[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100622332":3},{"organization":4,"outcomesModule":7,"designInfo":24,"detailedDescription":30,"studyPopulation":23,"armGroups":31,"interventions":44,"overallOfficials":23,"centralContacts":54,"locations":60,"responsibleParty":81,"collaborators":23,"id":84,"slug":23,"hasResults":85,"nctId":86,"briefTitle":87,"officialTitle":88,"acronym":23,"eligibilityCriteria":89,"healthyVolunteers":85,"sex":90,"minAge":91,"maxAge":92,"enrollmentInfo":93,"targetDuration":23,"studyType":96,"phases":97,"briefSummary":99,"conditions":100,"keywords":103,"overallStatus":107,"whyStopped":23,"lastUpdateSubmitDate":108,"lastUpdatePostDateStruct":109,"startDateStruct":112,"completionDateStruct":114,"leadSponsor":116,"locationsCount":117},{"fullName":5,"class":6},"October University for Modern Sciences and Arts","OTHER",{"primaryOutcomes":8,"secondaryOutcomes":13,"otherOutcomes":23},[9],{"measure":10,"description":11,"timeFrame":12},"Caries arrest of active dentin caries","Arrest of caries assessed clinically by hardness of dentin using blunt periodontal probe and ICDAS criteria","1, 3, 6, 9 and 12 months",[14,17,20],{"measure":15,"description":16,"timeFrame":12},"Discoloration of carious lesions","Assessment of color change using standardized pre- and post-operative photographs",{"measure":18,"description":19,"timeFrame":12},"Post-operative pain","Presence or absence of pain assessed through parental interview",{"measure":21,"description":22,"timeFrame":12},"Parental satisfaction","Evaluation using a structured parental satisfaction questionnaire",null,{"allocation":25,"interventionModel":26,"interventionModelDescription":23,"primaryPurpose":27,"observationalModel":23,"timePerspective":23,"maskingInfo":28},"RANDOMIZED","PARALLEL","TREATMENT",{"masking":29,"maskingDescription":23,"whoMasked":23},"NONE","This randomized clinical trial will be conducted on 30 children aged 3-5 years attending the outpatient clinic of Pediatric Dentistry, Faculty of Dentistry, Suez Canal University. Children with active dentin caries in primary molars will be randomly allocated into two groups: Silver Diamine Fluoride group and Nano-Silver Fluoride group.\n\nBoth materials will be applied topically without caries excavation. Clinical evaluation will be performed at baseline and at 1, 3, 6, 9, and 12 months using ICDAS criteria, visual and tactile examination, assessment of post-operative pain, discoloration through standardized photographs, and parental satisfaction questionnaires.\n\nThe primary outcome is caries arrest. Secondary outcomes include discoloration, pain, and parental satisfaction.",[32,38],{"label":33,"type":34,"description":35,"interventionNames":36},"Arm A: Nano-Silver Fluoride","EXPERIMENTAL","Topical application of Nano-Silver Fluoride varnish containing silver nanoparticles, chitosan, and fluoride applied to active dentin caries lesions in primary molars. Application will be performed twice: at baseline and after 6 months, without caries excavation or restoration.",[37],"Drug: Nano-Silver Fluoride",{"label":39,"type":40,"description":41,"interventionNames":42},"Arm B: Silver Diamine Fluoride","ACTIVE_COMPARATOR","Topical application of 38% Silver Diamine Fluoride varnish applied to active dentin caries lesions in primary molars. Application will be performed twice: at baseline and after 6 months, without caries excavation or restoration.",[43],"Drug: Silver Diamine Fluoride",[45,50],{"type":46,"name":47,"description":48,"armGroupLabels":49,"otherNames":23},"DRUG","Nano-Silver Fluoride","Chitosan (28,585 μg\u002Fml), Silver (376.5 μg\u002Fml) and Sodium fluoride (5028.3 μg\u002Fml)",[33],{"type":46,"name":51,"description":52,"armGroupLabels":53,"otherNames":23},"Silver Diamine Fluoride","38% Silver Diamine Fluoride",[39],[55],{"name":56,"role":57,"phone":58,"phoneExt":23,"email":59},"Khaled Abdelmonem Sayed Assistant Lecturer at Pediatric Dentistry Department, Master Holder","CONTACT","+201114537612","kasayed@msa.edu.eg",[61],{"facility":62,"status":23,"city":63,"state":64,"zip":65,"country":66,"countryCode":67,"cosmosGeoPoint":68,"geoPoint":73,"contacts":74},"Faculty of Dentistry, MSA University","Giza","Giza Governorate","12611","Egypt","EG",{"type":69,"coordinates":70},"Point",[71,72],31.20861,30.00944,{"lat":72,"lon":71},[75,78],{"name":76,"role":57,"phone":77,"phoneExt":23,"email":59},"Khaled Abdelmonem, Master degree","01114537612",{"name":79,"role":80,"phone":23,"phoneExt":23,"email":23},"khaled Abdelmonem, master degree","PRINCIPAL_INVESTIGATOR",{"type":80,"investigatorFullName":82,"investigatorTitle":83,"investigatorAffiliation":5,"oldNameTitle":23,"oldOrganization":23},"khaled sayed","lecturer assistant at pediatric dentistry department- faculty of dentistry- October University for Modern Sciences and Arts -","100622332",false,"NCT07382245","Efficacy of Silver Diamine Fluoride Versus Nano-Silver Fluoride in Arresting Active Dentin Caries in Primary Teeth in Young Children","Efficacy of Silver Diamine Fluoride Versus Nano-Silver Fluoride in Arresting Active Dentin Caries in Primary Teeth in Young Children: A Randomized Clinical Trial","Inclusion Criteria:\n\n* Apparently healthy children.\n* Children with age ranged from 3-5 years from both genders.\n* Children who refused dental treatment with Frankl Behavior Rating Scale 1 and 2.\n* Children having molars with active dentin caries score (2,3,4) according to International Caries Detection and Assessment System- ICDAS II, detected by visual and tactile.\n* Parents\u002Fguardians accept treatment and write informed consent.\n\nExclusion Criteria:\n\n* Children with allergy to silver from their medical history.\n* Children with ulcerative gingivitis.\n* Children with primary molars with the following criteria:\n* Symptomatic\n* Involving the pulp\n* Presence of fistula or sinus\n* Presence of gingival inflammation and Pain on percussion\n* Close to exfoliation","ALL","3 Years","5 Years",{"count":94,"type":95},60,"ESTIMATED","INTERVENTIONAL",[98],"NA","Early childhood caries is a major public health problem affecting preschool children worldwide. Silver Diamine Fluoride is a well-established non-invasive treatment for arresting caries; however, it causes black discoloration of treated lesions. Nano-Silver Fluoride has been introduced as an alternative that may arrest caries without discoloration.\n\nThis randomized clinical trial aims to compare the efficacy of Silver Diamine Fluoride and Nano-Silver Fluoride in arresting active dentin caries in primary teeth and to assess discoloration, post-operative pain, and parental satisfaction over a 12-month follow-up period.",[101,102],"Early Childhood Caries (ECC)","Active Dentin Caries in Primary Molars",[104,105,47,51,106],"Early Childhood Caries","primary molar","SDF","NOT_YET_RECRUITING","2026-01-25",{"date":110,"type":111},"2026-02-02","ACTUAL",{"date":113,"type":95},"2026-01-30",{"date":115,"type":95},"2026-03-15",{"name":5,"class":6},1]