],{"facility":64,"status":65,"city":66,"state":67,"zip":68,"country":69,"countryCode":70,"cosmosGeoPoint":71,"geoPoint":76,"contacts":77},"Sun Yat-sen University Cancer Center","RECRUITING","Guangzhou","Guangdong","510000","China","CN",{"type":72,"coordinates":73},"Point",[74,75],113.25,23.11667,{"lat":75,"lon":74},[78],{"name":58,"role":59,"phone":60,"phoneExt":16,"email":61},{"type":80,"investigatorFullName":58,"investigatorTitle":81,"investigatorAffiliation":5,"oldNameTitle":16,"oldOrganization":16},"PRINCIPAL_INVESTIGATOR","Specialist Nurse","100637233",false,"NCT07594704","Effects of Different Tunnel Methods in PICC Catheterization","Effects of Different Tunnel Methods in PICC Catheterization: A Randomized Controlled Trial","Inclusion Criteria:\n\n* Aged between 18 and 75 years old;\n* Educational level of primary school or above, with basic listening, speaking, reading and writing abilities, and capable of completing the questionnaire independently;\n* Receiving tunneled PICC catheterization for the first time, with 4Fr single-lumen solo PICC catheter indwelling;\n* Able to attend regular PICC maintenance at our hospital as scheduled after catheterization;\n* Voluntarily participate in this study and sign the informed consent form for this study as well as the informed consent form for PICC catheterization.\n\nExclusion Criteria:\n\n* Patients with coagulation dysfunction (INR \\> 1.5 \u002F PLT \\\u003C 50×10⁹\u002FL);\n* Pregnant or lactating women;\n* Patients with BMI \\\u003C 18.5 kg\u002Fm²;\n* Patients receiving PICC catheterization via lower extremity veins;\n* Patients with known or suspected allergy to components of PICC catheters.","ALL","18 Years","75 Years",{"count":92,"type":93},284,"ESTIMATED","INTERVENTIONAL",[96],"NA","This prospective randomized controlled trial compares the effectiveness and safety of one-needle and two-needle tunneling techniques for peripherally inserted central catheter (PICC) placement, aiming to identify the optimal tunneling method to reduce catheter-related complications.",[99,100],"PICC Line Placement","PICC-associated Thrombosis",[102,103,104,105,106,107],"tunnel","PICC","complications","thrombosis","infection","bleeding","2026-05-18",{"date":110,"type":111},"2026-05-22","ACTUAL",{"date":113,"type":111},"2026-04-01",{"date":115,"type":93},"2026-07-30",{"name":5,"class":6},1]