[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100645231":3},{"organization":4,"armGroups":7,"interventions":10,"overallOfficials":15,"centralContacts":20,"locations":25,"responsibleParty":90,"collaborators":93,"id":102,"slug":10,"hasResults":103,"nctId":104,"briefTitle":105,"officialTitle":106,"acronym":107,"eligibilityCriteria":108,"healthyVolunteers":103,"sex":109,"minAge":110,"maxAge":10,"enrollmentInfo":111,"targetDuration":10,"studyType":114,"phases":10,"briefSummary":115,"conditions":116,"keywords":120,"overallStatus":28,"whyStopped":10,"lastUpdateSubmitDate":126,"lastUpdatePostDateStruct":127,"startDateStruct":130,"completionDateStruct":132,"leadSponsor":134,"locationsCount":135},{"fullName":5,"class":6},"University of Bari","OTHER",[8,12],{"label":9,"type":10,"description":11,"interventionNames":10},"Fibromyalgia cases",null,"Adults with fibromyalgia diagnosed per the 2016 ACR criteria.",{"label":13,"type":10,"description":14,"interventionNames":10},"Non-fibromyalgia chronic pain controls","Adults with chronic non-cancer pain of defined nociceptive or neuropathic origin who do not meet the 2016 ACR criteria for fibromyalgia.",[16],{"name":17,"affiliation":18,"role":19},"Alberto Corriero, MD, PhD","University of Bari Aldo Moro, Pain and ICU Section","PRINCIPAL_INVESTIGATOR",[21],{"name":17,"role":22,"phone":23,"phoneExt":10,"email":24},"CONTACT","+39 3280072443","alberto.corriero@gmail.com",[26,44,57,68,79],{"facility":27,"status":28,"city":29,"state":10,"zip":30,"country":31,"cosmosGeoPoint":32,"geoPoint":37,"contacts":38},"Pain Unit, Policlinico di Bari, University of Bari Aldo Moro (coordinating center)","RECRUITING","Bari","70124","Italy",{"type":33,"coordinates":34},"Point",[35,36],16.86982,41.12066,{"lat":36,"lon":35},[39,41,42],{"name":40,"role":19,"phone":10,"phoneExt":10,"email":10},"Filomena Puntillo, MD",{"name":17,"role":19,"phone":10,"phoneExt":10,"email":10},{"name":43,"role":19,"phone":10,"phoneExt":10,"email":10},"Mariateresa Giglio, MD",{"facility":45,"status":46,"city":47,"state":10,"zip":48,"country":31,"cosmosGeoPoint":49,"geoPoint":53,"contacts":54},"Anesthesia and Pain Therapy Unit, IRCCS AOSP di Bologna, Policlinico S. Orsola-Malpighi","NOT_YET_RECRUITING","Bologna","40138",{"type":33,"coordinates":50},[51,52],11.33875,44.49381,{"lat":52,"lon":51},[55],{"name":56,"role":19,"phone":10,"phoneExt":10,"email":10},"Samolsky Dekel Boaz, MD",{"facility":58,"status":46,"city":59,"state":10,"zip":10,"country":31,"cosmosGeoPoint":60,"geoPoint":64,"contacts":65},"Department of Medical Sciences and Public Health, University of Cagliari","Cagliari",{"type":33,"coordinates":61},[62,63],9.11917,39.23054,{"lat":63,"lon":62},[66],{"name":67,"role":19,"phone":10,"phoneExt":10,"email":10},"Gabriele Finco, MD",{"facility":69,"status":46,"city":70,"state":10,"zip":10,"country":31,"cosmosGeoPoint":71,"geoPoint":75,"contacts":76},"Department of Women, Child and General and Specialized Surgery, University of Campania Luigi Vanvitelli","Naples",{"type":33,"coordinates":72},[73,74],14.26811,40.85216,{"lat":74,"lon":73},[77],{"name":78,"role":19,"phone":10,"phoneExt":10,"email":10},"Maria Caterina Pace, MD",{"facility":80,"status":46,"city":81,"state":10,"zip":10,"country":31,"cosmosGeoPoint":82,"geoPoint":86,"contacts":87},"Department of Surgery, Dentistry, Pediatrics and Gynecology, University of Verona","Verona",{"type":33,"coordinates":83},[84,85],10.9938,45.43854,{"lat":85,"lon":84},[88],{"name":89,"role":19,"phone":10,"phoneExt":10,"email":10},"Vittorio Schweiger, MD, PhD",{"type":19,"investigatorFullName":17,"investigatorTitle":91,"investigatorAffiliation":92,"oldNameTitle":10,"oldOrganization":10},"Principal Investigator","University of Bari Aldo