[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100637727":3},{"organization":4,"outcomesModule":7,"designInfo":29,"detailedDescription":31,"studyPopulation":32,"armGroups":28,"interventions":33,"overallOfficials":28,"centralContacts":43,"locations":50,"responsibleParty":70,"collaborators":72,"id":76,"slug":28,"hasResults":77,"nctId":78,"briefTitle":79,"officialTitle":80,"acronym":81,"eligibilityCriteria":82,"healthyVolunteers":77,"sex":83,"minAge":84,"maxAge":28,"enrollmentInfo":85,"targetDuration":28,"studyType":88,"phases":28,"briefSummary":89,"conditions":90,"keywords":28,"overallStatus":53,"whyStopped":28,"lastUpdateSubmitDate":93,"lastUpdatePostDateStruct":94,"startDateStruct":97,"completionDateStruct":99,"leadSponsor":101,"locationsCount":102},{"fullName":5,"class":6},"Prisma Health-Upstate","OTHER",{"primaryOutcomes":8,"secondaryOutcomes":28,"otherOutcomes":28},[9,13,16,19,22,25],{"measure":10,"description":11,"timeFrame":12},"Perceived Sweetness","Perceived sweetness of each e-cigarette flavor will be assessed using a one-item VAS ranging from \"Not sweet at all\" to \"Extremely sweet,\" with higher scores indicating greater perceived sweetness.","Baseline session",{"measure":14,"description":15,"timeFrame":12},"Perceived Coolness\u002FFreshness","Perceived coolness\u002Ffreshness of each e-cigarette flavor will be assessed using a one-item VAS ranging from \"Not cool\u002Ffresh at all\" to \"Extremely cool\u002Ffresh,\" with higher scores indicating greater perceived coolness\u002Ffreshness.",{"measure":17,"description":18,"timeFrame":12},"Perceived Flavor Strength","Perceived flavor strength will be assessed using a one-item VAS ranging from \"Very weak\" to \"Very strong,\" with higher scores indicating greater perceived flavor strength.",{"measure":20,"description":21,"timeFrame":12},"Perceived Harshness\u002FIrritation","Perceived harshness\u002Firritation of each e-cigarette flavor will be assessed using a one-item VAS ranging from \"Not harsh\u002Firritating at all\" to \"Extremely harsh\u002Firritating,\" with higher scores indicating greater perceived harshness\u002Firritation.",{"measure":23,"description":24,"timeFrame":12},"Flavor Liking","Flavor liking will be assessed using a one-item VAS ranging from \"Not at all\" to \"Extremely,\" with higher scores indicating greater liking of the flavor.",{"measure":26,"description":27,"timeFrame":12},"Likelihood of Future Use","Likelihood of future use will be assessed using a one-item VAS ranging from \"Not at all\" to \"Definitely,\" with higher scores indicating greater likelihood of future use of the flavor.",null,{"allocation":28,"interventionModel":28,"interventionModelDescription":28,"primaryPurpose":28,"observationalModel":6,"timePerspective":30,"maskingInfo":28},"PROSPECTIVE","This study examines the effects of e-cigarette (EC) flavors among adults with opioid use disorder (OUD) who are receiving buprenorphine treatment and currently use e-cigarettes. Participants will complete a brief session in which they will smell and rate 11 EC flavors based on their appeal, sensory characteristics, and likelihood of future use. Researchers will examine how different flavor profiles influence the appeal, positive subjective effects, and reinforcing potential of EC flavors in this population. The goal of the study is to identify one or more EC flavors that may enhance the acceptability and reinforcing effects of ECs as a potential harm-reduction strategy among adults with OUD receiving buprenorphine treatment.","E-cigarette users with opioid use disorder receiving burpenorphine",[34,38,41],{"type":35,"name":36,"description":37,"armGroupLabels":28,"otherNames":28},"DRUG","Sweet-cooling","Sweet-cooling EC flavor",{"type":35,"name":39,"description":40,"armGroupLabels":28,"otherNames":28},"Sweet non-cooling EC flavor","Sweet non-cooling flavor",{"type":35,"name":42,"description":42,"armGroupLabels":28,"otherNames":28},"Tobacco flavor EC",[44],{"name":45,"role":46,"phone":47,"phoneExt":48,"email":49},"Irene Pericot-Valverde, PhD","CONTACT","18549998005","(864)656-4467","iperico@clemson.edu",[51],{"facility":52,"status":53,"city":54,"state":55,"zip":56,"country":57,"countryCode":58,"cosmosGeoPoint":59,"geoPoint":64,"contacts":65},"Prisma Health Recovery Clinic-Greenville","RECRUITING","Greenville","South Carolina","29605","United States","US",{"type":60,"coordinates":61},"Point",[62,63],-82.39401,34.85262,{"lat":63,"lon":62},[66],{"name":67,"role":46,"phone":68,"phoneExt":28,"email":69},"Alain Litwin, MD","(864) 455-5994","alain.litwin@prismahealth.org",{"type":71,"investigatorFullName":28,"investigatorTitle":28,"investigatorAffiliation":28,"oldNameTitle":28,"oldOrganization":28},"SPONSOR",[73],{"name":74,"class":75},"National Institute on Drug Abuse (NIDA)","NIH","100637727",false,"NCT07594717","Effects of E-Cigarette Flavors on Adult E-Cigarette Users With Opioid Use Disorder","Effects of E-Cigarette Flavors on Adult E-Cigarette Users With Opioid Use Disorder Receiving Buprenorphine","FLAVOR","Inclusion Criteria:\n\n* Adults aged 21 years or older.\n* Current e-cigarette users who report e-cigarette use on ≥20 of the past 30 days.\n* Former daily cigarette smokers who currently smoke on ≤19 days per month and no more than 5 cigarettes per day.\n* Diagnosed with opioid use disorder (OUD).\n* Currently receiving buprenorphine treatment for OUD.\n\nExclusion Criteria:\n\n\\-","ALL","21 Years",{"count":86,"type":87},70,"ESTIMATED","OBSERVATIONAL","This study examines the effects of e-cigarette (EC) flavors among adults with opioid use disorder (OUD) receiving buprenorphine treatment who currently use e-cigarettes. Participants will smell and rate 11 EC flavors based on appeal, sensory characteristics, and likelihood of future use. Researchers will examine how different flavor profiles influence the appeal and reinforcing effects of ECs in this population. The goal is to identify EC flavors that may enhance the acceptability of ECs as a potential harm-reduction strategy among adults with OUD receiving buprenorphine treatment.",[91,92],"Nicotine Use Disoder","Opioid Use Disorder","2026-05-19",{"date":95,"type":96},"2026-05-22","ACTUAL",{"date":98,"type":96},"2025-11-12",{"date":100,"type":87},"2026-05",{"name":5,"class":6},1]