This study will analyze the clinical indicators, imaging data, and serum biomarkers of Alzheimer's disease (AD) patients receiving different doses of the medication before and after treatment. It aims to clarify whether the therapeutic efficacy in the low-dose group is equivalent to that in the recommended-dose group, and meanwhile to determine the optimal dose range for effective pharmacotherapy.
Meet the diagnostic criteria for AD-derived MCI or early AD [Clinical rating: CDR 0.5 (MCI) / 1.0 (mild AD), i.e., clinical stage 3-5; PIB-PET positive for pathology]
Male or female
50-85 years old
Not currently participating in other research studies
Other neurological disorders: e.g., vascular dementia, dementia with Lewy bodies, frontotemporal lobar degeneration, prion diseases, etc.
Systemic diseases or metabolic disorders: e.g., hypothyroidism, vitamin B12 deficiency, hepatic and renal failure.
Infectious diseases: e.g., neurosyphilis, HIV-associated encephalopathy, and other infectious diseases.
Psychiatric disorders: cognitive symptoms caused by severe depression (pseudodementia), schizophrenia, etc.
Second Affiliated Hospital, School of Medicine, Zhejiang University
Lead sponsor