[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100598572":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":34,"centralContacts":39,"locations":44,"responsibleParty":59,"collaborators":62,"id":65,"slug":33,"hasResults":66,"nctId":67,"briefTitle":68,"officialTitle":69,"acronym":70,"eligibilityCriteria":71,"healthyVolunteers":66,"sex":72,"minAge":73,"maxAge":33,"enrollmentInfo":74,"targetDuration":33,"studyType":77,"phases":78,"briefSummary":80,"conditions":81,"keywords":87,"overallStatus":47,"whyStopped":33,"lastUpdateSubmitDate":96,"lastUpdatePostDateStruct":97,"startDateStruct":100,"completionDateStruct":102,"leadSponsor":104,"locationsCount":105},{"fullName":5,"class":6},"Danderyd Hospital","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Contralesional cerebellum iTBS and conventional rehabilitation","EXPERIMENTAL","The experimental group will receive intermittent theta burst stimulation on the contralesional cerebellum followed by 45 minutes of conventional rehabilitation interventions involving the lower extremity led or instructed by a physiotherapist.",[13],"Device: Intermittent Theta Burst Stimulation",{"label":15,"type":16,"description":17,"interventionNames":18},"Contralesional cerebellum sham-iTBS and conventional rehabilitation","SHAM_COMPARATOR","The placebo group will get sham intermittent theta burst stimulation on the contralesional cerebellum followed by 45 minutes of conventional rehabilitation interventions involving the lower extremity led or instructed by a physiotherapist.",[19],"Device: Sham Intermittent Theta Burst Stimulation",[21,29],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"DEVICE","Intermittent Theta Burst Stimulation","iTBS protocol: 600 pulses at 80% of AMT for 190 sec on the contralesional cerebellum, targeted with the support of a neuronavigational system, 15 sessions over a period of 5 weeks",[9],[27,28],"iTBS","TMS",{"type":22,"name":30,"description":31,"armGroupLabels":32,"otherNames":33},"Sham Intermittent Theta Burst Stimulation","It is identical to its active version, replicates operational sounds, and delivers a very shallow magnetic field to mimic the sensation of magnetic stimulation.",[15],null,[35],{"name":36,"affiliation":37,"role":38},"Susanne Palmcrantz, PhD, Associate Professor","Dep of Clinical Sciences, Karolinska Institutet","PRINCIPAL_INVESTIGATOR",[40],{"name":36,"role":41,"phone":42,"phoneExt":33,"email":43},"CONTACT","004681235000","susanne.palmcrantz@ki.se",[45],{"facility":46,"status":47,"city":48,"state":33,"zip":33,"country":49,"cosmosGeoPoint":50,"geoPoint":55,"contacts":56},"Department of Rehabilitation Medicine, Danderyd Hospital, Danderyd, Stockholm 18288","RECRUITING","Stockholm","Sweden",{"type":51,"coordinates":52},"Point",[53,54],18.06871,59.32938,{"lat":54,"lon":53},[57],{"name":58,"role":41,"phone":42,"phoneExt":33,"email":43},"Susanne Palmcrantz, PhD",{"type":38,"investigatorFullName":60,"investigatorTitle":61,"investigatorAffiliation":5,"oldNameTitle":33,"oldOrganization":33},"Susanne Palmcrantz","PhD, Associate Professor, Reg Physiotherapist",[63],{"name":64,"class":6},"Karolinska Institutet","100598572",false,"NCT07073235","Effects of Intermittent Theta Burst Stimulation (iTBS) on Motor Recovery of Lower Extremity in Chronic Stroke Patients","Neuroplastic Changes and Effects of Intermittent Theta Burst Stimulation (iTBS) on Motor Recovery of Upper and Lower Extremity in Chronic Stroke Patients","NIMBLE","Inclusion Criteria:\n\n* Age over 18\n* Chronic stroke (\\>6 months)\n* Residual hemiparesis FAC ≥3\n\nExclusion Criteria:\n\n* Metal implants\n* Epilepsy\u002Fseizures\n* Pregnancy\n* Claustrophobia (related to MRIs exams)\n* Severe cognitive impairment\n* Untreated or unstable depression\u002Fanxiety\n* Other disabilities prohibiting intensive physical training","ALL","18 Years",{"count":75,"type":76},56,"ESTIMATED","INTERVENTIONAL",[79],"NA","This study aims to evaluate the effects and clinical feasibility of non-invasive brain stimulation protocols, specifically intermittent Theta Burst Stimulation, as part of rehabilitation interventions for motor recovery of lower extremity in the chronic phase after stroke.\n\nIt also seeks to explore the underlying mechanisms by investigating changes of functional and structural brain networks.",[82,83,84,85,86],"Stroke","Hemiparesis After Stroke","Chronic Stroke Patients","Hemiplegia","Ambulatory Difficulty",[88,27,28,89,90,91,92,93,94,95],"stroke","Trancranial Magnetic Stimulation","Cerebellum","Chronic stroke patients","Balance","Walking","Hemiparesis","intermittent Theta Burst Stimulation","2025-11-20",{"date":98,"type":99},"2025-11-25","ACTUAL",{"date":101,"type":76},"2025-11",{"date":103,"type":76},"2030-12",{"name":5,"class":6},1]