Moro",[94,96,98,100],{"name":95,"class":6},"Universita di Verona",{"name":97,"class":6},"University of Campania Luigi Vanvitelli",{"name":99,"class":6},"University of Cagliari",{"name":101,"class":6},"IRCCS Azienda Ospedaliero-Universitaria di Bologna","100645231",false,"NCT07677631","Emotional Allodynia Questionnaire (AEQ) in Fibromyalgia (PEARL)","Pain, Emotional Allodynia, and Relational Load (PEARL): A Multicenter Validation Study of the Emotional Allodynia Questionnaire in Fibromyalgia","PEARL","CASES (fibromyalgia)\n\nInclusion Criteria:\n\n* Age 18 years or older\n* Clinical diagnosis of fibromyalgia confirmed according to the 2016 revision of the ACR criteria\n* Chronic non-cancer pain for at least 3 months\n* Ability to understand and independently complete self-report questionnaires in Italian\n* Willingness to provide written informed consent\n\nExclusion Criteria:\n\n* Active oncological disease or cancer-related pain\n* Any current or past psychiatric diagnosis except Major Depressive Disorder and Panic Disorder (assessed by clinical history)\n* Severe cognitive impairment precluding questionnaire completion\n* Inability to understand or complete questionnaires in Italian\n\nCONTROLS (non-fibromyalgia chronic pain)\n\nInclusion Criteria:\n\n* Age 18 years or older\n* Chronic non-cancer pain for at least 3 months with a defined nociceptive or neuropathic generator (e.g., radiologically or surgically documented degenerative, structural, or post-surgical musculoskeletal pain, or neuropathic pain with an identifiable neurological lesion or disease)\n* Not meeting the 2016 ACR criteria for fibromyalgia\n* Ability to understand and independently complete self-report questionnaires in Italian\n* Willingness to provide written informed consent\n\nExclusion Criteria (parallel to cases):\n\n* Diagnosis of fibromyalgia or another recognized nociplastic primary pain condition (e.g., primary chronic widespread pain)\n* Active oncological disease or cancer-related pain\n* Any current or past psychiatric diagnosis except Major Depressive Disorder and Panic Disorder\n* Severe cognitive impairment precluding questionnaire completion\n* Inability to understand or complete questionnaires in Italian\n\nNote: ongoing pharmacological treatment for pain or mental health is not an exclusion criterion in either group; Major Depressive Disorder and Panic Disorder are recorded at baseline and used in covariate-adjusted and stratified analyses.","ALL","18 Years",{"count":112,"type":113},423,"ESTIMATED","OBSERVATIONAL","The Emotional Allodynia Questionnaire (AEQ) is an 11-item self-report instrument that measures disproportionate emotional reactivity to low-intensity interpersonal cues(perceived unresponsiveness, exclusion, loss of reciprocity), a pattern termed emotional allodynia. It was preliminarily validated in a single-center fibromyalgia sample. PEARL (validation phase) is a multicenter, prospective, observational psychometric validation study that (1) replicates the internal structure and convergent validity of the AEQ in an independent fibromyalgia sample, (2) tests its known-groups (discriminative) accuracy in separating fibromyalgia from non-fibromyalgia chronic pain of defined nociceptive or neuropathic origin, expressed as the area under the ROC curve (AUC), and (3) assesses test-retest reliability. There is no intervention.",[117,118,119],"Fibromyalgia","Chronic Pain","Nociplastic Pain",[121,117,122,123,124,125],"Emotional Allodynia Questionnaire","Nociplastic pain","Psychometric validation","Central sensitization","Emotion regulation","2026-06-24",{"date":128,"type":129},"2026-07-01","ACTUAL",{"date":131,"type":129},"2025-09-10",{"date":133,"type":113},"2027-08",{"name":5,"class":6},5]