[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100521628":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":11,"centralContacts":19,"locations":28,"responsibleParty":48,"collaborators":11,"id":50,"slug":11,"hasResults":51,"nctId":52,"briefTitle":53,"officialTitle":54,"acronym":11,"eligibilityCriteria":55,"healthyVolunteers":56,"sex":57,"minAge":58,"maxAge":59,"enrollmentInfo":60,"targetDuration":11,"studyType":63,"phases":64,"briefSummary":66,"conditions":67,"keywords":70,"overallStatus":31,"whyStopped":11,"lastUpdateSubmitDate":73,"lastUpdatePostDateStruct":74,"startDateStruct":77,"completionDateStruct":79,"leadSponsor":81,"locationsCount":82},{"fullName":5,"class":6},"Integrative Skin Science and Research","INDUSTRY",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"Skin Barrier Oral Supplement","EXPERIMENTAL",null,[13],"Dietary Supplement: Skin Barrier Oral Supplement",[15],{"type":16,"name":9,"description":17,"armGroupLabels":18,"otherNames":11},"DIETARY_SUPPLEMENT","Supplment powder",[9],[20,25],{"name":21,"role":22,"phone":23,"phoneExt":11,"email":24},"Caitlin Egli","CONTACT","916-750-2463","research@integrativeskinresearch.com",{"name":26,"role":22,"phone":11,"phoneExt":11,"email":27},"Milred Min","milred@integrativeskinresearch.com",[29],{"facility":30,"status":31,"city":32,"state":33,"zip":34,"country":35,"cosmosGeoPoint":36,"geoPoint":41,"contacts":42},"Integrative Skin and Research","RECRUITING","Sacramento","California","95815","United States",{"type":37,"coordinates":38},"Point",[39,40],-121.4944,38.58157,{"lat":40,"lon":39},[43,45],{"name":44,"role":22,"phone":23,"phoneExt":11,"email":24},"Raja Sivamani, MD, MS, AP",{"name":46,"role":47,"phone":11,"phoneExt":11,"email":11},"Raja Sivamani, MD MS AP","PRINCIPAL_INVESTIGATOR",{"type":49,"investigatorFullName":11,"investigatorTitle":11,"investigatorAffiliation":11,"oldNameTitle":11,"oldOrganization":11},"SPONSOR","100521628",false,"NCT06072066","Effects of Oral Supplement Containing L-Histidine and Antioxidants on the Skin Barrier Function and Systemic Inflammation in Rosacea","The Effects of Oral Supplement Containing L-Histidine and Antioxidants on the Skin Barrier Function and Systemic Inflammation in Rosacea","Inclusion Criteria:\n\n* Males and females 30 to 70 years of age\n* The presence of mild to moderate rosacea (erythematotelangiectatic or papulopustular)\n* High sensitivity C-reactive protein (hs-CRP) that is greater than or equal to 1.0 mg\u002FL\n\nExclusion Criteria:\n\n* The presence of severe rosacea as noted by the investigator global assessment.\n* Those who are unwilling to discontinue oral supplementation, or supplement ingredients found in the study's oral product 1 month prior to enrollment.\n* Discontinuation of oral L-glutamine or L-glutamine containing supplement 1 month prior to enrollment\n* Those who are unwilling to discontinue topical benzoyl peroxide or retinoids for 2 weeks prior to enrollment.\n* Those who are unwilling to keep their facial regimen the same throughout the study.\n* Individuals who have been on an oral antibiotic within the previous one month.\n* Individuals who are pregnant or breastfeeding.\n* Individuals who have changed any of their hormonal based contraception or therapies within 3 months prior to joining the study.\n* Individuals on oral contraceptive pills or progesterone or estrogen containing therapies.\n* Use of isotretinoin within the three months prior to enrollment.\n* Individuals on finasteride or dutasteride\n* Current tobacco smoker, smoker within the past year, or greater than 5 pack-year tobacco smoking history.",true,"ALL","30 Years","70 Years",{"count":61,"type":62},24,"ESTIMATED","INTERVENTIONAL",[65],"NA","The purpose of this study is to evaluate how supplementation will alter the skin and the gut barrier and inflammation in those with rosacea.",[68,69],"Rosacea","Systemic Inflammation",[68,71,72],"L-Histidine","Antioxidants","2024-08-26",{"date":75,"type":76},"2024-08-27","ACTUAL",{"date":78,"type":76},"2023-11-22",{"date":80,"type":62},"2024-12-31",{"name":5,"class":6},1]