Efficacy and Safety of Intra-articular Injections of Frozen Platelet-Rich Plasma in Patients With Knee Osteoarthritis

Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age40-85
SponsorMiKS Hospital

About this trial

Evaluation of intra-articular injections in knee osteoarthritis using frozen-stored PRP. Compared with intra-articular injections of PRP applied at the time of collection.

Eligibility criteria

This trial does not accept healthy volunteers

Qualifiers

Patients of both sexes.

Aged between 40 and 85 years old.

Diagnosed with osteoarthritis through clinical radiological examination.

Joint pain equal to or less than 75 points on the KOOS (pain).

Disqualifiers

Body mass index >35

Diagnosed polyarticular disease.

Previous arthroscopy in the last year.

Severe mechanical deformity.

Trial design

Design model

Parallel

Treatments tested in this trial

  • Platelet Rich Plasma

    Other intervention

    Platelet-rich plasma stored by freezing

  • Platelet Rich Plasma

    Other intervention

    Fresh Platelet-Rich Plasma

Treatment groups

60 Participants
are divided into 2 treatment groups
Group A: Frozen Platelet-Rich PlasmaExperimental treatment 1 intervention
Group B: Platelet-Rich PlasmaActive comparator 1 intervention

Trial outcomes

Primary outcomes

1

KOOS - Knee Injury and Osteoarthritis Outcome Score

From 0 (worst outcome) to 100 (best outcome)

Time frame
6 months

Secondary outcomes

1

KOOS - Knee Injury and Osteoarthritis Outcome Score

From 0 (worst outcome) to 100 (best outcome)

Time frame
2 months
2

VAS - Visual Analog Scale

From 0 (best outcome) to 10 (worst outcome)

Time frame
2 months
3

VAS - Visual Analog Scale

From 0 (best outcome) to 10 (worst outcome)

Time frame
6 months
4

Lequesne Index

A patient-completed questionnaire used to measure the severity of osteoarthritis assessing pain and function. From 0 (best outcome) to 24 (worst outcome)

Time frame
2 months

Other outcomes

Sponsors and contacts

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