[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100600469":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":25,"centralContacts":30,"locations":36,"responsibleParty":48,"collaborators":52,"id":56,"slug":25,"hasResults":57,"nctId":58,"briefTitle":59,"officialTitle":60,"acronym":25,"eligibilityCriteria":61,"healthyVolunteers":57,"sex":62,"minAge":63,"maxAge":25,"enrollmentInfo":64,"targetDuration":25,"studyType":67,"phases":68,"briefSummary":70,"conditions":71,"keywords":73,"overallStatus":76,"whyStopped":25,"lastUpdateSubmitDate":77,"lastUpdatePostDateStruct":78,"startDateStruct":81,"completionDateStruct":83,"leadSponsor":85,"locationsCount":86},{"fullName":5,"class":6},"China-Japan Friendship Hospital","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"ESV and Optimal Medical Management","EXPERIMENTAL","This study arm will undergo ESV treatment along with optimal medical management, including smoking cessation program, pulmonary rehabilitation, usual medications and oxygen supplementation as necessary.",[13],"Device: ESV",{"label":15,"type":6,"description":16,"interventionNames":17},"EBV and Optimal Medical Management","This study arm will undergo EBV treatment along with optimal medical management, including smoking cessation program, pulmonary rehabilitation, usual medications and oxygen supplementation as necessary.",[18],"Device: EBV",[20,26],{"type":21,"name":22,"description":23,"armGroupLabels":24,"otherNames":25},"DEVICE","ESV","This study arm will undergo ESV treatment and also receive optimal medical management, including smoking cessation program support, pulmonary rehabilitation, usual medications and oxygen supplementation as necessary.",[9],null,{"type":21,"name":27,"description":28,"armGroupLabels":29,"otherNames":25},"EBV","This study arm will undergo EBV treatment and also receive optimal medical management, including smoking cessation program support, pulmonary rehabilitation, usual medications and oxygen supplementation as necessary.",[15],[31],{"name":32,"role":33,"phone":34,"phoneExt":25,"email":35},"Mingming Deng, PhD., MD.","CONTACT","+86 18801336854","isdeng1017@163.com",[37],{"facility":5,"status":25,"city":38,"state":39,"zip":40,"country":41,"cosmosGeoPoint":42,"geoPoint":47,"contacts":25},"Beijing","Beijing Municipality","100029","China",{"type":43,"coordinates":44},"Point",[45,46],116.39723,39.9075,{"lat":46,"lon":45},{"type":49,"investigatorFullName":50,"investigatorTitle":51,"investigatorAffiliation":5,"oldNameTitle":25,"oldOrganization":25},"PRINCIPAL_INVESTIGATOR","Gang Hou","Principal Investigator",[53],{"name":54,"class":55},"Beijing Cardiotech Medical Technology CO., LTD","UNKNOWN","100600469",false,"NCT07097896","Endobronchial Silicone Valve for Patients With Emphysema","Bronchoscopic Lung Volume Reduction With Endobronchial Silicone Valve for Patients With Emphysema: a Randomised Controlled Trial","Inclusion Criteria:\n\n* Clinical and radiological evidence of emphysema\n* Nonsmoking for 4 months prior to screening interview\n* BMI less than 35 kg\u002Fm2\n* Stable on current medication regimen\n* Forced expiratory volume in one second (FEV1) between 15% and 45% of predicted value\n* Residual Volume less than 175% predicted (determined by body plethysmography)\n* Little or no collateral ventilation (CV-) as determined using the Chartis System\n\nExclusion Criteria:\n\n* Had two or more hospitalizations over the last year for a COPD exacerbation\n* Had two or more hospitalizations over the last year for pneumonia\n* Had a prior lung transplant, lung volume reduction surgery, bullectomy or lobectomy\n* Had a heart attack or congestive heart failure within the last 6 months\n* Have heart arrhythmia\n* Is alpha-1 antitrypsin deficient","ALL","18 Years",{"count":65,"type":66},147,"ESTIMATED","INTERVENTIONAL",[69],"NA","The purpose of this research is to compare the efficacy and safety between endobronchial silicone valve and endobronchial valve in bronchoscopic lung volume reduction in patients with severe emphysema.",[72],"Emphysema",[74,72,75],"Endobronchial Lung Volume Reduction","Chronic Obstructive Pulmonary Disease","NOT_YET_RECRUITING","2025-07-30",{"date":79,"type":80},"2025-08-01","ACTUAL",{"date":82,"type":66},"2025-07",{"date":84,"type":66},"2027-07",{"name":5,"class":6},1]