[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100555672":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":31,"centralContacts":36,"locations":45,"responsibleParty":88,"collaborators":91,"id":96,"slug":26,"hasResults":97,"nctId":98,"briefTitle":99,"officialTitle":100,"acronym":101,"eligibilityCriteria":102,"healthyVolunteers":97,"sex":103,"minAge":104,"maxAge":105,"enrollmentInfo":106,"targetDuration":26,"studyType":109,"phases":110,"briefSummary":112,"conditions":113,"keywords":116,"overallStatus":48,"whyStopped":26,"lastUpdateSubmitDate":118,"lastUpdatePostDateStruct":119,"startDateStruct":122,"completionDateStruct":124,"leadSponsor":126,"locationsCount":127},{"fullName":5,"class":6},"Huashan Hospital","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"SCS group","EXPERIMENTAL","SCS stimulation therapy is initiated 1 week post-surgery, which is administered continuously for a duration of 6 months.",[13],"Procedure: SCS Stimulation",{"label":15,"type":16,"description":17,"interventionNames":18},"Sham group","SHAM_COMPARATOR","Sham stimulation therapy is initiated 1 week post-surgery, and SCS stimulation therapy is initiated 3 months post-surgery, which is stimulated continuously for a duration of 3 months.",[19],"Procedure: Sham Stimulation",[21,27],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"PROCEDURE","SCS Stimulation","Participants will accept the SCS stimulus for six months",[9],null,{"type":22,"name":28,"description":29,"armGroupLabels":30,"otherNames":26},"Sham Stimulation","Sham stimulation will be performed in the first three months after surgery, and SCS stimulation will be started in the fourth month after surgery",[15],[32],{"name":33,"affiliation":34,"role":35},"Xuehai Wu, Ph.D.","Department of Neurosurgery, Huashan Hospital, Fudan University","PRINCIPAL_INVESTIGATOR",[37,41],{"name":33,"role":38,"phone":39,"phoneExt":26,"email":40},"CONTACT","+8613764880571","Wuxuehai2013@163.com",{"name":42,"role":38,"phone":43,"phoneExt":26,"email":44},"Lijian Lang, M.M.","+8613896851367","lang_lijian@163.com",[46,63,77],{"facility":47,"status":48,"city":49,"state":50,"zip":51,"country":52,"cosmosGeoPoint":53,"geoPoint":58,"contacts":59},"The First Affiliated Hospital of Fujian Medical University","RECRUITING","Fuzhou","Fujian","350000","China",{"type":54,"coordinates":55},"Point",[56,57],119.30611,26.06139,{"lat":57,"lon":56},[60],{"name":61,"role":38,"phone":62,"phoneExt":26,"email":26},"Peisen Yao, Ph.D.","18650084102",{"facility":64,"status":48,"city":65,"state":66,"zip":67,"country":52,"cosmosGeoPoint":68,"geoPoint":72,"contacts":73},"Xiangya Hospital,Central South University","Changsha","Hunan","410000",{"type":54,"coordinates":69},[70,71],112.97087,28.19874,{"lat":71,"lon":70},[74],{"name":75,"role":38,"phone":76,"phoneExt":26,"email":26},"Zhongyi Sun, Ph.D.","18163618671",{"facility":34,"status":48,"city":78,"state":79,"zip":80,"country":52,"cosmosGeoPoint":81,"geoPoint":85,"contacts":86},"Shanghai","Shanghai Municipality","200000",{"type":54,"coordinates":82},[83,84],121.45806,31.22222,{"lat":84,"lon":83},[87],{"name":33,"role":38,"phone":39,"phoneExt":26,"email":40},{"type":35,"investigatorFullName":89,"investigatorTitle":90,"investigatorAffiliation":5,"oldNameTitle":26,"oldOrganization":26},"Xuehai Wu","Deputy Director of Shanghai Neurosurgical Emergency Center",[92,94],{"name":93,"class":6},"Xiangya Hospital of Central South University",{"name":95,"class":6},"First Affiliated Hospital of Fujian Medical University","100555672",false,"NCT06515132","Efficacy and Safety of Spinal Cord Stimulation in Patients With Spinal Cord Stimulation","Efficacy and Safety of Spinal Cord Stimulation in Patients With Disorders of Consciousness: A Multicenter, Double-blind, Randomized Controlled Trail","SCORS-DOC","Inclusion Criteria:\n\n* Male and female patients between the ages of 18 and 65, experiencing DOC for a duration ranging from 3 months to 1 year following brain disease.\n* Patients diagnosed with DOC as a consequence of traumatic brain injury, hypertensive intracerebral hemorrhage, or severe cerebral infarction.\n* Patients exhibiting stable cerebral anatomy and no need for further cranioplasty or hydrocephalus shunt.\n* Patients in MCS, who fulfill at least one of the following criteria: ① Demonstrating an oriented response to noxious stimuli; ② Exhibiting sustained eye tracking behavior; ③ Displaying purposeful movements; ④ Manifesting comprehension of language or emotions and actions (often observed in specific environments such as when hearing family members crying).\n* The vital signs and state of consciousness are stable: normal body temperature, the spontaneous breathing is stable (minimal sputum production and respiratory stability without oxygen supplementation for at least 2 hours); there is no significant change in the level of consciousness for at least 1 month and more.\n* Presence of short-latency responses (N20\u002FP25) on somatosensory evoked potentials (SEP) recorded from the median nerve in the upper limbs.\n* Written informed consent obtained from legal guardians or representatives.\n\nExclusion Criteria:\n\n* Patients with a history of severe neurological or psychiatric disorders, or other significant diseases impacting prognosis prior to the onset of DOC;\n* Patients with contraindications for surgery, such as acute infections or coagulation disorders;\n* Patients who require short-wave diathermy treatment and are unable to undergo neurostimulation;\n* Patients with hypoxic brain injury due to suffocation, cardiac arrest, or respiratory arrest;\n* Patients with brainstem hemorrhage;\n* Pregnant women;\n* Patients who voluntarily request SCS implantation but are unwilling to cooperate with the research protocol;\n* Participants in other clinical trials.","ALL","18 Years","65 Years",{"count":107,"type":108},50,"ESTIMATED","INTERVENTIONAL",[111],"NA","Investigating the efficacy and safety of spinal cord stimulation for patients with disorders of consciousness.",[114,115],"Disorder of Consciousness","Spinal Cord Stimulation",[114,115,117],"Randomized clinical trail","2025-01-04",{"date":120,"type":121},"2025-01-07","ACTUAL",{"date":123,"type":108},"2025-01-10",{"date":125,"type":108},"2026-05-30",{"name":5,"class":6},3]