[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100577815":3},{"organization":4,"outcomesModule":7,"designInfo":23,"detailedDescription":29,"studyPopulation":22,"armGroups":30,"interventions":42,"overallOfficials":52,"centralContacts":56,"locations":62,"responsibleParty":80,"collaborators":22,"id":83,"slug":22,"hasResults":84,"nctId":85,"briefTitle":86,"officialTitle":87,"acronym":22,"eligibilityCriteria":88,"healthyVolunteers":84,"sex":89,"minAge":90,"maxAge":91,"enrollmentInfo":92,"targetDuration":22,"studyType":95,"phases":96,"briefSummary":98,"conditions":99,"keywords":22,"overallStatus":65,"whyStopped":22,"lastUpdateSubmitDate":101,"lastUpdatePostDateStruct":102,"startDateStruct":105,"completionDateStruct":107,"leadSponsor":109,"locationsCount":110},{"fullName":5,"class":6},"Kaohsiung Veterans General Hospital.","OTHER",{"primaryOutcomes":8,"secondaryOutcomes":16,"otherOutcomes":22},[9,13],{"measure":10,"description":11,"timeFrame":12},"oxygen consumption rate of mitochodria (%)","to assess mitocondrial function in cumulus cells","through study completion, an average of 3 year",{"measure":14,"description":15,"timeFrame":12},"Live birth rate (%)","a viable infant after 24 weeks of gestation",[17,19],{"measure":18,"description":11,"timeFrame":12},"Amount of ATP production (moles\u002Fmin) of mitochodria",{"measure":20,"description":21,"timeFrame":12},"Clinical pregnancy rate (%)","the presence of a fetal heartbeat detected via transvaginal sonography at 6-7 weeks of gestation",null,{"allocation":24,"interventionModel":25,"interventionModelDescription":22,"primaryPurpose":26,"observationalModel":22,"timePerspective":22,"maskingInfo":27},"NON_RANDOMIZED","PARALLEL","TREATMENT",{"masking":28,"maskingDescription":22,"whoMasked":22},"NONE","The impact of combined follicle-stimulating hormone (FSH) and luteinizing hormone (LH) treatment on ovulation stimulation in older infertile women has garnered significant attention in reproductive medicine. While research indicates improved in vitro fertilization (IVF) pregnancy rates in women aged 35-40 receiving combined FSH and LH therapy compared to FSH alone, the underlying mechanisms and effectiveness remain unclear. This prospective study aims to investigate the effects of combined FSH and LH treatment on cumulus cell energy metabolism in infertile women aged 35-40 undergoing IVF treatment. The research will involve 60 participants divided into two equal groups: one receiving combined FSH and LH therapy and the other receiving FSH alone. The study will collect comprehensive data including baseline characteristics, infertility history, ovarian function parameters, and ovulation stimulation cycle outcomes. Additionally, cumulus cells will be collected from both groups to compare their mitochondrial metabolic function. Through this investigation, we seek to understand whether the combined hormone approach can enhance cumulus cell energy metabolism and improve overall ovulation stimulation outcomes in this specific age group. CopyRetryClaude can make mistakes. Please double-check responses.",[31,37],{"label":32,"type":33,"description":34,"interventionNames":35},"combined FSH and LH","EXPERIMENTAL","Participants receive combined FSH and LH during controlled ovarian stimulation in IVF cycle",[36],"Drug: FSH and LH",{"label":38,"type":39,"description":34,"interventionNames":40},"FSH alone","ACTIVE_COMPARATOR",[41],"Drug: FSH",[43,48],{"type":44,"name":45,"description":46,"armGroupLabels":47,"otherNames":22},"DRUG","FSH and LH","In the study group, participants receive FSH and LH in IVF cycle",[32],{"type":44,"name":49,"description":50,"armGroupLabels":51,"otherNames":22},"FSH","In the control group, participants receive FSH alone in IVF cycle",[38],[53],{"name":54,"affiliation":5,"role":55},"Kuan-Hao Tsui","STUDY_CHAIR",[57],{"name":58,"role":59,"phone":60,"phoneExt":22,"email":61},"Li-Te Lin","CONTACT","+88673464027","litelin1982@gmail.com",[63],{"facility":64,"status":65,"city":66,"state":22,"zip":67,"country":68,"countryCode":69,"cosmosGeoPoint":70,"geoPoint":75,"contacts":76},"Kaohsiung Veterans General Hospital","RECRUITING","Kaohsiung City","81362","Taiwan","TW",{"type":71,"coordinates":72},"Point",[73,74],120.31333,22.61626,{"lat":74,"lon":73},[77,78],{"name":58,"role":59,"phone":60,"phoneExt":22,"email":61},{"name":54,"role":59,"phone":79,"phoneExt":22,"email":22},"+886-7-3422121",{"type":81,"investigatorFullName":58,"investigatorTitle":82,"investigatorAffiliation":5,"oldNameTitle":22,"oldOrganization":22},"PRINCIPAL_INVESTIGATOR","Attending doctor, Department of Obstetrics and Gynecology","100577815",false,"NCT06803199","Effects of LH and FSH on Metabolic Regulation in Cumulus Cells","Investigation of the Combined Effects of Luteinizing Hormone and Follicle-Stimulating Hormone on Metabolic Regulation in Cumulus Cells","Inclusion Criteria:\n\n* Age 35-40 years\n* BMI 18-30 kg\u002Fm2\n* planning to undergo IVF cycles\n\nExclusion Criteria:\n\n* Primary ovarian insufficiency\n* history of oophorectomy\n* receiving oocyte donation\n* Chromosome anomaly\n* Congenital uterine anomaly\n* Severe intrauterine adhesion\n* Malignancy\n* Using hormone therapy or supplements in recent 3 months","FEMALE","35 Years","40 Years",{"count":93,"type":94},60,"ESTIMATED","INTERVENTIONAL",[97],"NA","The combined use of follicle-stimulating hormone (FSH) and luteinizing hormone (LH) has improved IVF pregnancy rates in infertile women aged 35-40, but its mechanisms remain unclear. This prospective study will examine how FSH and LH combined treatment affects cumulus cell energy metabolism. Sixty participants will be divided into two groups receiving either combined therapy or FSH alone. The study will analyze patient characteristics, infertility history, and compare mitochondrial function in cumulus cells to evaluate treatment effectiveness.",[100],"Unrecognized Condition","2025-01-27",{"date":103,"type":104},"2025-01-31","ACTUAL",{"date":106,"type":104},"2024-12-01",{"date":108,"type":94},"2027-12-31",{"name":5,"class":6},1]