[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100638514":3},{"organization":4,"armGroups":7,"interventions":15,"overallOfficials":29,"centralContacts":30,"locations":36,"responsibleParty":54,"collaborators":29,"id":58,"slug":29,"hasResults":59,"nctId":60,"briefTitle":61,"officialTitle":62,"acronym":29,"eligibilityCriteria":63,"healthyVolunteers":59,"sex":64,"minAge":65,"maxAge":29,"enrollmentInfo":66,"targetDuration":29,"studyType":69,"phases":70,"briefSummary":72,"conditions":73,"keywords":78,"overallStatus":83,"whyStopped":29,"lastUpdateSubmitDate":84,"lastUpdatePostDateStruct":85,"startDateStruct":88,"completionDateStruct":90,"leadSponsor":92,"locationsCount":93},{"fullName":5,"class":6},"First Affiliated Hospital of Wannan Medical College","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"Experimental Arm: Sequential Vasodilator Infusion","EXPERIMENTAL","All participants will receive sequential intravenous infusions of nicardipine and nitroglycerin under controlled ICU monitoring.\n\nDrug Intervention 1: nitroglycerin\n\nDosage: 5-100 µg\u002Fmin continuous IV infusion. Duration: 30 minutes. EIT and arterial blood gas measurements will be taken before and after infusion.\n\nDrug Intervention 2: Nicardipine\n\nDosage: 1-5 mg\u002Fh continuous IV infusion. Duration: 30 minutes. EIT and arterial blood gas measurements will be taken before and after infusion.\n\nTechnique:\n\nElectrical Impedance Tomography (PulmoVista 500 or equivalent) used to obtain ventilation and perfusion maps and calculate V\u002FQ matching indices.\n\nNo placebo or parallel control arm - each subject serves as their own control in a crossover design.",[13,14],"Drug: Nitroglycerin","Drug: Nicardipine",[16,23],{"type":17,"name":18,"description":19,"armGroupLabels":20,"otherNames":21},"DRUG","Nitroglycerin","Continuous intravenous infusion of nitroglycerin for blood pressure reduction in acute respiratory failure. The drug is administered at an initial rate of 5 µg\u002Fmin, titrated up to 100 µg\u002Fmin as needed to maintain target mean arterial pressure (MAP 65-85 mmHg). Each infusion period lasts 30 minutes under stable mechanical ventilation. Hemodynamic parameters, arterial blood gases, and electrical impedance tomography (EIT) data are recorded at Baseline, 30 min, and 60 min. A washout phase is observed before crossover to the second intervention.",[9],[22],"Glyceryl Trinitrate; Nitroglycerin Injection; Tridil®",{"type":17,"name":24,"description":25,"armGroupLabels":26,"otherNames":27},"Nicardipine","Continuous intravenous infusion of nicardipine for blood pressure control during mechanical ventilation. The infusion begins at 1 mg\u002Fh and is titrated up to 5 mg\u002Fh according to real-time blood pressure monitoring to maintain target MAP 65-85 mmHg. Each infusion period lasts 30 minutes. Electrical impedance tomography (EIT) is used to record ventilation-perfusion matching, dead-space, and shunt fraction at Baseline, 30 min, and 60 min. After completion, a 30-minute washout period or until baseline hemodynamics are restored precedes the next crossover phase.",[9],[28],"Cardene; Nicardipine Hydrochloride",null,[31],{"name":32,"role":33,"phone":34,"phoneExt":29,"email":35},"qiancheng xu, PhD","CONTACT","+86-18297529106","qianchengxu@wnmc.edu.cn",[37],{"facility":38,"status":29,"city":39,"state":40,"zip":41,"country":42,"cosmosGeoPoint":43,"geoPoint":48,"contacts":49},"The First Affiliated Hospital of Wannan Medical College (Yijishan Hospital of Wannan Medical College)","Wuhu","Anhui","241001","China",{"type":44,"coordinates":45},"Point",[46,47],118.42947,31.35259,{"lat":47,"lon":46},[50],{"name":51,"role":33,"phone":52,"phoneExt":29,"email":53},"Shengsheng Tao","86-18315329399","taoshengsheng@yjsyy.com",{"type":55,"investigatorFullName":56,"investigatorTitle":57,"investigatorAffiliation":5,"oldNameTitle":29,"oldOrganization":29},"PRINCIPAL_INVESTIGATOR","Qiancheng Xu","Principal Investigator","100638514",false,"NCT07603037","EIT Evaluation of Different Antihypertensive Agents on the Ventilation-Perfusion Ratio in Patients With Acute Respiratory Failure","Effect of Nicardipine and Nitroglycerin on the Ventilation-Perfusion Ratio in Patients With Acute Respiratory Failure Using Electrical Impedance Tomography: A Prospective Pilot Study","Inclusion Criteria Diagnosis of acute respiratory failure with PaO₂\u002FFiO₂ ≤ 300 mmHg, requiring invasive mechanical ventilation.\n\nRequires intravenous antihypertensive infusion (such as nicardipine or nitroglycerin) to maintain controlled and stable blood pressure during ICU treatment.\n\nWritten informed consent obtained from the patient or the legally authorized representative.\n\nExclusion Criteria:\n\nBody mass index (BMI) ≥ 50 kg\u002Fm² or presence of massive subcutaneous edema interfering with EIT signal acquisition.\n\nImplanted cardiac pacemaker, defibrillator, or any metallic thoracic device that may distort impedance measurements.\n\nHemodynamic instability or severe hypotension occurring during drug titration. Pregnancy or lactation. Known hypersensitivity or contraindication to nicardipine or nitroglycerin. Use of phosphodiesterase-5 inhibitors, such as sildenafil, tadalafil, or vardenafil, within the clinically relevant washout period.\n\nSevere anemia, markedly increased intracranial pressure, or other clinical conditions in which nitroglycerin administration is considered inappropriate by the treating physician.\n\nIncomplete clinical documentation preventing accurate evaluation of primary endpoints.","ALL","18 Years",{"count":67,"type":68},12,"ESTIMATED","INTERVENTIONAL",[71],"NA","This prospective, single-center interventional study aims to evaluate the effect of two commonly used intravenous antihypertensive agents - nicardipine and nitroglycerin - on lung ventilation-perfusion (V\u002FQ) distribution in patients with acute respiratory failure complicated by hypertension. Electrical Impedance Tomography (EIT) will be used for noninvasive monitoring of pulmonary ventilation and perfusion distribution before and after drug administration.\n\nThe study will compare the changes in V\u002FQ ratio, oxygenation index, and hemodynamic variables after administration of the two drugs. The findings are expected to provide evidence for the optimal antihypertensive strategy in critically ill patients with respiratory failure and to clarify whether specific vasodilators exacerbate or improve ventilation-perfusion mismatch.",[74,75,76,77],"Acute Respiratory Failure (ARF)","Hypertension","Pulmonary Perfusion Imbalance","Aortic Dissection (Subset)",[79,80,24,81,82,18],"Electrical Impedance Tomography","Ventilation-Perfusion Ratio","Acute Respiratory Failure","Intensive Care Unit","NOT_YET_RECRUITING","2026-06-30",{"date":86,"type":87},"2026-07-02","ACTUAL",{"date":89,"type":68},"2026-07-15",{"date":91,"type":68},"2027-07-30",{"name":5,"class":6},1]