[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100469372":3},{"organization":4,"outcomesModule":7,"designInfo":21,"detailedDescription":24,"studyPopulation":25,"armGroups":26,"interventions":32,"overallOfficials":20,"centralContacts":41,"locations":47,"responsibleParty":68,"collaborators":20,"id":70,"slug":20,"hasResults":71,"nctId":72,"briefTitle":73,"officialTitle":73,"acronym":20,"eligibilityCriteria":74,"healthyVolunteers":71,"sex":75,"minAge":76,"maxAge":77,"enrollmentInfo":78,"targetDuration":20,"studyType":81,"phases":20,"briefSummary":82,"conditions":83,"keywords":20,"overallStatus":50,"whyStopped":20,"lastUpdateSubmitDate":85,"lastUpdatePostDateStruct":86,"startDateStruct":89,"completionDateStruct":91,"leadSponsor":93,"locationsCount":94},{"fullName":5,"class":6},"Centre Hospitalier Universitaire Saint Pierre","OTHER",{"primaryOutcomes":8,"secondaryOutcomes":13,"otherOutcomes":20},[9],{"measure":10,"description":11,"timeFrame":12},"the prevalence of obstructive sleep apnea in patients suffering from goiters and planned for partial\u002Ftotal thyroidectomy","percentage","one month",[14,17],{"measure":15,"description":11,"timeFrame":16},"OSA resolution after thyroidectomy in patients suffering from pre-operative OSA","three months after surgery",{"measure":18,"description":19,"timeFrame":16},"body mass index is increased in patients with persisting OSA after surgery","weight and height will be combined to report BMI in kg\u002Fm2",null,{"allocation":20,"interventionModel":20,"interventionModelDescription":20,"primaryPurpose":20,"observationalModel":22,"timePerspective":23,"maskingInfo":20},"COHORT","PROSPECTIVE","Introduction\n\nLiterature regarding effects of goiter on the occurrence of obstructive sleep apnea (OSA) remains scarce. Reports have described cases of OSA in patients suffering from goiters, resolved after thyroidectomy.\n\nIt has been recently shown that goiters of a total volume exceeding 25 mL leads to \\>30% tracheal compression.\n\nThe aims of the present study is to assess 1) the prevalence of OSA in patients suffering from goiters and planned for partial\u002Ftotal thyroidectomy 2) the role of thyroidectomy in OSA resolution in patients suffering from pre-operative OSA 3) the identification of predictors for persisting OSA.\n\nMethods\n\nDesign Prospective study Settings Tertiary referral center, university hospital Patients Patients referred for partial\u002Ftotal thyroidectomy for goiter Baseline assessment All patients planned for thyroidectomy will be prospectively included. Exclusion criteria will be: previous cervical surgery\u002Fradiotherapy, language barrier, chest disease known to narrow upper airways.\n\nPatient will be assessed by home Polysomnography(PSG), one night, Pulmonary function tests, including respiratory muscle strength, and comprehensive biological assessment of thyroid function.\n\nFollow up Three months after thyroidectomy, the same assessment will be repeated.\n\nStatistical analysis\n\nStatistical analysis will be performed to determine the percentage of patients suffering from OSA before surgery (apnea-hypopnea index (AHI) \\>5\u002Fhour of sleep on PSG). As the aim of the present study is to assess the role of thyroidectomy in OSA resolution, we will compare pre- and post-thyroidectomy PSG results in patients exhibiting AHI \\>5\u002Fhour of sleep (chi square test). OSA resolution will be defined as decrease in AHI \\> 50 % or reduction of AHI \\\u003C5hour of sleep. As one of the secondary aim is the identification of predictors for persisting OSA, multivariate analysis will be performed to assess factors of persisting OSA, among age, neck circumference, body mass index, sex, pre\u002Fpost menopausal status and pulmonary function tests parameters.","patients planned for partial\u002Ftotal thyroidectomy for goiter",[27],{"label":28,"type":20,"description":29,"interventionNames":30},"goiter","Patients referred for partial\u002Ftotal thyroidectomy for goiter",[31],"Diagnostic Test: polysomnography",[33],{"type":34,"name":35,"description":36,"armGroupLabels":37,"otherNames":38},"DIAGNOSTIC_TEST","polysomnography","Patient will be assessed by home Polysomnography(PSG), one night, Pulmonary function tests, including respiratory muscle strength, and comprehensive biological assessment of thyroid function.",[28],[39,40],"pulmonary function test","thyroid function tests",[42],{"name":43,"role":44,"phone":45,"phoneExt":20,"email":46},"Marie Bruyneel, MD,PhD","CONTACT","+3225354219","marie.bruyneel@stpierre-bru.be",[48],{"facility":49,"status":50,"city":51,"state":20,"zip":52,"country":53,"countryCode":54,"cosmosGeoPoint":55,"geoPoint":60,"contacts":61},"CHU Saint Pierre","RECRUITING","Brussels","1000","Belgium","BE",{"type":56,"coordinates":57},"Point",[58,59],4.34878,50.85045,{"lat":59,"lon":58},[62,65],{"name":63,"role":44,"phone":64,"phoneExt":20,"email":20},"Marie Bruyneel, MD PhD","003225354219",{"name":66,"role":44,"phone":67,"phoneExt":20,"email":20},"Dimitri Impens, PT","003225353232",{"type":69,"investigatorFullName":20,"investigatorTitle":20,"investigatorAffiliation":20,"oldNameTitle":20,"oldOrganization":20},"SPONSOR","100469372",false,"NCT05391945","Effects of Thyroidectomy on Obstructive Sleep Apnea in Patients Suffering From Goiters","Inclusion Criteria:\n\n°patients planned for thyroidectomy for goiter\n\nExclusion Criteria:\n\n* previous cervical surgery\u002Fradiotherapy\n* language barrier\n* chest disease known to narrow upper airways","ALL","18 Years","90 Years",{"count":79,"type":80},100,"ESTIMATED","OBSERVATIONAL","Literature regarding effects of goiter on the occurrence of obstructive sleep apnea (OSA) remains scarce. Reports have described cases of OSA in patients suffering from goiters, resolved after thyroidectomy.\n\nIt has been recently shown that goiters of a total volume exceeding 25 mL leads to \\>30% tracheal compression.\n\nThe aims of the present study is to assess 1) the prevalence of OSA in patients suffering from goiters and planned for thyroidectomy 2) the role of thyroidectomy in OSA resolution in patients suffering from pre-operative OSA 3) the identification of predictors for persisting OSA.",[84],"Goiter","2024-02-12",{"date":87,"type":88},"2024-02-13","ACTUAL",{"date":90,"type":88},"2022-09-01",{"date":92,"type":80},"2026-12-01",{"name":5,"class":6},1]