[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100543215":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":19,"centralContacts":23,"locations":31,"responsibleParty":47,"collaborators":49,"id":54,"slug":10,"hasResults":55,"nctId":56,"briefTitle":57,"officialTitle":58,"acronym":10,"eligibilityCriteria":59,"healthyVolunteers":55,"sex":60,"minAge":61,"maxAge":10,"enrollmentInfo":62,"targetDuration":10,"studyType":65,"phases":10,"briefSummary":66,"conditions":67,"keywords":71,"overallStatus":34,"whyStopped":10,"lastUpdateSubmitDate":75,"lastUpdatePostDateStruct":76,"startDateStruct":79,"completionDateStruct":81,"leadSponsor":83,"locationsCount":84},{"fullName":5,"class":6},"Lund University","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"Women in labor",null,"Women admitted to labor wards for delivery",[13],"Other: TB infection",[15],{"type":6,"name":16,"description":17,"armGroupLabels":18,"otherNames":10},"TB infection","Outcomes will be compared with regard to result of interferon-gamma release assay test for TB infection",[9],[20],{"name":21,"affiliation":5,"role":22},"Per Bjorkman, MD, PhD","PRINCIPAL_INVESTIGATOR",[24,28],{"name":21,"role":25,"phone":26,"phoneExt":10,"email":27},"CONTACT","+46-40337711","per.bjorkman@med.lu.se",{"name":29,"role":25,"phone":10,"phoneExt":10,"email":30},"Selam Ghebrechristos, MD","selam3148@gmail.com",[32],{"facility":33,"status":34,"city":35,"state":10,"zip":10,"country":36,"cosmosGeoPoint":37,"geoPoint":42,"contacts":43},"Gandhi Memorial Hospital","RECRUITING","Addis Ababa","Ethiopia",{"type":38,"coordinates":39},"Point",[40,41],38.74689,9.02497,{"lat":41,"lon":40},[44],{"name":45,"role":25,"phone":46,"phoneExt":10,"email":30},"Selam Gebrechristos, MD","0921911716438",{"type":48,"investigatorFullName":10,"investigatorTitle":10,"investigatorAffiliation":10,"oldNameTitle":10,"oldOrganization":10},"SPONSOR",[50,52],{"name":51,"class":6},"Addis Ababa University",{"name":53,"class":6},"Armauer Hansen Research Institute, Ethiopia","100543215",false,"NCT06352970","Effects of Tuberculosis Infection on Development and Function of the Placenta","Effects of Tuberculosis Infection on Placental Development and Function","Inclusion Criteria:\n\n* Women admitted for delivery to study sites\n* Written informed consent\n* Age 18 years or greater\n\nExclusion Criteria:\n\n* Chronic comorbidities (other than TB, HIV or pregnancy-related disorder)\n* Twin pregnancy","FEMALE","18 Years",{"count":63,"type":64},500,"ESTIMATED","OBSERVATIONAL","The goal of this observational study is to understand how tuberculosis (TB) infection impacts the function and development of the placenta, and whether TB infection can contribute to pregnancy-related disorders through effects on the placenta.\n\nThe main questions it aims to answer are:\n\n* Does TB infection affect the structure of the placenta?\n* Does TB infection affect the function of the placenta?\n\nPregnant women attending delivery clinics in Addis Abeba, Ethiopia, will be enrolled and classified for TB infection using a blood-based test. We will compare the following outcomes between women with TB infection and women without TB infection:\n\n* Pathological lesions of the placenta\n* Gene and protein expression patterns linked to pregnancy-related disorders\n* Infant outcome at birth and at 6 weeks after birth",[68,69,70],"Pregnancy Related","Tuberculosis Infection","Placenta Diseases",[72,73,74],"placenta","tuberculosis","pregnancy complication","2025-03-14",{"date":77,"type":78},"2025-03-17","ACTUAL",{"date":80,"type":78},"2024-10-01",{"date":82,"type":64},"2027-12-31",{"name":5,"class":6},1]