[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100639653":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":28,"centralContacts":32,"locations":38,"responsibleParty":57,"collaborators":25,"id":59,"slug":25,"hasResults":60,"nctId":61,"briefTitle":62,"officialTitle":62,"acronym":25,"eligibilityCriteria":63,"healthyVolunteers":60,"sex":64,"minAge":65,"maxAge":66,"enrollmentInfo":67,"targetDuration":25,"studyType":70,"phases":71,"briefSummary":73,"conditions":74,"keywords":77,"overallStatus":41,"whyStopped":25,"lastUpdateSubmitDate":83,"lastUpdatePostDateStruct":84,"startDateStruct":87,"completionDateStruct":89,"leadSponsor":91,"locationsCount":92},{"fullName":5,"class":6},"Universidade Federal Fluminense","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Royal Jelly + Propolis Group","EXPERIMENTAL","Participants will receive 4 capsules per day, providing the dosage of 300mg of royal jelly + 500mg propolis for 2 months (8 weeks).",[13],"Dietary Supplement: Royal Jelly + Propolis Group",{"label":15,"type":16,"description":17,"interventionNames":18},"Placebo Group","PLACEBO_COMPARATOR","The placebo group will receive 4 capsules per day (containing microcrystalline cellulose and magnesium stearate in colored gelatin capsules capable of masking the appearance of the internal content), at the same time for 2 months.",[19],"Dietary Supplement: Placebo",[21,26],{"type":22,"name":23,"description":17,"armGroupLabels":24,"otherNames":25},"DIETARY_SUPPLEMENT","Placebo",[15],null,{"type":22,"name":9,"description":11,"armGroupLabels":27,"otherNames":25},[9],[29],{"name":30,"affiliation":5,"role":31},"Ludmila Cardozo, PhD","STUDY_DIRECTOR",[33],{"name":34,"role":35,"phone":36,"phoneExt":25,"email":37},"Denise Mafra, PhD","CONTACT","+5521985683003","dmafra30@gmail.com",[39],{"facility":40,"status":41,"city":42,"state":43,"zip":44,"country":45,"cosmosGeoPoint":46,"geoPoint":51,"contacts":52},"Denise Mafra","RECRUITING","Niterói","Rio de Janeiro","24220-900","Brazil",{"type":47,"coordinates":48},"Point",[49,50],-43.10361,-22.88333,{"lat":50,"lon":49},[53],{"name":54,"role":35,"phone":55,"phoneExt":25,"email":56},"Ludmila cardozo","+55987333185","ludmilacardozo@id.uff.br",{"type":58,"investigatorFullName":25,"investigatorTitle":25,"investigatorAffiliation":25,"oldNameTitle":25,"oldOrganization":25},"SPONSOR","100639653",false,"NCT07596966","EFFECTS OF PROPOLIS AND ROYAL JELLY SUPPLEMENTATION ON INFLAMMATORY AND OXIDATIVE STRESS MARKERS IN PATIENTS WITH SYSTEMIC ARTERIAL HYPERTENSION","Inclusion Criteria:\n\n* Diagnosis of stage 1 and 2 hypertension\n* Regular treatment for more than 6 months\n* There have been no changes in medication doses over the last three months.\n\nExclusion Criteria:\n\n* Autoimmune and infectious diseases, diabetes\n* Chronic kidney disease, liver disease, cancer and AIDS\n* Pregnant women\n* Use of catabolic drugs or antibiotics\n* Use of antioxidant vitamin supplements, prebiotics, probiotics, symbiotic\n* Habitual intake of royal jelly and propolis","ALL","18 Years","75 Years",{"count":68,"type":69},48,"ESTIMATED","INTERVENTIONAL",[72],"NA","The study aims to evaluate the effect of the royal jelly and propolis on inflammation and oxidative stress in participants with systemic arterial hypertension. A longitudinal double-blind randomized clinical trial will be carried out, involving hypertensive participants for two months.",[75,76],"Systemic Arterial Hypertension","Inflammation",[78,79,80,81,82],"inflammation","royal jelly","propolis","hypertension","oxidative stress","2026-05-12",{"date":85,"type":86},"2026-05-19","ACTUAL",{"date":88,"type":86},"2025-10-15",{"date":90,"type":69},"2027-12-10",{"name":5,"class":6},1]